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What is this view?

Binary interactions

In this tab, we display the list of interactions that you have selected using one of our search features. Despite the fact that our data are annotated to accurately reflect the interactions reported in scientific literature, the data is shown in this view as binary interactions. Whenever the data was reported as a co-complex involving more than two molecules, we store it as such in the IntAct database and post-process it so the portal can show it as binary interaction. This post-processing is the Spoke Expansion model (connects bait to all preys):



sourceExp

At any moment you can choose to display the expansion column in this view in order to see which interaction are spoke expanded and which are not.

Description of what has changed

  • We have added more download options to allow users to retrieve their interaction set using more standard formats such as PSI-MI XML and PSIMITAB (version 2.5, 2.6 or 2.7) but also XGMML, RDF and Biopax (level 2 and 3).
  • We have now four different table views : minimal(molecule names and interaction AC), basic (minimal + molecule links, interaction detection method, negative), standard(minimal + molecule species, confidences, publication details, experiment details), expanded (standard + more experiment details) and complete (all mitab 2.7 columns).

Configuring the view to your need"

In the header of the interaction table you will find a button: ‘Change Column Display’ that will show you all the columns/Table views available and allow you to update the current selected set.

Downloading the data into Standard formats"

In the header of the interaction table you will find a drop down list that contains all the formats currently supported when downloading the interaction data. Select one of them and click the export button next to the list. Please note that PSI-MI XML is only available when the interaction set is no bigger than 1000 interactions.

Opening the interaction details"

Clicking on the magnifying glass in the first column of the interaction table will open the details of the corresponding interaction in the Interaction Details tab, giving you access to more details of the manually curated record.

What is this view?

Browsing (Browse Tab)

This tab is meant to give you access to more content based on the currently selected set of interactions. Please note that linking to third party resources will only include up to 200 molecules , if you exceed this number you will see the warning icon (This number has been reduced to 125 molecules for mRNA expression). Now let’s look at the features available to you:

Limiting the scope of the current dataset with the Uniprot Taxonomy ontology

Allows users to browse the Uniprot Taxonomy hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the GO ontology

Allows users to browse the GO hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Limiting the scope of the current dataset with the ChEBI ontology

Allows users to browse the ChEBI hierarchy as a tree and select terms in order to narrow down their dataset. Once a term is selected, you are taken back to the interaction tab to review your dataset.

Bulk linking to third party resources by using involved proteins

  • Proteins by Reactome pathway: Sends your proteins to the Reactome SkyPainter that will show you the pathways in which these molecules are know to play a role.
  • Proteins by Chromosomal location: Sends your list of proteins to Ensembl’s Karyotype viewer and overlays the proteins on the chromosomes.
  • Proteins by mRNA expression: Sends your set of proteins to the ArrayExpress Atlas that will show the known gene expression based on experimental studies.
What is this view?

Searching Interactions (Search Tab)

As you can see in this tab we are now trying to give you more targeted choice to do your queries, please note that the examples provided in this tab are live links so you can simply click them to see the resulting interactions sets.

Using the Quick Search

In this search panel you are free to type anything that might relate to interactions, whether it is properties of their interactor (gene name, identifiers, GO term…) or more specific to the interaction like publication, authors, experimental detection method, ...

Some examples:

  • Try the query: imatinib
    This is a drug for which we have curated a number of interactions.
    Once you press the search button you should be taken to the Interaction Tab that lists 130 binary interactions.
    If you want to construct more complex queries we recommend you take a look at the Molecular Interaction Query Language, accessible from the quick search panel.
  • Try the query: species:yeast AND type:"direct interaction"
    This query selects all interactions involving yeast interactors that have been shown to have direct interactions. If you customize the column display of the interaction tab, you will see that not only “direct interaction” have been selected but also children terms in the PSI-MI ontology.

Using the Ontology Search

Open the Rearch Tab. This panel is specialised to give you an easy access to ontology search. So far you can search on 4 ontologies:

  • Gene Ontology
  • InterPro
  • PSI-MI
  • ChEBI

Whenever you start typing a query in this search panel, the system will search as you type and propose a list of matching controlled vocabulary terms. You can then select one of them and select matching interactions.

For example, type: cancer
You will be presented with a few choices, please note that each term is followed by the count of matching interactions in the IntAct database.

Select a term with the mouse or using the keyboard cursor keys and you will be taken to the interaction tab.

Searching the Compound chemical structure

In this panel you will be able to draw all or part of a chemical structure and search for chemical compounds. If you get any matched, you can then see all interactions involving them.

First you have to open up the chemical search panel so that the applet can load, it might take a few seconds. Then you can start drawing your structure, for instance:

Once you have drawn your structure, select Similarity and press Search. You should be presented with a list of matching compound. Now choose one molecule and click the link: IntAct interactions. You will be taken to the interaction tab to review the data.

Complex Expansion

Binary interactions generated by co-complex expansion

Why should you care about complex expansion ?

Some experimental methods such as Tandem Affinity Purification do generate molecular interactions that can involve more than 2 molecules. Despite the fact that IntAct curation team do capture the molecular interaction as they were reported in the corresponding experiment, when you search using the intact web site, the results of your query is always shown as set of binary interactions (i.e. 2 molecules). We would like to draw your attention on the fact that whenever the reported interaction was a co-complex we do apply an expansion algorithm that transform this n-ary interaction into a set of binary interactions. While none of these agorithms is perfect and will very likely generate some false positive interactions, it is useful to present the data in a consistent manner. Bear in mind that we will strive to differentiate in the search results which interactions are a real experimental binary from expanded ones.

Existing expansion algorithm

There are several known algorithm allowing to transform an n-ary interaction into a set of binaries. The illustration below present the two well known expansion model and illustrates why they can be incorrect.



sourceExp

  • Spoke expansion: Links the bait molecule to all prey molecules. If N is the count of molecule in the complex, it generated N-1 binary interactions.
  • Matrix expansion: Links all molecule to all other molecule present in the complex. If N is the count of molecule in the complex, it generated (N*(N-1))/2 binary interactions.

Now the issue (as illustrated at the bottom right of the diagram above) with these two models lies in the fact that the real complex might not be articulated around the experimental bait but instead, this bait might be linked to a smaller complex, hence most binary interaction generated by spoke and matrix expansion result in false positive.



PSICQUIC

How is the number of interactions in other databases obtained?

PSICQUIC is a standard way to access molecular interaction databases across which it repeats the same query. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the PSICQUIC View, where you can browse the results in those other resources.

The services currently active are:

Check the PSICQUIC site for more information.

IMEx

What is the significance of the IMEx dataset?"

IMEx is a network of databases which have agreed to supply a non-redundant set of data expertly manually annotated to the same consistent detailed standard which, as such, represents a high-quality subset of the data each individually provides. The number of databases providing data may vary, depending on the status of their services and only those that are active are used in this query. By clicking on the number of interactions you will be redirected to the IMEx View, where you can browse the results in those other resources.

The services currently active are:

Check the IMEx site for more information.

What is this view?

Representation of Experimental Features

This section shows the graphical representation of experimental features, where each participant is represented as a white rectangle with a black border and a line for each hundredth amino acid. All available features are attached to their associated participant and their categories are represented in the right side of the legend. The left side of the legend dynamically shows the range statuses occuring in the shown interaction. These are the possible range statuses:

sourceExp

Interacting with the widget

Hover over a feature to see more information in a tooltip.
sourceExp

To display a single interacting region click on it and click again to display all interacting regions.
Displaying all interacting regionsDisplaying one interacting region
sourceExpsourceExp
What is this view?

Dynamic molecular interaction data

This section shows the graphical representation of dynamic molecular interactions. By default it displays all the interactions from one experiment using radio buttons to allow users to highlight interactions in different variable conditions.

Publication

PubMed Id: 26496610

Journal: Cell

Year of Publication: 2015

Title: A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

Author List: Hein MY., Hubner NC., Poser I., Cox J., Nagaraj N., Toyoda Y., Gak IA., Weisswange I., Mansfeld J., Buchholz F., Hyman AA., Mann M.

Cross References:

Experiment (1323 interactions)

Accession: EBI-10990999

Name: hein-2015-2

Host organism: Homo sapiens epitheloid cervix carcinoma cells

Organism: Homo sapiens epitheloid cervix carcinoma cells

Accession: EBI-307614

Name: human-hela

Description: Homo sapiens epitheloid cervix carcinoma cells

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human
-

Interaction Detection Method: anti tag coip

Interaction detection method: anti tag coip
Accession: EBI-90

Name: anti tag coip

Description: anti tag coimmunoprecipitation

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0007
-
identity
pubmed
7708014
-
primary-reference


Annotations:
Topic
Text
definition
A specific antibody for the molecule of interest is not available, therefore the bait protein is expressed as a hybrid protein fused to a tag peptide/protein for which efficient and specific antibodies or a specific ligand are available.


Participant Identification Method: sequence tag

Participant identification method: sequence tag
Accession: EBI-81

Name: sequence tag

Description: sequence tag identification

Cross References:
Database
Identifier
Secondary identifier
Qualifier
pubmed
11805837
-
see-also
psi-mi
MI:0102
-
identity
pubmed
10967324
-
primary-reference
pubmed
11752590
-
primary-reference


Annotations:
Topic
Text
definition
This approach leads to protein identification by combining mass measurement and short amino acid sequence information obtained by tandem mass spectrometry. This information is then used to automatically find the best match in a sequence database. A mixture of peptides derived from a protease digestion is analysed by nanoelectrospray LC-MS/MS (Liquid Chromatography Tandem Mass Spectrometer or nanoESI MS/MS) mass spectrometry. Electrospray mass spectrometry cannot be applied to dilute samples and is affected by high salt. As a consequence peptides, normally extracted from acrylamide gels by in situ proteolysis, are desalted and concentrated on a microcolumn followed by elution into a capillary used for nanoelectrospray tandem mass spectrometry. A first mass spectrum (Normal mass spectrum or Q1 mass spectrum) gives information about the masses of all the peptides. Peptides observed in the normal mass spectrum are isolated in turn and dissociated into fragments by collision with gas molecules within the mass spectrometer. Some of the fragments obtained from a peptide constitute a nested set, differing by one amino acid, and the mass difference between them allows assignment of a partial sequence. The masses of the fragments define the position of the partial sequence in the peptide. Together with the cleavage specificity of the protease used to cleave the protein, and mass information such sequence tag provides much higher search specificity to match the a database entry. The procedure is repeated with several peptides from the digest, resulting in multiple identifications of the same protein or identification of several proteins from the peptide mixture. Unknown proteins can easily be identified by using the high specificity of the peptide sequence tag for searches in most sequence databases including EST or genome databases.


Cross References:

Annotations:

Topic
Text
Author confidence calculation Protein identifications as obtained from MS spectra processing were filtered, removing hits to the reverse decoy database as well as proteins only identified by modified peptides. It was required that each protein be quantified in all replicates from the AP-MS samples of at least one cell line. Protein LFQ intensities were logarithmized and missing values imputed by values simulating noise around the detection limit. For each protein, a non-parametric method was used to select a subset of samples that provide a distribution of background intensities for this protein. This subset was used first to normalize all protein intensities to represent relative enrichment, and then to serve as the control group for a two-tailed Welch’s t test. Specific outliers in the volcano plots of logarithmized p values against enrichments were determined by an approach making use of the asymmetry in the outlier population (see url links for each interaction). Two cut-offs of different stringencies, representing 1 and 5% of enrichment false discovery rate (FDR), respectively, were used. Correlation coefficients between the intensity profiles of interacting proteins were calculated as additional quality parameters. Enrichment FDR (classes A, B and C) and profile correlation (modifier + or –) define the confidence class of an interaction (see author assigned scores). Relative abundance and interaction stoichiometry estimations: Estimating interaction stoichiometries requires the comparison of the amounts of different proteins relative to each other in one IP. To this end, the authors first subtracted the median intensity across all samples to account for the proportion due to unspecific binding. Then LFQ intensities were divided by the number of theoretically observable peptides for this protein. This corrects for biases introduced by different lengths of the protein sequences and the frequency and distribution of proteolytic cleavage sites. Finally, interaction stoichiometries were expressed relative to the bait protein. Cellular copy numbers and relative abundances were calculated using a similar approach on the whole proteome data and brought to absolute scale by normalization to a total protein amount of 200 pg in a cell volume of 1 pl for a HeLa cell.
imex curation
hein@biochem.mpg.de,mmann@biochem.mpg.de
09-06-2015: Submitted by Marco Hein, Max Planck Institute of Biochemistry, Martinsried.
Only protein-protein interactions
-
PAM-SILAC experiments mentioned in the text and summarized in figure 5 were not added since the authors stated that the SILAC data just confirmed the large screening results for a set of selected baits and did not provide further detail on the interactions. The cell lines tested with PAM-SILAC were MCP_ky_0002211 (interaction id EBI-11003881), MCP_ky_0006158 (interaction id EBI-11131339) and MCP_ky_0003099 (interaction id EBI-11029579).

Interaction

Accession: EBI-11011991

Name: ywhaz-ap3b1-1

Description: -

Type: association

Interaction type: association
Accession: EBI-1813191

Name: association

Description: association

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0914
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Interaction between molecules that may participate in formation of one, but possibly more, physical complexes. Often describes a set of molecules that are co-purified in a single pull-down or coimmunoprecipitation but might participate in formation of distinct physical complexes sharing a common bait.


Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

Annotations:

Topic
Text
Suppl. table S2. For bait details see supp. table S1
Cell line id: MCP_ky_0002448

Participants (16)

Legend:
A
Annotation and Cross Reference  
P
Experimental Parameter   
S
Stoichiometry   
F
Experimental Feature
C
Participant Confidence
#
Name
Links
Primary Identifier
Aliases
Description
Species
Expression system
Experimental role
Biological role
Interactor type
More...
1
EBI-347088
 logo
YWHAZ
Protein kinase C inhibitor protein 1
14-3-3 protein zeta/delta
Homo sapiens
Organism Details

Accession: EBI-874

Name: human

Description: Homo sapiens

Cross References:

Database
Identifier
Secondary identifier
Qualifier
human

Expressed In Details

Accession:

Name:

-
bait
Experimental role: bait
Accession: EBI-49

Name: bait

Description: bait

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0496
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Molecule experimentally treated to capture its interacting partners.


unspecified role
Biological role: unspecified role
Accession: EBI-77781

Name: unspecified role

Description: unspecified role

Cross References:
Database
Identifier
Secondary identifier
Qualifier
psi-mi
MI:0499
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
Role not specified or not applicable to the data.


protein
Interactor type: protein
Accession: EBI-619654

Name: protein

Description: protein

Cross References:
Database
Identifier
Secondary identifier
Qualifier
so
SO:0000358
-
see-also
psi-mi
MI:0326
-
identity
pubmed
14755292
-
primary-reference


Annotations:
Topic
Text
definition
A linear polymer of amino acids joined by peptide bonds in a specific sequence.


A
Participant: 14-3-3 protein zeta/delta

Participant: 14-3-3 protein zeta/delta

Accession: EBI-11012010

Name: EBI-347088

Cross References:

Database
Identifier
Secondary identifier
Qualifier
-

P
Participant: 14-3-3 protein zeta/delta

Participant: 14-3-3 protein zeta/delta

Accession: EBI-11012010

Name: EBI-347088

Parameters:

Type
Value
Unit
Base
Exponent
Uncertainty
No records found.


S
Participant: 14-3-3 protein zeta/delta

Participant: 14-3-3 protein zeta/delta

Accession: EBI-11012010

Name: EBI-347088

Stoichiometry: 0.0

F
Participant: 14-3-3 protein zeta/delta

Participant: 14-3-3 protein zeta/delta

Accession: EBI-11012010

Name: EBI-347088

Features:

Legend:
A
Annotation and Cross Reference  
Feature Name
Feature Type
Detection Method
Range positions
More...
lap tag
  • c-c
  • A
    Feature: EBI-11012073

    Feature: lap tag

    Accession: EBI-11012073

    Name: lap tag

    Annotations:

    Topic
    Text
    This tag was formed by the concatentation of the following sub-sequences: TEV cleavage site,S epitope,PreScission protease cleavage site,GFP


    C
    Participant: 14-3-3 protein zeta/delta

    Participant: 14-3-3 protein zeta/delta

    Accession: EBI-11012010

    Name: EBI-347088

    Confidences:

    Type
    Value
    No records found.

    2
    EBI-2850901
     logo
    UHRF1BP1L
    Syntaxin-6 Habc-interacting protein of 164 kDa
    SHIP164

    [+1]
    UHRF1-binding protein 1-like
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: UHRF1-binding protein 1-like

    Participant: UHRF1-binding protein 1-like

    Accession: EBI-11011995

    Name: EBI-2850901

    Annotations:

    P
    Participant: UHRF1-binding protein 1-like

    Participant: UHRF1-binding protein 1-like

    Accession: EBI-11011995

    Name: EBI-2850901

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    6.631
    10
    -3
    0.0
    2.824
    10
    -4
    0.0


    S
    Participant: UHRF1-binding protein 1-like

    Participant: UHRF1-binding protein 1-like

    Accession: EBI-11011995

    Name: EBI-2850901

    Stoichiometry: 0.0

    F
    Participant: UHRF1-binding protein 1-like

    Participant: UHRF1-binding protein 1-like

    Accession: EBI-11011995

    Name: EBI-2850901

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: UHRF1-binding protein 1-like

    Participant: UHRF1-binding protein 1-like

    Accession: EBI-11011995

    Name: EBI-2850901

    Confidences:

    Type
    Value
    A

    3
    EBI-359063
     logo
    COPB1
    Beta-coat protein
    COPB

    [+1]
    Coatomer subunit beta
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Coatomer subunit beta

    Participant: Coatomer subunit beta

    Accession: EBI-11012000

    Name: EBI-359063

    Annotations:

    P
    Participant: Coatomer subunit beta

    Participant: Coatomer subunit beta

    Accession: EBI-11012000

    Name: EBI-359063

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    1.72
    10
    -1
    0.0
    4.386
    10
    -2
    0.0


    S
    Participant: Coatomer subunit beta

    Participant: Coatomer subunit beta

    Accession: EBI-11012000

    Name: EBI-359063

    Stoichiometry: 0.0

    F
    Participant: Coatomer subunit beta

    Participant: Coatomer subunit beta

    Accession: EBI-11012000

    Name: EBI-359063

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Coatomer subunit beta

    Participant: Coatomer subunit beta

    Accession: EBI-11012000

    Name: EBI-359063

    Confidences:

    Type
    Value
    B-

    4
    EBI-358919
     logo
    SEC61A1
    SEC61A
    Protein transport protein Sec61 subunit alpha isoform 1
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Protein transport protein Sec61 subunit alpha isoform 1

    Participant: Protein transport protein Sec61 subunit alpha isoform 1

    Accession: EBI-11012005

    Name: EBI-358919

    Annotations:

    Topic
    Text
    Low enrichment precludes background subtraction required for interaction stoichiometry calculation.
    Missing cellular copy number precludes calculation of relative abundance.
    B

    P
    Participant: Protein transport protein Sec61 subunit alpha isoform 1

    Participant: Protein transport protein Sec61 subunit alpha isoform 1

    Accession: EBI-11012005

    Name: EBI-358919

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: Protein transport protein Sec61 subunit alpha isoform 1

    Participant: Protein transport protein Sec61 subunit alpha isoform 1

    Accession: EBI-11012005

    Name: EBI-358919

    Stoichiometry: 0.0

    F
    Participant: Protein transport protein Sec61 subunit alpha isoform 1

    Participant: Protein transport protein Sec61 subunit alpha isoform 1

    Accession: EBI-11012005

    Name: EBI-358919

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Protein transport protein Sec61 subunit alpha isoform 1

    Participant: Protein transport protein Sec61 subunit alpha isoform 1

    Accession: EBI-11012005

    Name: EBI-358919

    Confidences:

    Type
    Value
    B

    5
    EBI-356498
     logo
    YWHAE
    14-3-3 protein epsilon
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: 14-3-3 protein epsilon

    Participant: 14-3-3 protein epsilon

    Accession: EBI-11012013

    Name: EBI-356498

    Annotations:

    P
    Participant: 14-3-3 protein epsilon

    Participant: 14-3-3 protein epsilon

    Accession: EBI-11012013

    Name: EBI-356498

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    1.852
    10
    -2
    0.0
    2.287
    10
    0
    0.0


    S
    Participant: 14-3-3 protein epsilon

    Participant: 14-3-3 protein epsilon

    Accession: EBI-11012013

    Name: EBI-356498

    Stoichiometry: 0.0

    F
    Participant: 14-3-3 protein epsilon

    Participant: 14-3-3 protein epsilon

    Accession: EBI-11012013

    Name: EBI-356498

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: 14-3-3 protein epsilon

    Participant: 14-3-3 protein epsilon

    Accession: EBI-11012013

    Name: EBI-356498

    Confidences:

    Type
    Value
    B+

    6
    EBI-2554690
     logo
    NSL1
    C1orf48
    MIS14

    [+2]
    Kinetochore-associated protein NSL1 homolog
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Kinetochore-associated protein NSL1 homolog

    Participant: Kinetochore-associated protein NSL1 homolog

    Accession: EBI-11012018

    Name: EBI-2554690

    Annotations:

    P
    Participant: Kinetochore-associated protein NSL1 homolog

    Participant: Kinetochore-associated protein NSL1 homolog

    Accession: EBI-11012018

    Name: EBI-2554690

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    2.225
    10
    -3
    0.0
    3.489
    10
    -3
    0.0


    S
    Participant: Kinetochore-associated protein NSL1 homolog

    Participant: Kinetochore-associated protein NSL1 homolog

    Accession: EBI-11012018

    Name: EBI-2554690

    Stoichiometry: 0.0

    F
    Participant: Kinetochore-associated protein NSL1 homolog

    Participant: Kinetochore-associated protein NSL1 homolog

    Accession: EBI-11012018

    Name: EBI-2554690

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Kinetochore-associated protein NSL1 homolog

    Participant: Kinetochore-associated protein NSL1 homolog

    Accession: EBI-11012018

    Name: EBI-2554690

    Confidences:

    Type
    Value
    B-

    7
    EBI-80690
     logo
    SMC1A
    Sb1.8
    SMC1L1

    [+4]
    Structural maintenance of chromosomes protein 1A
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Structural maintenance of chromosomes protein 1A

    Participant: Structural maintenance of chromosomes protein 1A

    Accession: EBI-11012023

    Name: EBI-80690

    Annotations:

    P
    Participant: Structural maintenance of chromosomes protein 1A

    Participant: Structural maintenance of chromosomes protein 1A

    Accession: EBI-11012023

    Name: EBI-80690

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    1.348
    10
    -3
    0.0
    6.47
    10
    -2
    0.0


    S
    Participant: Structural maintenance of chromosomes protein 1A

    Participant: Structural maintenance of chromosomes protein 1A

    Accession: EBI-11012023

    Name: EBI-80690

    Stoichiometry: 0.0

    F
    Participant: Structural maintenance of chromosomes protein 1A

    Participant: Structural maintenance of chromosomes protein 1A

    Accession: EBI-11012023

    Name: EBI-80690

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Structural maintenance of chromosomes protein 1A

    Participant: Structural maintenance of chromosomes protein 1A

    Accession: EBI-11012023

    Name: EBI-80690

    Confidences:

    Type
    Value
    B-

    8
    EBI-10981456
     logo
    HS6ST2
    PSEC0092
    Heparan-sulfate 6-O-sulfotransferase 2
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Heparan-sulfate 6-O-sulfotransferase 2

    Participant: Heparan-sulfate 6-O-sulfotransferase 2

    Accession: EBI-11012028

    Name: EBI-10981456

    Annotations:

    P
    Participant: Heparan-sulfate 6-O-sulfotransferase 2

    Participant: Heparan-sulfate 6-O-sulfotransferase 2

    Accession: EBI-11012028

    Name: EBI-10981456

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    2.334
    10
    -3
    0.0
    6.477
    10
    -4
    0.0


    S
    Participant: Heparan-sulfate 6-O-sulfotransferase 2

    Participant: Heparan-sulfate 6-O-sulfotransferase 2

    Accession: EBI-11012028

    Name: EBI-10981456

    Stoichiometry: 0.0

    F
    Participant: Heparan-sulfate 6-O-sulfotransferase 2

    Participant: Heparan-sulfate 6-O-sulfotransferase 2

    Accession: EBI-11012028

    Name: EBI-10981456

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Heparan-sulfate 6-O-sulfotransferase 2

    Participant: Heparan-sulfate 6-O-sulfotransferase 2

    Accession: EBI-11012028

    Name: EBI-10981456

    Confidences:

    Type
    Value
    B

    9
    EBI-10963103
     logo
    BDP1
    Transcription factor-like nuclear regulator
    Transcription factor IIIB 150

    [+3]
    Transcription factor TFIIIB component B'' homolog
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Transcription factor TFIIIB component B'' homolog

    Participant: Transcription factor TFIIIB component B'' homolog

    Accession: EBI-11012033

    Name: EBI-10963103

    Annotations:

    P
    Participant: Transcription factor TFIIIB component B'' homolog

    Participant: Transcription factor TFIIIB component B'' homolog

    Accession: EBI-11012033

    Name: EBI-10963103

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    1.063
    10
    -3
    0.0
    4.176
    10
    -4
    0.0


    S
    Participant: Transcription factor TFIIIB component B'' homolog

    Participant: Transcription factor TFIIIB component B'' homolog

    Accession: EBI-11012033

    Name: EBI-10963103

    Stoichiometry: 0.0

    F
    Participant: Transcription factor TFIIIB component B'' homolog

    Participant: Transcription factor TFIIIB component B'' homolog

    Accession: EBI-11012033

    Name: EBI-10963103

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Transcription factor TFIIIB component B'' homolog

    Participant: Transcription factor TFIIIB component B'' homolog

    Accession: EBI-11012033

    Name: EBI-10963103

    Confidences:

    Type
    Value
    B

    10
    EBI-2510162
     logo
    COPS7B
    JAB1-containing signalosome subunit 7b
    CSN7B
    COP9 signalosome complex subunit 7b
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: COP9 signalosome complex subunit 7b

    Participant: COP9 signalosome complex subunit 7b

    Accession: EBI-11012038

    Name: EBI-2510162

    Annotations:

    P
    Participant: COP9 signalosome complex subunit 7b

    Participant: COP9 signalosome complex subunit 7b

    Accession: EBI-11012038

    Name: EBI-2510162

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    3.535
    10
    -2
    0.0
    3.937
    10
    -2
    0.0


    S
    Participant: COP9 signalosome complex subunit 7b

    Participant: COP9 signalosome complex subunit 7b

    Accession: EBI-11012038

    Name: EBI-2510162

    Stoichiometry: 0.0

    F
    Participant: COP9 signalosome complex subunit 7b

    Participant: COP9 signalosome complex subunit 7b

    Accession: EBI-11012038

    Name: EBI-2510162

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: COP9 signalosome complex subunit 7b

    Participant: COP9 signalosome complex subunit 7b

    Accession: EBI-11012038

    Name: EBI-2510162

    Confidences:

    Type
    Value
    B-

    11
    EBI-1044383
     logo
    AP3B1
    Adaptor-related protein complex 3 subunit beta-1
    ADTB3A

    [+3]
    AP-3 complex subunit beta-1
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: AP-3 complex subunit beta-1

    Participant: AP-3 complex subunit beta-1

    Accession: EBI-11012043

    Name: EBI-1044383

    Annotations:

    P
    Participant: AP-3 complex subunit beta-1

    Participant: AP-3 complex subunit beta-1

    Accession: EBI-11012043

    Name: EBI-1044383

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    1.496
    10
    -3
    0.0
    2.329
    10
    -2
    0.0


    S
    Participant: AP-3 complex subunit beta-1

    Participant: AP-3 complex subunit beta-1

    Accession: EBI-11012043

    Name: EBI-1044383

    Stoichiometry: 0.0

    F
    Participant: AP-3 complex subunit beta-1

    Participant: AP-3 complex subunit beta-1

    Accession: EBI-11012043

    Name: EBI-1044383

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: AP-3 complex subunit beta-1

    Participant: AP-3 complex subunit beta-1

    Accession: EBI-11012043

    Name: EBI-1044383

    Confidences:

    Type
    Value
    B-

    12
    EBI-355867
     logo
    XPO1
    Chromosome region maintenance 1 protein homolog
    CRM1
    Exportin-1
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Exportin-1

    Participant: Exportin-1

    Accession: EBI-11012048

    Name: EBI-355867

    Annotations:

    P
    Participant: Exportin-1

    Participant: Exportin-1

    Accession: EBI-11012048

    Name: EBI-355867

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    8.925
    10
    -4
    0.0
    1.419
    10
    -1
    0.0


    S
    Participant: Exportin-1

    Participant: Exportin-1

    Accession: EBI-11012048

    Name: EBI-355867

    Stoichiometry: 0.0

    F
    Participant: Exportin-1

    Participant: Exportin-1

    Accession: EBI-11012048

    Name: EBI-355867

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Exportin-1

    Participant: Exportin-1

    Accession: EBI-11012048

    Name: EBI-355867

    Confidences:

    Type
    Value
    B-

    13
    EBI-2827999
     logo
    PCGF5
    RING finger protein 159
    RNF159
    Polycomb group RING finger protein 5
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Polycomb group RING finger protein 5

    Participant: Polycomb group RING finger protein 5

    Accession: EBI-11012053

    Name: EBI-2827999

    Annotations:

    P
    Participant: Polycomb group RING finger protein 5

    Participant: Polycomb group RING finger protein 5

    Accession: EBI-11012053

    Name: EBI-2827999

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    2.85
    10
    -2
    0.0
    1.976
    10
    -3
    0.0


    S
    Participant: Polycomb group RING finger protein 5

    Participant: Polycomb group RING finger protein 5

    Accession: EBI-11012053

    Name: EBI-2827999

    Stoichiometry: 0.0

    F
    Participant: Polycomb group RING finger protein 5

    Participant: Polycomb group RING finger protein 5

    Accession: EBI-11012053

    Name: EBI-2827999

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Polycomb group RING finger protein 5

    Participant: Polycomb group RING finger protein 5

    Accession: EBI-11012053

    Name: EBI-2827999

    Confidences:

    Type
    Value
    B-

    14
    EBI-10963872
     logo
    SPIRE2
    KIAA1832
    SPIR2
    Protein spire homolog 2
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Protein spire homolog 2

    Participant: Protein spire homolog 2

    Accession: EBI-11012058

    Name: EBI-10963872

    Annotations:

    P
    Participant: Protein spire homolog 2

    Participant: Protein spire homolog 2

    Accession: EBI-11012058

    Name: EBI-10963872

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    6.117
    10
    -4
    0.0
    1.021
    10
    -3
    0.0


    S
    Participant: Protein spire homolog 2

    Participant: Protein spire homolog 2

    Accession: EBI-11012058

    Name: EBI-10963872

    Stoichiometry: 0.0

    F
    Participant: Protein spire homolog 2

    Participant: Protein spire homolog 2

    Accession: EBI-11012058

    Name: EBI-10963872

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Protein spire homolog 2

    Participant: Protein spire homolog 2

    Accession: EBI-11012058

    Name: EBI-10963872

    Confidences:

    Type
    Value
    B-

    15
    EBI-1389808
     logo
    SDF4
    CAB45
    Stromal cell-derived factor 4

    [+1]
    45 kDa calcium-binding protein
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: 45 kDa calcium-binding protein

    Participant: 45 kDa calcium-binding protein

    Accession: EBI-11012063

    Name: EBI-1389808

    Annotations:

    Topic
    Text
    Low enrichment precludes background subtraction required for interaction stoichiometry calculation.
    Missing cellular copy number precludes calculation of relative abundance.
    B

    P
    Participant: 45 kDa calcium-binding protein

    Participant: 45 kDa calcium-binding protein

    Accession: EBI-11012063

    Name: EBI-1389808

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    No records found.


    S
    Participant: 45 kDa calcium-binding protein

    Participant: 45 kDa calcium-binding protein

    Accession: EBI-11012063

    Name: EBI-1389808

    Stoichiometry: 0.0

    F
    Participant: 45 kDa calcium-binding protein

    Participant: 45 kDa calcium-binding protein

    Accession: EBI-11012063

    Name: EBI-1389808

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: 45 kDa calcium-binding protein

    Participant: 45 kDa calcium-binding protein

    Accession: EBI-11012063

    Name: EBI-1389808

    Confidences:

    Type
    Value
    B

    16
    EBI-530012
     logo
    PCNT
    PCNT2
    KIAA0402

    [+2]
    Pericentrin
    Homo sapiens
    Organism Details

    Accession: EBI-874

    Name: human

    Description: Homo sapiens

    Cross References:

    Database
    Identifier
    Secondary identifier
    Qualifier
    human

    Expressed In Details

    Accession:

    Name:

    -
    prey
    Experimental role: prey
    Accession: EBI-58

    Name: prey

    Description: prey

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0498
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Molecule experimentally identified as being captured by a given bait.


    unspecified role
    Biological role: unspecified role
    Accession: EBI-77781

    Name: unspecified role

    Description: unspecified role

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    psi-mi
    MI:0499
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    Role not specified or not applicable to the data.


    protein
    Interactor type: protein
    Accession: EBI-619654

    Name: protein

    Description: protein

    Cross References:
    Database
    Identifier
    Secondary identifier
    Qualifier
    so
    SO:0000358
    -
    see-also
    psi-mi
    MI:0326
    -
    identity
    pubmed
    14755292
    -
    primary-reference


    Annotations:
    Topic
    Text
    definition
    A linear polymer of amino acids joined by peptide bonds in a specific sequence.


    A
    Participant: Pericentrin

    Participant: Pericentrin

    Accession: EBI-11012068

    Name: EBI-530012

    Annotations:

    P
    Participant: Pericentrin

    Participant: Pericentrin

    Accession: EBI-11012068

    Name: EBI-530012

    Parameters:

    Type
    Value
    Unit
    Base
    Exponent
    Uncertainty
    8.548
    10
    -4
    0.0
    5.519
    10
    -4
    0.0


    S
    Participant: Pericentrin

    Participant: Pericentrin

    Accession: EBI-11012068

    Name: EBI-530012

    Stoichiometry: 0.0

    F
    Participant: Pericentrin

    Participant: Pericentrin

    Accession: EBI-11012068

    Name: EBI-530012

    Features:

    Legend:
    A
    Annotation and Cross Reference  
    Feature Name
    Feature Type
    Detection Method
    Range positions
    More...
    No records found.

    C
    Participant: Pericentrin

    Participant: Pericentrin

    Accession: EBI-11012068

    Name: EBI-530012

    Confidences:

    Type
    Value
    B-


    Graphical Representation of Experimental Features