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What is this view?

Binary interactions

In this tab, we display the list of interactions that you have selected using one of our search features. Despite the fact that our data are annotated to accurately reflect the interactions reported in scientific literature, the data is shown in this view as binary interactions. Whenever the data was reported as a co-complex involving more than two molecules, we store it as such in the IntAct database and post-process it so the portal can show it as binary interaction. This post-processing is the Spoke Expansion model (connects bait to all preys):



sourceExp

At any moment you can choose to display the expansion column in this view in order to see which interaction are spoke expanded and which are not.

Description of what has changed

  • We have added more download options to allow users to retrieve their interaction set using more standard formats such as PSI-MI XML and PSIMITAB (version 2.5, 2.6 or 2.7) but also XGMML, RDF and Biopax (level 2 and 3).
  • We have now four different table views : minimal(molecule names and interaction AC), basic (minimal + molecule links, interaction detection method, negative), standard(minimal + molecule species, confidences, publication details, experiment details), expanded (standard + more experiment details) and complete (all mitab 2.7 columns).

Configuring the view to your need"

In the header of the interaction table you will find a button: ‘Change Column Display’ that will show you all the columns/Table views available and allow you to update the current selected set.

Downloading the data into Standard formats"

In the header of the interaction table you will find a drop down list that contains all the formats currently supported when downloading the interaction data. Select one of them and click the export button next to the list. Please note that PSI-MI XML is only available when the interaction set is no bigger than 1000 interactions.

Opening the interaction details"

Clicking on the magnifying glass in the first column of the interaction table will open the details of the corresponding interaction in the Interaction Details tab, giving you access to more details of the manually curated record.

What is this view?

Browsing (Browse Tab)

This tab is meant to give you access to more content based on the currently selected set of interactions. Please note that linking to third party resources will only include up to 200 molecules , if you exceed this number you will see the warning icon (This number has been reduced to 125 molecules for mRNA expression). Now let’s look at the features available to you:

Limiting the scope of the current dataset with the Uniprot Taxonomy ontology

Allows users to browse the Uniprot Taxonomy hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the GO ontology

Allows users to browse the GO hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the ChEBI ontology

Allows users to browse the ChEBI hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Bulk linking to third party resources by using involved proteins

  • Proteins by Reactome pathway: Sends your proteins to the Reactome SkyPainter that will show you the pathways in which these molecules are know to play a role.
  • Proteins by Chromosomal location: Sends your list of proteins to Ensembl’s Karyotype viewer and overlays the proteins on the chromosomes.
  • Proteins by mRNA expression: Sends your set of proteins to the ArrayExpress Atlas that will show the known gene expression based on experimental studies.
What is this view?

Searching Interactions (Search Tab)

As you can see in this tab we are now trying to give you more targeted choice to do your queries, please note that the examples provided in this tab are live links so you can simply click them to see the resulting interactions sets.

Using the Quick Search

In this search panel you are free to type anything that might relate to interactions, whether it is properties of their interactor (gene name, identifiers, GO term…) or more specific to the interaction like publication, authors, experimental detection method, ...

Some examples:

  • Try the query: imatinib
    This is a drug for which we have curated a number of interactions.
    Once you press the search button you should be taken to the Interaction Tab that lists 130 binary interactions.
    If you want to construct more complex queries we recommend you take a look at the Molecular Interaction Query Language, accessible from the quick search panel.
  • Try the query: species:yeast AND type:"direct interaction"
    This query selects all interactions involving yeast interactors that have been shown to have direct interactions. If you customize the column display of the interaction tab, you will see that not only “direct interaction” have been selected but also children terms in the PSI-MI ontology.

Using the Ontology Search

Open the Rearch Tab. This panel is specialised to give you an easy access to ontology search. So far you can search on 4 ontologies:

  • Gene Ontology
  • InterPro
  • PSI-MI
  • ChEBI

Whenever you start typing a query in this search panel, the system will search as you type and propose a list of matching controlled vocabulary terms. You can then select one of them and select matching interactions.

For example, type: cancer
You will be presented with a few choices, please note that each term is followed by the count of matching interactions in the IntAct database.

Select a term with the mouse or using the keyboard cursor keys and you will be taken to the interaction tab.

Searching the Compound chemical structure

In this panel you will be able to draw all or part of a chemical structure and search for chemical compounds. If you get any matched, you can then see all interactions involving them.

First you have to open up the chemical search panel so that the applet can load, it might take a few seconds. Then you can start drawing your structure, for instance:

Once you have drawn your structure, select Similarity and press Search. You should be presented with a list of matching compound. Now choose one molecule and click the link: IntAct interactions. You will be taken to the interaction tab to review the data.

Complex Expansion

Binary interactions generated by co-complex expansion

Why should you care about complex expansion ?

Some experimental methods such as Tandem Affinity Purification do generate molecular interactions that can involve more than 2 molecules. Despite the fact that IntAct curation team do capture the molecular interaction as they were reported in the corresponding experiment, when you search using the intact web site, the results of your query is always shown as set of binary interactions (i.e. 2 molecules). We would like to draw your attention on the fact that whenever the reported interaction was a co-complex we do apply an expansion algorithm that transform this n-ary interaction into a set of binary interactions. While none of these agorithms is perfect and will very likely generate some false positive interactions, it is useful to present the data in a consistent manner. Bear in mind that we will strive to differentiate in the search results which interactions are a real experimental binary from expanded ones.

Existing expansion algorithm

There are several known algorithm allowing to transform an n-ary interaction into a set of binaries. The illustration below present the two well known expansion model and illustrates why they can be incorrect.



sourceExp

  • Spoke expansion: Links the bait molecule to all prey molecules. If N is the count of molecule in the complex, it generated N-1 binary interactions.
  • Matrix expansion: Links all molecule to all other molecule present in the complex. If N is the count of molecule in the complex, it generated (N*(N-1))/2 binary interactions.

Now the issue (as illustrated at the bottom right of the diagram above) with these two models lies in the fact that the real complex might not be articulated around the experimental bait but instead, this bait might be linked to a smaller complex, hence most binary interaction generated by spoke and matrix expansion result in false positive.



PSICQUIC

How is the number of interactions in other databases obtained?

PSICQUIC is a standard way to access molecular interaction databases across which it repeats the same query. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the PSICQUIC View, where you can browse the results in those other resources.

The services currently active are:

Check the PSICQUIC site for more information.

IMEx

What is the significance of the IMEx dataset?"

IMEx is a network of databases which have agreed to supply a non-redundant set of data expertly manually annotated to the same consistent detailed standard which, as such, represents a high-quality subset of the data each individually provides. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the IMEx View, where you can browse the results in those other resources.

The services currently active are:

Check the IMEx site for more information.

What is this view?

Representation of Experimental Features

This section shows the graphical representation of experimental features, where each participant is represented as a white rectangle with a black border and a line for each hundredth amino acid. All available features are attached to their associated participant and their categories are represented in the right side of the legend. The left side of the legend dynamically shows the range statuses occuring in the shown interaction. These are the possible range statuses:

sourceExp

Interacting with the widget

Hover over a feature to see more information in a tooltip.
sourceExp

To display a single interacting region click on it and click again to display all interacting regions.
Displaying all interacting regionsDisplaying one interacting region
sourceExpsourceExp
What is this view?

Dynamic molecular interaction data

This section shows the graphical representation of dynamic molecular interactions. By default it displays all the interactions from one experiment using radio buttons to allow users to highlight interactions in different variable conditions.

Publication

PubMed Id: 26496610

Journal: Cell

Year of Publication: 2015

Title: A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

Author List: Hein MY., Hubner NC., Poser I., Cox J., Nagaraj N., Toyoda Y., Gak IA., Weisswange I., Mansfeld J., Buchholz F., Hyman AA., Mann M.

Cross References:

Experiment (1323 interactions)

Accession: EBI-10990999

Name: hein-2015-2

Host organism: Homo sapiens epitheloid cervix carcinoma cells

Organism: Homo sapiens epitheloid cervix carcinoma cells

Accession: EBI-307614

Name: human-hela

Description: Homo sapiens epitheloid cervix carcinoma cells

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human
-

Interaction Detection Method: anti tag coip

Interaction detection method: anti tag coip
Accession: EBI-90

Name: anti tag coip

Description: anti tag coimmunoprecipitation

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0007
-
identity
pubmed
7708014
-
primary-reference


Annotations:
Topic
Text
definition
A specific antibody for the molecule of interest is not available, therefore the bait protein is expressed as a hybrid protein fused to a tag peptide/protein for which efficient and specific antibodies or a specific ligand are available.


Participant Identification Method: sequence tag

Participant identification method: sequence tag
Accession: EBI-81

Name: sequence tag

Description: sequence tag identification

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0102
-
identity
pubmed
10967324
-
primary-reference
pubmed
11752590
-
primary-reference
pubmed
11805837
-
primary-reference


Annotations:
Topic
Text
definition
This approach leads to protein identification by combining mass measurement and short amino acid sequence information obtained by tandem mass spectrometry. This information is then used to automatically find the best match in a sequence database. A mixture of peptides derived from a protease digestion is analysed by nanoelectrospray LC-MS/MS (Liquid Chromatography Tandem Mass Spectrometer or nanoESI MS/MS) mass spectrometry. Electrospray mass spectrometry cannot be applied to dilute samples and is affected by high salt. As a consequence peptides, normally extracted from acrylamide gels by in situ proteolysis, are desalted and concentrated on a microcolumn followed by elution into a capillary used for nanoelectrospray tandem mass spectrometry. A first mass spectrum (Normal mass spectrum or Q1 mass spectrum) gives information about the masses of all the peptides. Peptides observed in the normal mass spectrum are isolated in turn and dissociated into fragments by collision with gas molecules within the mass spectrometer. Some of the fragments obtained from a peptide constitute a nested set, differing by one amino acid, and the mass difference between them allows assignment of a partial sequence. The masses of the fragments define the position of the partial sequence in the peptide. Together with the cleavage specificity of the protease used to cleave the protein, and mass information such sequence tag provides much higher search specificity to match the a database entry. The procedure is repeated with several peptides from the digest, resulting in multiple identifications of the same protein or identification of several proteins from the peptide mixture. Unknown proteins can easily be identified by using the high specificity of the peptide sequence tag for searches in most sequence databases including EST or genome databases.


Cross References:

Annotations:

Topic
Text
Author confidence calculation Protein identifications as obtained from MS spectra processing were filtered, removing hits to the reverse decoy database as well as proteins only identified by modified peptides. It was required that each protein be quantified in all replicates from the AP-MS samples of at least one cell line. Protein LFQ intensities were logarithmized and missing values imputed by values simulating noise around the detection limit. For each protein, a non-parametric method was used to select a subset of samples that provide a distribution of background intensities for this protein. This subset was used first to normalize all protein intensities to represent relative enrichment, and then to serve as the control group for a two-tailed Welch’s t test. Specific outliers in the volcano plots of logarithmized p values against enrichments were determined by an approach making use of the asymmetry in the outlier population (see url links for each interaction). Two cut-offs of different stringencies, representing 1 and 5% of enrichment false discovery rate (FDR), respectively, were used. Correlation coefficients between the intensity profiles of interacting proteins were calculated as additional quality parameters. Enrichment FDR (classes A, B and C) and profile correlation (modifier + or –) define the confidence class of an interaction (see author assigned scores). Relative abundance and interaction stoichiometry estimations: Estimating interaction stoichiometries requires the comparison of the amounts of different proteins relative to each other in one IP. To this end, the authors first subtracted the median intensity across all samples to account for the proportion due to unspecific binding. Then LFQ intensities were divided by the number of theoretically observable peptides for this protein. This corrects for biases introduced by different lengths of the protein sequences and the frequency and distribution of proteolytic cleavage sites. Finally, interaction stoichiometries were expressed relative to the bait protein. Cellular copy numbers and relative abundances were calculated using a similar approach on the whole proteome data and brought to absolute scale by normalization to a total protein amount of 200 pg in a cell volume of 1 pl for a HeLa cell.
imex curation
hein@biochem.mpg.de,mmann@biochem.mpg.de
09-06-2015: Submitted by Marco Hein, Max Planck Institute of Biochemistry, Martinsried.
Only protein-protein interactions
-
PAM-SILAC experiments mentioned in the text and summarized in figure 5 were not added since the authors stated that the SILAC data just confirmed the large screening results for a set of selected baits and did not provide further detail on the interactions. The cell lines tested with PAM-SILAC were MCP_ky_0002211 (interaction id EBI-11003881), MCP_ky_0006158 (interaction id EBI-11131339) and MCP_ky_0003099 (interaction id EBI-11029579).

Interaction

Accession: EBI-11058729

Name: lima1-ablim1

Description: -

Type: association

Interaction type: association
Accession: EBI-1813191

Name: association

Description: association

Cross References:
Database
Identifier
Secondary identifier
Qualifier
pubmed
14755292
-
primary-reference
psi-mi
MI:0914
-
identity


Annotations:
Topic
Text
definition
Interaction between molecules that may participate in formation of one, but possibly more, physical complexes. Often describes a set of molecules that are co-purified in a single pull-down or coimmunoprecipitation but might participate in formation of distinct physical complexes sharing a common bait.


Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Suppl. table S2. For bait details see supp. table S1
Cell line id: MCP_ky_0003859

Participants (139)

Legend:
A
Annotation and Cross Reference  
P
Experimental Parameter   
S
Stoichiometry   
F
Experimental Feature
C
Participant Confidence
pp1234567pp
#
Name
Links
Primary Identifier
Aliases
Description
Species
Expression system
Experimental role
Biological role
Interactor type
More...
pp1234567pp
1
EBI-351479
 logo
PP624
LIMA1
SREBP3

[+2]
LIM domain and actin-binding protein 1
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
bait
Experimental role: bait
Accession: EBI-49

Name: bait

Description: bait

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0496
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally treated to capture its interacting partners.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference
so
SO:0000358
-
see-also


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: LIM domain and actin-binding protein 1

Participant: LIM domain and actin-binding protein 1

Accession: EBI-11058872

Name: EBI-351479

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

P
Participant: LIM domain and actin-binding protein 1

Participant: LIM domain and actin-binding protein 1

Accession: EBI-11058872

Name: EBI-351479

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: LIM domain and actin-binding protein 1

Participant: LIM domain and actin-binding protein 1

Accession: EBI-11058872

Name: EBI-351479

Stoichiometry: 0.0

F
Participant: LIM domain and actin-binding protein 1

Participant: LIM domain and actin-binding protein 1

Accession: EBI-11058872

Name: EBI-351479

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
lap tag
  • c-c
  • A
    Feature: EBI-11059435

    Feature: lap tag

    Accession: EBI-11059435

    Name: lap tag

    Annotations:

    Topic
    Text
    This tag was formed by the concatentation of the following sub-sequences: TEV cleavage site,S epitope,PreScission protease cleavage site,GFP


    C
    Participant: LIM domain and actin-binding protein 1

    Participant: LIM domain and actin-binding protein 1

    Accession: EBI-11058872

    Name: EBI-351479

    Confidences:

    Type
    Value
    No records found.

    2
    EBI-3893163
     logo
    AFAP1
    AFAP
    110 kDa actin filament-associated protein
    Actin filament-associated protein 1
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Actin filament-associated protein 1

    Participant: Actin filament-associated protein 1

    Accession: EBI-11058742

    Name: EBI-3893163

    Annotations:

    P
    Participant: Actin filament-associated protein 1

    Participant: Actin filament-associated protein 1

    Accession: EBI-11058742

    Name: EBI-3893163

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    7.024
    10
    -2
    0.0
    4.562
    10
    -1
    0.0


    S
    Participant: Actin filament-associated protein 1

    Participant: Actin filament-associated protein 1

    Accession: EBI-11058742

    Name: EBI-3893163

    Stoichiometry: 0.0

    F
    Participant: Actin filament-associated protein 1

    Participant: Actin filament-associated protein 1

    Accession: EBI-11058742

    Name: EBI-3893163

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Actin filament-associated protein 1

    Participant: Actin filament-associated protein 1

    Accession: EBI-11058742

    Name: EBI-3893163

    Confidences:

    Type
    Value
    A+

    3
    EBI-11025144
     logo
    INF2
    C14orf151
    C14orf173

    [+1]
    Inverted formin-2
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Inverted formin-2

    Participant: Inverted formin-2

    Accession: EBI-11058747

    Name: EBI-11025144

    Annotations:

    P
    Participant: Inverted formin-2

    Participant: Inverted formin-2

    Accession: EBI-11058747

    Name: EBI-11025144

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    1.321
    10
    -2
    0.0
    1.755
    10
    0
    0.0


    S
    Participant: Inverted formin-2

    Participant: Inverted formin-2

    Accession: EBI-11058747

    Name: EBI-11025144

    Stoichiometry: 0.0

    F
    Participant: Inverted formin-2

    Participant: Inverted formin-2

    Accession: EBI-11058747

    Name: EBI-11025144

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Inverted formin-2

    Participant: Inverted formin-2

    Accession: EBI-11058747

    Name: EBI-11025144

    Confidences:

    Type
    Value
    A+

    4
    EBI-397435
     logo logo logo logo
    CALM1
    CALM
    CAM

    [+9]
    Calmodulin
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Calmodulin

    Participant: Calmodulin

    Accession: EBI-11058752

    Name: EBI-397435

    Annotations:

    P
    Participant: Calmodulin

    Participant: Calmodulin

    Accession: EBI-11058752

    Name: EBI-397435

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    6.374
    10
    -1
    0.0
    1.44
    10
    2
    0.0


    S
    Participant: Calmodulin

    Participant: Calmodulin

    Accession: EBI-11058752

    Name: EBI-397435

    Stoichiometry: 0.0

    F
    Participant: Calmodulin

    Participant: Calmodulin

    Accession: EBI-11058752

    Name: EBI-397435

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Calmodulin

    Participant: Calmodulin

    Accession: EBI-11058752

    Name: EBI-397435

    Confidences:

    Type
    Value
    A+

    5
    EBI-1036803
     logo
    RAL
    RALA
    Ras-related protein Ral-A
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Ras-related protein Ral-A

    Participant: Ras-related protein Ral-A

    Accession: EBI-11058757

    Name: EBI-1036803

    Annotations:

    P
    Participant: Ras-related protein Ral-A

    Participant: Ras-related protein Ral-A

    Accession: EBI-11058757

    Name: EBI-1036803

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    1.374
    10
    -3
    0.0
    1.996
    10
    0
    0.0


    S
    Participant: Ras-related protein Ral-A

    Participant: Ras-related protein Ral-A

    Accession: EBI-11058757

    Name: EBI-1036803

    Stoichiometry: 0.0

    F
    Participant: Ras-related protein Ral-A

    Participant: Ras-related protein Ral-A

    Accession: EBI-11058757

    Name: EBI-1036803

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Ras-related protein Ral-A

    Participant: Ras-related protein Ral-A

    Accession: EBI-11058757

    Name: EBI-1036803

    Confidences:

    Type
    Value
    A

    6
    EBI-1048875
     logo
    Lactose-binding lectin 1
    14 kDa laminin-binding protein
    Lectin galactoside-binding soluble 1

    [+8]
    Galectin-1
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Galectin-1

    Participant: Galectin-1

    Accession: EBI-11058762

    Name: EBI-1048875

    Annotations:

    P
    Participant: Galectin-1

    Participant: Galectin-1

    Accession: EBI-11058762

    Name: EBI-1048875

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    1.445
    10
    -2
    0.0
    3.485
    10
    1
    0.0


    S
    Participant: Galectin-1

    Participant: Galectin-1

    Accession: EBI-11058762

    Name: EBI-1048875

    Stoichiometry: 0.0

    F
    Participant: Galectin-1

    Participant: Galectin-1

    Accession: EBI-11058762

    Name: EBI-1048875

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Galectin-1

    Participant: Galectin-1

    Accession: EBI-11058762

    Name: EBI-1048875

    Confidences:

    Type
    Value
    A+

    7
    EBI-945925
     logo
    Numb-related protein
    NUMBL
    Numb-like protein
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Numb-like protein

    Participant: Numb-like protein

    Accession: EBI-11058767

    Name: EBI-945925

    Annotations:

    P
    Participant: Numb-like protein

    Participant: Numb-like protein

    Accession: EBI-11058767

    Name: EBI-945925

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    9.888
    10
    -5
    0.0
    6.107
    10
    -2
    0.0


    S
    Participant: Numb-like protein

    Participant: Numb-like protein

    Accession: EBI-11058767

    Name: EBI-945925

    Stoichiometry: 0.0

    F
    Participant: Numb-like protein

    Participant: Numb-like protein

    Accession: EBI-11058767

    Name: EBI-945925

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Numb-like protein

    Participant: Numb-like protein

    Accession: EBI-11058767

    Name: EBI-945925

    Confidences:

    Type
    Value
    A

    8
    EBI-10965256
     logo
    AP2M1
    AP-2 mu chain
    Adaptin-mu2

    [+9]
    AP-2 complex subunit mu
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: AP-2 complex subunit mu

    Participant: AP-2 complex subunit mu

    Accession: EBI-11058772

    Name: EBI-10965256

    Annotations:

    P
    Participant: AP-2 complex subunit mu

    Participant: AP-2 complex subunit mu

    Accession: EBI-11058772

    Name: EBI-10965256

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    2.724
    10
    -2
    0.0
    1.775
    10
    0
    0.0


    S
    Participant: AP-2 complex subunit mu

    Participant: AP-2 complex subunit mu

    Accession: EBI-11058772

    Name: EBI-10965256

    Stoichiometry: 0.0

    F
    Participant: AP-2 complex subunit mu

    Participant: AP-2 complex subunit mu

    Accession: EBI-11058772

    Name: EBI-10965256

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: AP-2 complex subunit mu

    Participant: AP-2 complex subunit mu

    Accession: EBI-11058772

    Name: EBI-10965256

    Confidences:

    Type
    Value
    A+

    9
    EBI-311323
     logo
    Arg-binding protein 2
    SORBS2
    ARGBP2

    [+3]
    Sorbin and SH3 domain-containing protein 2
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Sorbin and SH3 domain-containing protein 2

    Participant: Sorbin and SH3 domain-containing protein 2

    Accession: EBI-11058777

    Name: EBI-311323

    Annotations:

    P
    Participant: Sorbin and SH3 domain-containing protein 2

    Participant: Sorbin and SH3 domain-containing protein 2

    Accession: EBI-11058777

    Name: EBI-311323

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    1.4
    10
    -4
    0.0
    2.055
    10
    -2
    0.0


    S
    Participant: Sorbin and SH3 domain-containing protein 2

    Participant: Sorbin and SH3 domain-containing protein 2

    Accession: EBI-11058777

    Name: EBI-311323

    Stoichiometry: 0.0

    F
    Participant: Sorbin and SH3 domain-containing protein 2

    Participant: Sorbin and SH3 domain-containing protein 2

    Accession: EBI-11058777

    Name: EBI-311323

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Sorbin and SH3 domain-containing protein 2

    Participant: Sorbin and SH3 domain-containing protein 2

    Accession: EBI-11058777

    Name: EBI-311323

    Confidences:

    Type
    Value
    A

    10
    EBI-350467
     logo
    LUZP1
    Leucine zipper protein 1
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Leucine zipper protein 1

    Participant: Leucine zipper protein 1

    Accession: EBI-11058782

    Name: EBI-350467

    Annotations:

    P
    Participant: Leucine zipper protein 1

    Participant: Leucine zipper protein 1

    Accession: EBI-11058782

    Name: EBI-350467

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    3.094
    10
    -4
    0.0
    6.023
    10
    -1
    0.0


    S
    Participant: Leucine zipper protein 1

    Participant: Leucine zipper protein 1

    Accession: EBI-11058782

    Name: EBI-350467

    Stoichiometry: 0.0

    F
    Participant: Leucine zipper protein 1

    Participant: Leucine zipper protein 1

    Accession: EBI-11058782

    Name: EBI-350467

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Leucine zipper protein 1

    Participant: Leucine zipper protein 1

    Accession: EBI-11058782

    Name: EBI-350467

    Confidences:

    Type
    Value
    C+

    11
    EBI-711189
     logo
    Arp2/3 complex 16 kDa subunit 2
    ARPC5L
    Actin-related protein 2/3 complex subunit 5-like protein
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Actin-related protein 2/3 complex subunit 5-like protein

    Participant: Actin-related protein 2/3 complex subunit 5-like protein

    Accession: EBI-11058787

    Name: EBI-711189

    Annotations:

    P
    Participant: Actin-related protein 2/3 complex subunit 5-like protein

    Participant: Actin-related protein 2/3 complex subunit 5-like protein

    Accession: EBI-11058787

    Name: EBI-711189

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    5.341
    10
    -4
    0.0
    1.019
    10
    1
    0.0


    S
    Participant: Actin-related protein 2/3 complex subunit 5-like protein

    Participant: Actin-related protein 2/3 complex subunit 5-like protein

    Accession: EBI-11058787

    Name: EBI-711189

    Stoichiometry: 0.0

    F
    Participant: Actin-related protein 2/3 complex subunit 5-like protein

    Participant: Actin-related protein 2/3 complex subunit 5-like protein

    Accession: EBI-11058787

    Name: EBI-711189

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Actin-related protein 2/3 complex subunit 5-like protein

    Participant: Actin-related protein 2/3 complex subunit 5-like protein

    Accession: EBI-11058787

    Name: EBI-711189

    Confidences:

    Type
    Value
    C

    12
    EBI-4290759
     logo
    EFHD2
    SWS1
    Swiprosin-1
    EF-hand domain-containing protein D2
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: EF-hand domain-containing protein D2

    Participant: EF-hand domain-containing protein D2

    Accession: EBI-11058792

    Name: EBI-4290759

    Annotations:

    P
    Participant: EF-hand domain-containing protein D2

    Participant: EF-hand domain-containing protein D2

    Accession: EBI-11058792

    Name: EBI-4290759

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    2.272
    10
    -4
    0.0
    1.83
    10
    1
    0.0


    S
    Participant: EF-hand domain-containing protein D2

    Participant: EF-hand domain-containing protein D2

    Accession: EBI-11058792

    Name: EBI-4290759

    Stoichiometry: 0.0

    F
    Participant: EF-hand domain-containing protein D2

    Participant: EF-hand domain-containing protein D2

    Accession: EBI-11058792

    Name: EBI-4290759

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: EF-hand domain-containing protein D2

    Participant: EF-hand domain-containing protein D2

    Accession: EBI-11058792

    Name: EBI-4290759

    Confidences:

    Type
    Value
    B

    13
    EBI-355586
     logo
    CAPZA1
    CapZ alpha-1
    F-actin-capping protein subunit alpha-1
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: F-actin-capping protein subunit alpha-1

    Participant: F-actin-capping protein subunit alpha-1

    Accession: EBI-11058797

    Name: EBI-355586

    Annotations:

    P
    Participant: F-actin-capping protein subunit alpha-1

    Participant: F-actin-capping protein subunit alpha-1

    Accession: EBI-11058797

    Name: EBI-355586

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    3.787
    10
    -2
    0.0
    2.345
    10
    1
    0.0


    S
    Participant: F-actin-capping protein subunit alpha-1

    Participant: F-actin-capping protein subunit alpha-1

    Accession: EBI-11058797

    Name: EBI-355586

    Stoichiometry: 0.0

    F
    Participant: F-actin-capping protein subunit alpha-1

    Participant: F-actin-capping protein subunit alpha-1

    Accession: EBI-11058797

    Name: EBI-355586

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: F-actin-capping protein subunit alpha-1

    Participant: F-actin-capping protein subunit alpha-1

    Accession: EBI-11058797

    Name: EBI-355586

    Confidences:

    Type
    Value
    B+

    14
    EBI-624860
     logo
    SH3 domain-binding protein that preferentially associates with BTK
    SH3BP5
    SAB
    SH3 domain-binding protein 5
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: SH3 domain-binding protein 5

    Participant: SH3 domain-binding protein 5

    Accession: EBI-11058802

    Name: EBI-624860

    Annotations:

    P
    Participant: SH3 domain-binding protein 5

    Participant: SH3 domain-binding protein 5

    Accession: EBI-11058802

    Name: EBI-624860

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    1.062
    10
    -4
    0.0
    7.314
    10
    -2
    0.0


    S
    Participant: SH3 domain-binding protein 5

    Participant: SH3 domain-binding protein 5

    Accession: EBI-11058802

    Name: EBI-624860

    Stoichiometry: 0.0

    F
    Participant: SH3 domain-binding protein 5

    Participant: SH3 domain-binding protein 5

    Accession: EBI-11058802

    Name: EBI-624860

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: SH3 domain-binding protein 5

    Participant: SH3 domain-binding protein 5

    Accession: EBI-11058802

    Name: EBI-624860

    Confidences:

    Type
    Value
    B

    15
    EBI-352614
     logo
    TMOD3
    Ubiquitous tropomodulin
    Tropomodulin-3
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Tropomodulin-3

    Participant: Tropomodulin-3

    Accession: EBI-11058807

    Name: EBI-352614

    Annotations:

    P
    Participant: Tropomodulin-3

    Participant: Tropomodulin-3

    Accession: EBI-11058807

    Name: EBI-352614

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    1.299
    10
    -1
    0.0
    9.633
    10
    0
    0.0


    S
    Participant: Tropomodulin-3

    Participant: Tropomodulin-3

    Accession: EBI-11058807

    Name: EBI-352614

    Stoichiometry: 0.0

    F
    Participant: Tropomodulin-3

    Participant: Tropomodulin-3

    Accession: EBI-11058807

    Name: EBI-352614

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Tropomodulin-3

    Participant: Tropomodulin-3

    Accession: EBI-11058807

    Name: EBI-352614

    Confidences:

    Type
    Value
    A+

    16
    EBI-351394
     logo
    DBN1
    Developmentally-regulated brain protein
    D0S117E
    Drebrin
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Drebrin

    Participant: Drebrin

    Accession: EBI-11058812

    Name: EBI-351394

    Annotations:

    P
    Participant: Drebrin

    Participant: Drebrin

    Accession: EBI-11058812

    Name: EBI-351394

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    3.583
    10
    -1
    0.0
    1.426
    10
    0
    0.0


    S
    Participant: Drebrin

    Participant: Drebrin

    Accession: EBI-11058812

    Name: EBI-351394

    Stoichiometry: 0.0

    F
    Participant: Drebrin

    Participant: Drebrin

    Accession: EBI-11058812

    Name: EBI-351394

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Drebrin

    Participant: Drebrin

    Accession: EBI-11058812

    Name: EBI-351394

    Confidences:

    Type
    Value
    B+

    17
    EBI-367427
     logo
    K-Ras4B
    KRAS
    KRAS2

    [+5]
    GTPase KRas
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: GTPase KRas

    Participant: GTPase KRas

    Accession: EBI-11058817

    Name: EBI-367427

    Annotations:

    P
    Participant: GTPase KRas

    Participant: GTPase KRas

    Accession: EBI-11058817

    Name: EBI-367427

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    1.41
    10
    -3
    0.0
    1.976
    10
    0
    0.0


    S
    Participant: GTPase KRas

    Participant: GTPase KRas

    Accession: EBI-11058817

    Name: EBI-367427

    Stoichiometry: 0.0

    F
    Participant: GTPase KRas

    Participant: GTPase KRas

    Accession: EBI-11058817

    Name: EBI-367427

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: GTPase KRas

    Participant: GTPase KRas

    Accession: EBI-11058817

    Name: EBI-367427

    Confidences:

    Type
    Value
    B-

    18
    EBI-2856617
     logo
    RAP2C
    Ras-related protein Rap-2c
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Ras-related protein Rap-2c

    Participant: Ras-related protein Rap-2c

    Accession: EBI-11058822

    Name: EBI-2856617

    Annotations:

    P
    Participant: Ras-related protein Rap-2c

    Participant: Ras-related protein Rap-2c

    Accession: EBI-11058822

    Name: EBI-2856617

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    3.518
    10
    -5
    0.0
    1.613
    10
    0
    0.0


    S
    Participant: Ras-related protein Rap-2c

    Participant: Ras-related protein Rap-2c

    Accession: EBI-11058822

    Name: EBI-2856617

    Stoichiometry: 0.0

    F
    Participant: Ras-related protein Rap-2c

    Participant: Ras-related protein Rap-2c

    Accession: EBI-11058822

    Name: EBI-2856617

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Ras-related protein Rap-2c

    Participant: Ras-related protein Rap-2c

    Accession: EBI-11058822

    Name: EBI-2856617

    Confidences:

    Type
    Value
    B

    19
    EBI-1044647
     logo
    Arp2/3 complex 41 kDa subunit
    p41-ARC
    ARPC1B

    [+1]
    Actin-related protein 2/3 complex subunit 1B
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Actin-related protein 2/3 complex subunit 1B

    Participant: Actin-related protein 2/3 complex subunit 1B

    Accession: EBI-11058827

    Name: EBI-1044647

    Annotations:

    P
    Participant: Actin-related protein 2/3 complex subunit 1B

    Participant: Actin-related protein 2/3 complex subunit 1B

    Accession: EBI-11058827

    Name: EBI-1044647

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    5.936
    10
    -4
    0.0
    4.559
    10
    0
    0.0


    S
    Participant: Actin-related protein 2/3 complex subunit 1B

    Participant: Actin-related protein 2/3 complex subunit 1B

    Accession: EBI-11058827

    Name: EBI-1044647

    Stoichiometry: 0.0

    F
    Participant: Actin-related protein 2/3 complex subunit 1B

    Participant: Actin-related protein 2/3 complex subunit 1B

    Accession: EBI-11058827

    Name: EBI-1044647

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Actin-related protein 2/3 complex subunit 1B

    Participant: Actin-related protein 2/3 complex subunit 1B

    Accession: EBI-11058827

    Name: EBI-1044647

    Confidences:

    Type
    Value
    B+

    20
    EBI-10977819
     logo
    NEXN
    F-actin-binding protein
    Nelin
    Nexilin
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference
    so
    SO:0000358
    -
    see-also


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Nexilin

    Participant: Nexilin

    Accession: EBI-11058832

    Name: EBI-10977819

    Annotations:

    P
    Participant: Nexilin

    Participant: Nexilin

    Accession: EBI-11058832

    Name: EBI-10977819

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    3.752
    10
    -2
    0.0
    1.22
    10
    -2
    0.0


    S
    Participant: Nexilin

    Participant: Nexilin

    Accession: EBI-11058832

    Name: EBI-10977819

    Stoichiometry: 0.0

    F
    Participant: Nexilin

    Participant: Nexilin

    Accession: EBI-11058832

    Name: EBI-10977819

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Nexilin

    Participant: Nexilin

    Accession: EBI-11058832

    Name: EBI-10977819

    Confidences:

    Type
    Value
    A+


    Graphical Representation of Experimental Features