{"size":23,"totalNumberOfResults":23,"elements":[{"complexAC":"CPX-7681","complexName":"Kinetochore MIS12 complex, Nnf1a variant","organismName":"Drosophila melanogaster; 7227","description":"Required for normal chromosome alignment and segregation, kinetochore formation during mitosis, proper kinetochore microtubule attachments and for the spindle assembly checkpoint. Binds to the centromeric protein CENP-C (Q9VHP9) to create the foundation on which the mitotic kinetochore is constructed and enable the nucleation of the KMN (Knl1, Mis12, and Ndc80 complex) network.","predictedComplex":false,"interactors":[{"ac":"EBI-15108077","identifier":"Q9VS01","identifierLink":"https://www.uniprot.org/uniprotkb/Q9VS01/entry","name":"Mis12","description":null,"stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Drosophila melanogaster; 7227","xrefs":[]},{"ac":"EBI-174207","identifier":"Q7JZC9","identifierLink":"https://www.uniprot.org/uniprotkb/Q7JZC9/entry","name":"Nnf1a","description":null,"stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Drosophila melanogaster; 7227","xrefs":[]},{"ac":"EBI-9630827","identifier":"A4V2Z1","identifierLink":"https://www.uniprot.org/uniprotkb/A4V2Z1/entry","name":"nsl1","description":null,"stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Drosophila melanogaster; 7227","xrefs":[]}]},{"complexAC":"CPX-806","complexName":"Ndc80 complex","organismName":"Caenorhabditis elegans; 6239","description":"Crucial for the stable kinetochore-microtubule attachments that are needed to sustain the centromere tensions involved in achieving proper chromosome alignment in eukaryotic cells. Plays a role in chromosome alignment and microtubule-dependent control of Mad-1/Mad-2 (CPX-402) and dynein complexes at kinetochores, and also chromosome segregation in mitosis and meiosis and spindle checkpoint activity.\r\n\r\nThe complex is recruited to microtubules by kinetochore protein knl-1, which in turn is recruited by knl-3, a component of the MIND complex (CPX-807). Incorrect microtubule binding is controlled by phosphorylation of the ndc-80 subunit by ipl-1/Aurora kinase B. Phosphorylation of ndc-80 reduces the microtubule binding affinity of the complex. Erroneous microtubule-kinetochore attachments are also controlled by the Rzz complex (CPX-810), which interacts with the Ndc80 complex to inhibit irregular microtubule binding. This inhibition is relieved by recruitment of dynein to kinetochores by the coiled-coil protein Spindly/spdl-1.\r\n\r\nSynergistically enhances the affinity of the Ska-1 complex (CPX-811) for microtubules, which may furthermore allow the Ndc80 complex to track depolymerizing microtubules.","predictedComplex":false,"interactors":[{"ac":"EBI-1175834","identifier":"O45406","identifierLink":"https://www.uniprot.org/uniprotkb/O45406/entry","name":"kbp-3","description":"Kinetochore-binding protein 3","stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[]},{"ac":"EBI-1175844","identifier":"Q9N2X3","identifierLink":"https://www.uniprot.org/uniprotkb/Q9N2X3/entry","name":"kbp-4","description":null,"stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[]},{"ac":"EBI-314429","identifier":"Q17635","identifierLink":"https://www.uniprot.org/uniprotkb/Q17635/entry","name":"ndc-80","description":"Kinetochore protein ndc-80","stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[{"identifier":"PTHR10643","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-326288","identifier":"Q21952","identifierLink":"https://www.uniprot.org/uniprotkb/Q21952/entry","name":"him-10","description":"Kinetochore protein Nuf2 homolog","stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[{"identifier":"PTHR21650","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]}]},{"complexAC":"CPX-807","complexName":"Kinetochore Mis12 complex","organismName":"Caenorhabditis elegans; 6239","description":"Required for normal chromosome alignment and segregation, kinetochore formation during mitosis, proper kinetochore microtubule attachments and for the spindle assembly checkpoint. The complex plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules. Mis12/MIND is part of a tridentate linker layer, which also contains the Ndc80 complex.\r\n\r\nAlone, the Mis12/MIND complex does not bind to microtubules, but interaction with kinetochore protein knl-1 (P34278) increases the microtubule binding affinity. knl-3 recruits knl-1 to the complex which in turn recruits the Ndc80 complex to microtubules.","predictedComplex":false,"interactors":[{"ac":"EBI-1175918","identifier":"O76406","identifierLink":"https://www.uniprot.org/uniprotkb/O76406/entry","name":"knl-3","description":null,"stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[]},{"ac":"EBI-1175923","identifier":"Q9N3R7","identifierLink":"https://www.uniprot.org/uniprotkb/Q9N3R7/entry","name":"mis-12","description":null,"stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[]},{"ac":"EBI-1175928","identifier":"Q95QB8","identifierLink":"https://www.uniprot.org/uniprotkb/Q95QB8/entry","name":"kbp-1","description":null,"stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[]},{"ac":"EBI-1175933","identifier":"Q8MNT1","identifierLink":"https://www.uniprot.org/uniprotkb/Q8MNT1/entry","name":"kbp-2","description":null,"stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[]}]},{"complexAC":"CPX-808","complexName":"Knl-1/Mis12/MIND complex","organismName":"Caenorhabditis elegans; 6239","description":"Required for the stable kinetochore-microtubule attachments that are needed to sustain the centromere tensions involved in achieving proper chromosome alignment in eukaryotic cells.\r\n\r\nKinetochore protein knl-1 is essential for the kinetochore-microtubule interactions and increases the microtubule binding affinity of the Mis12 complex to aid in chromosome segregation during meiotic and mitotic cell division. knl-3 recruits knl-1 to the Mis12 complex which in turn recruits the Ndc80 complex to microtubules.","predictedComplex":false,"interactors":[{"ac":"EBI-1175918","identifier":"O76406","identifierLink":"https://www.uniprot.org/uniprotkb/O76406/entry","name":"knl-3","description":null,"stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[]},{"ac":"EBI-1175923","identifier":"Q9N3R7","identifierLink":"https://www.uniprot.org/uniprotkb/Q9N3R7/entry","name":"mis-12","description":null,"stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[]},{"ac":"EBI-1175928","identifier":"Q95QB8","identifierLink":"https://www.uniprot.org/uniprotkb/Q95QB8/entry","name":"kbp-1","description":null,"stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[]},{"ac":"EBI-1175933","identifier":"Q8MNT1","identifierLink":"https://www.uniprot.org/uniprotkb/Q8MNT1/entry","name":"kbp-2","description":null,"stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[]},{"ac":"EBI-313751","identifier":"P34278","identifierLink":"https://www.uniprot.org/uniprotkb/P34278/entry","name":"knl-1","description":"Outer kinetochore KNL1 complex subunit knl-1","stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[]}]},{"complexAC":"CPX-810","complexName":"RZZ complex","organismName":"Caenorhabditis elegans; 6239","description":"An essential component of the kinetochore required for both meiotic and mitotic spindle assembly checkpoints.  Plays a required role in spindle assembly checkpoint, blocking the metaphase-to-anaphase transition until all chromosomes are properly aligned in a metaphase plate. Targets mdf-2 of the mad-1/mad-2 complex (CPX-402) and also dynein/dynactin to kinetochores via the coiled-coil protein Spindly/spdl-1. This allows for the formation of stable spindle microtubule to kinetochore attachments, which in turn are required for activation of the spindle checkpoint and chromosome segregation. In order to prevent erroneous kinetochore attachments, the Rzz complex also interacts with the Ndc-80 complex (CPX-806) to inhibit the binding of the Ndc80 complex to microtubules. The recruitment of dynein to kinetochores by Spindly/spdl-1 relieves this inhibition.","predictedComplex":false,"interactors":[{"ac":"EBI-12556035","identifier":"Q20849","identifierLink":"https://www.uniprot.org/uniprotkb/Q20849/entry","name":"rod-1","description":"Kinetochore-associated protein rod-1","stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[{"identifier":"PTHR15688","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-12556047","identifier":"Q19642","identifierLink":"https://www.uniprot.org/uniprotkb/Q19642/entry","name":"czw-1","description":"Centromere/kinetochore protein zw10 homolog","stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[{"identifier":"PTHR12205","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-12556063","identifier":"Q95XP9","identifierLink":"https://www.uniprot.org/uniprotkb/Q95XP9/entry","name":"zwl-1","description":"Protein zwilch homolog","stochiometry":null,"interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[{"identifier":"PTHR15995","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]}]},{"complexAC":"CPX-811","complexName":"Ska1 complex","organismName":"Caenorhabditis elegans; 6239","description":"A microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The Ska1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex tracks with depolymerizing microtubule ends and associates with the microtubule lattice and curved protofilaments, and thus facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. Synergistically enhances the affinity of the Ndc80 complex (CPX-806) for microtubules, which may furthermore allow the Ndc80 complex to track depolymerizing microtubules.","predictedComplex":false,"interactors":[{"ac":"EBI-329888","identifier":"Q9XWS0","identifierLink":"https://www.uniprot.org/uniprotkb/Q9XWS0/entry","name":"ska-1","description":"SKA complex subunit 1","stochiometry":"minValue: 2, maxValue: 2","interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[{"identifier":"PTHR28573","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-329893","identifier":"Q9BI86","identifierLink":"https://www.uniprot.org/uniprotkb/Q9BI86/entry","name":"ska-3","description":null,"stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Caenorhabditis elegans; 6239","xrefs":[]}]},{"complexAC":"CPX-1041","complexName":"DASH complex","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","description":"Heterodecameric component of the kinetochore necessary for accurate chromosome segregation, supporting the dynamic attachment of mitotic chromosomes to the ends of shortening spindle microtubules. DASH forms closed rings around microtubules with a large gap between the DASH ring and the microtubule cylinder. A DASH-microtubule interface is believed to form, in which extensions from DASH rings reach across a gap between the ring and the microtubule and dock on the microtubule wall. DASH rings spontaneously oligomerize in the presence of microtubules of the mitotic spindle. DASH rings are processivity factors that allow kinetochores to translate along a single microtubule without dissociating. Each DASH ring may contain from 16-30 heterodecamers. The NDC80 complex (CPX-548) can simultaneously bind and bridge across two DASH complex rings through a tripartite interaction, each component of which is regulated by IPL1 kinase (P38991). This ensures a consistent spacing between rings. The complex may also may serve as a link between the kinetochore and the mitotic spindle.","predictedComplex":false,"interactors":[{"ac":"EBI-1379800","identifier":"P69852","identifierLink":"https://www.uniprot.org/uniprotkb/P69852/entry","name":"HSK3","description":"DASH complex subunit HSK3","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR28289","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-23268","identifier":"P53267","identifierLink":"https://www.uniprot.org/uniprotkb/P53267/entry","name":"DAM1","description":"DASH complex subunit DAM1","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR28113","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-23800","identifier":"P53168","identifierLink":"https://www.uniprot.org/uniprotkb/P53168/entry","name":"DUO1","description":"DASH complex subunit DUO1","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR28216","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-26401","identifier":"P36131","identifierLink":"https://www.uniprot.org/uniprotkb/P36131/entry","name":"SPC34","description":"DASH complex subunit SPC34","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[]},{"ac":"EBI-26515","identifier":"P36162","identifierLink":"https://www.uniprot.org/uniprotkb/P36162/entry","name":"DAD2","description":"DASH complex subunit DAD2","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR28036","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-26682","identifier":"P35734","identifierLink":"https://www.uniprot.org/uniprotkb/P35734/entry","name":"ASK1","description":"DASH complex subunit ASK1","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR28200","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-35662","identifier":"Q12248","identifierLink":"https://www.uniprot.org/uniprotkb/Q12248/entry","name":"DAD1","description":"DASH complex subunit DAD1","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR28025","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-38809","identifier":"Q03954","identifierLink":"https://www.uniprot.org/uniprotkb/Q03954/entry","name":"SPC19","description":"DASH complex subunit SPC19","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR28262","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-975376","identifier":"P69850","identifierLink":"https://www.uniprot.org/uniprotkb/P69850/entry","name":"DAD3","description":"DASH complex subunit DAD3","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR28017","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-975389","identifier":"P69851","identifierLink":"https://www.uniprot.org/uniprotkb/P69851/entry","name":"DAD4","description":"DASH complex subunit DAD4","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR28222","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]}]},{"complexAC":"CPX-1186","complexName":"Kinetochore MIS12 complex","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","description":"Required for normal chromosome alignment and segregation, kinetochore formation during mitosis, proper kinetochore microtubule attachments and for the spindle assembly checkpoint. The complex plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules. Mis12/MIND is part of a tridentate linker layer, which also contains the Ndc80 (CPX-548) and COMA (CPX-1187) complexes. Evidence suggests interactions between COMA, MIND, and Ndc80 complexes. The Mis12/MIND complex is a platform onto which outer kinetochore proteins assemble, including microtubule-binding proteins. It is proposed to have a distinct function with respect to force generation and microtubule attachment. In the absence of MIND, there is bipolar binding without the generation of sufficient pulling force to cause centromere stretching and transient sister-chromatid separation. MIND requires CBF3 complex for assembly onto centromeric DNA. Different combinations of MIND subunits have been found, which may reflect the regulated steps in kinetochore assembly.","predictedComplex":false,"interactors":[{"ac":"EBI-11606","identifier":"P39731","identifierLink":"https://www.uniprot.org/uniprotkb/P39731/entry","name":"MTW1","description":"Kinetochore-associated protein MTW1","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR14527","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-12098","identifier":"P47149","identifierLink":"https://www.uniprot.org/uniprotkb/P47149/entry","name":"NNF1","description":"Kinetochore-associated protein NNF1","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR15459","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-25398","identifier":"P40568","identifierLink":"https://www.uniprot.org/uniprotkb/P40568/entry","name":"DSN1","description":"Kinetochore-associated protein DSN1","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR14778","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-33666","identifier":"Q12143","identifierLink":"https://www.uniprot.org/uniprotkb/Q12143/entry","name":"NSL1","description":"Kinetochore-associated protein NSL1","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR31749","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]}]},{"complexAC":"CPX-1187","complexName":"COMA complex","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","description":"Heterotetrameric subcomplex of a larger central kinetochore CTF19 complex (CPX-1156).  COMA is part of a tridentate linker layer, which also contains the Ndc80 (CPX-548) and MIND (CPX-1186) complexes. Although the COMA, MIND, and Ndc80 complexes assemble independently, evidence suggests subsequent interactions. COMA is a platform onto which outer kinetochore proteins assemble, including microtubule-binding proteins. It is proposed to have a distinct function with respect to force generation and microtubule attachment. In the absence of COMA, there is bipolar binding without the generation of sufficient pulling force to cause centromere stretching and transient sister-chromatid separation. COMA requires CBF3 complex (CPX-1898) for assembly onto centromeric DNA. Different combinations of COMA subunits have been found, which may reflect the regulated steps in kinetochore assembly.","predictedComplex":false,"interactors":[{"ac":"EBI-20972","identifier":"P38313","identifierLink":"https://www.uniprot.org/uniprotkb/P38313/entry","name":"AME1","description":"Inner kinetochore subunit AME1","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[]},{"ac":"EBI-23429","identifier":"P53298","identifierLink":"https://www.uniprot.org/uniprotkb/P53298/entry","name":"OKP1","description":"Inner kinetochore subunit OKP1","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[]},{"ac":"EBI-32349","identifier":"Q06675","identifierLink":"https://www.uniprot.org/uniprotkb/Q06675/entry","name":"MCM21","description":"Inner kinetochore subunit MCM21","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[]},{"ac":"EBI-5199","identifier":"Q02732","identifierLink":"https://www.uniprot.org/uniprotkb/Q02732/entry","name":"CTF19","description":"Inner kinetochore subunit CTF19","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[]}]},{"complexAC":"CPX-548","complexName":"NDC80 complex","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","description":"Crucial for the stable kinetochore-microtubule attachments that are needed to sustain the centromere tensions involved in achieving proper chromosome alignment in eukaryotic cells, with a role in chromosome alignment and microtubule-dependent control of MAD1/MAD2 and dynein complexes at kinetochores. Loss-of-function mutation of any of 4 subunits in yeast causes disrupted kinetochore-microtubule binding and inactivation of the spindle checkpoint, leading to high rate of chromosome loss.","predictedComplex":false,"interactors":[{"ac":"EBI-12377","identifier":"P33895","identifierLink":"https://www.uniprot.org/uniprotkb/P33895/entry","name":"NUF2","description":"Kinetochore protein NUF2","stochiometry":null,"interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR21650","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-22458","identifier":"P40014","identifierLink":"https://www.uniprot.org/uniprotkb/P40014/entry","name":"SPC25","description":"Kinetochore protein SPC25","stochiometry":null,"interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[]},{"ac":"EBI-25247","identifier":"P40460","identifierLink":"https://www.uniprot.org/uniprotkb/P40460/entry","name":"NDC80","description":"Kinetochore protein NDC80","stochiometry":null,"interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR10643","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-27228","identifier":"Q04477","identifierLink":"https://www.uniprot.org/uniprotkb/Q04477/entry","name":"SPC24","description":"Kinetochore protein SPC24","stochiometry":null,"interactorType":"protein","organismName":"Saccharomyces cerevisiae (strain ATCC 204508 / S288c); 559292","xrefs":[{"identifier":"PTHR22142","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]}]},{"complexAC":"CPX-549","complexName":"Ndc80 complex","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","description":"Crucial for the stable kinetochore-microtubule attachments that are needed to sustain the centromere tensions involved in achieving proper chromosome alignment in eukaryotic cells, with a role in chromosome alignment and microtubule-dependent control of MAD1-MAD2 (CPX-961) and dynein complexes at kinetochores. Loss-of-function mutation of any of 4 subunits in yeast causes disrupted kinetochore-microtubule binding and inactivation of the spindle checkpoint, leading to high rate of chromosome loss. Ndc80 complex is rod-like with a globular head at each end. Ndc80 and Nuf2 form one head and part of rod and Spc24 and Spc25 form rest of rod and other head.","predictedComplex":false,"interactors":[{"ac":"EBI-1002524","identifier":"Q10198","identifierLink":"https://www.uniprot.org/uniprotkb/Q10198/entry","name":"ndc80","description":"Kinetochore protein ndc80","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR10643","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-1002565","identifier":"Q10173","identifierLink":"https://www.uniprot.org/uniprotkb/Q10173/entry","name":"nuf2","description":"Kinetochore protein nuf2","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR21650","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-1002585","identifier":"Q9UST6","identifierLink":"https://www.uniprot.org/uniprotkb/Q9UST6/entry","name":"spc24","description":"Kinetochore protein spc24","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR22142","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-1003107","identifier":"Q10430","identifierLink":"https://www.uniprot.org/uniprotkb/Q10430/entry","name":"spc25","description":"Kinetochore protein spc25","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR14281","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]}]},{"complexAC":"CPX-550","complexName":"Ndc80 complex","organismName":"Homo sapiens; 9606","description":"Crucial for the stable kinetochore-microtubule attachments that are needed to sustain the centromere tensions involved in achieving proper chromosome alignment in eukaryotic cells, with a role in chromosome alignment and microtubule-dependent control of MAD1/MAD2 and dynein complexes at kinetochores. The Ndc80 complex localizes to kinetochores and acts as direct or indirect kinetochore receptor for Mps1, Mad1, Mad2, Zw10 and Rod. The effects of Ndc80 depletion on the spindle checkpoint range from complete inactivation to sustained activation followed by cell death. This range of effects may be explained by penetrance of depletion phenotype. Ndc80 complex is rod-like with a globular head at each end. Ndc80 and Nuf2 form one head and part of rod and Spc24 and Spc25 form rest of rod and other head.\r\n\r\nKNL1 (CPX-5644), MIS12 (CPX-5643) and NCD80 form the KMN protein network.","predictedComplex":false,"interactors":[{"ac":"EBI-715849","identifier":"O14777","identifierLink":"https://www.uniprot.org/uniprotkb/O14777/entry","name":"NDC80","description":"Kinetochore protein NDC80 homolog","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Homo sapiens; 9606","xrefs":[{"identifier":"PTHR10643","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-724102","identifier":"Q9BZD4","identifierLink":"https://www.uniprot.org/uniprotkb/Q9BZD4/entry","name":"NUF2","description":"Kinetochore protein Nuf2","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Homo sapiens; 9606","xrefs":[{"identifier":"PTHR21650","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-999900","identifier":"Q8NBT2","identifierLink":"https://www.uniprot.org/uniprotkb/Q8NBT2/entry","name":"SPC24","description":"Kinetochore protein Spc24","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Homo sapiens; 9606","xrefs":[{"identifier":"PTHR22142","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-999909","identifier":"Q9HBM1","identifierLink":"https://www.uniprot.org/uniprotkb/Q9HBM1/entry","name":"SPC25","description":"Kinetochore protein Spc25","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Homo sapiens; 9606","xrefs":[{"identifier":"PTHR14281","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]}]},{"complexAC":"CPX-551","complexName":"Ndc80 complex","organismName":"Mus musculus; 10090","description":"Crucial for the stable kinetochore-microtubule attachments that are needed to sustain the centromere tensions involved in achieving proper chromosome alignment in eukaryotic cells, with a role in chromosome alignment and microtubule-dependent control of MAD1/MAD2 and dynein complexes at kinetochores. The Ndc80 complex localizes to kinetochores and acts as direct or indirect kinetochore receptor for Mps1, Mad1, Mad2, Zw10 and Rod. The effects of Ndc80 depletion on the spindle checkpoint range from complete inactivation to sustained activation followed by cell death. This range of effects may be explained by penetrance of depletion phenotype. Ndc80 complex is rod-like with a globular head at each end. Ndc80 and Nuf2 form one head and part of rod and Spc24 and Spc25 form rest of rod and other head. (By similarity).","predictedComplex":false,"interactors":[{"ac":"EBI-1209376","identifier":"Q99P69","identifierLink":"https://www.uniprot.org/uniprotkb/Q99P69/entry","name":"Nuf2","description":"Kinetochore protein Nuf2","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Mus musculus; 10090","xrefs":[{"identifier":"PTHR21650","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-1209394","identifier":"Q9D083","identifierLink":"https://www.uniprot.org/uniprotkb/Q9D083/entry","name":"Spc24","description":"Kinetochore protein Spc24","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Mus musculus; 10090","xrefs":[{"identifier":"PTHR22142","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-1209414","identifier":"Q3UA16","identifierLink":"https://www.uniprot.org/uniprotkb/Q3UA16/entry","name":"Spc25","description":"Kinetochore protein Spc25","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Mus musculus; 10090","xrefs":[{"identifier":"PTHR14281","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-309872","identifier":"Q9D0F1","identifierLink":"https://www.uniprot.org/uniprotkb/Q9D0F1/entry","name":"Ndc80","description":"Kinetochore protein NDC80 homolog","stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Mus musculus; 10090","xrefs":[{"identifier":"PTHR10643","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]}]},{"complexAC":"CPX-5643","complexName":"Kinetochore MIS12 complex","organismName":"Homo sapiens; 9606","description":"Required for normal chromosome alignment and segregation, kinetochore formation during mitosis, proper kinetochore microtubule attachments and for the spindle assembly checkpoint. The complex plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules.\r\n\r\nKNL1 (CPX-5644), MIS12 and NDC80 (CPX-550) form the KMN protein network.","predictedComplex":false,"interactors":[{"ac":"EBI-1001144","identifier":"Q9H410","identifierLink":"https://www.uniprot.org/uniprotkb/Q9H410/entry","name":"DSN1","description":"Kinetochore-associated protein DSN1 homolog","stochiometry":null,"interactorType":"protein","organismName":"Homo sapiens; 9606","xrefs":[{"identifier":"PTHR14778","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-1001205","identifier":"Q9H081","identifierLink":"https://www.uniprot.org/uniprotkb/Q9H081/entry","name":"MIS12","description":"Protein MIS12 homolog","stochiometry":null,"interactorType":"protein","organismName":"Homo sapiens; 9606","xrefs":[{"identifier":"PTHR14527","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-2554690","identifier":"Q96IY1","identifierLink":"https://www.uniprot.org/uniprotkb/Q96IY1/entry","name":"NSL1","description":"Kinetochore-associated protein NSL1 homolog","stochiometry":null,"interactorType":"protein","organismName":"Homo sapiens; 9606","xrefs":[{"identifier":"PTHR31749","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-713832","identifier":"Q6P1K2","identifierLink":"https://www.uniprot.org/uniprotkb/Q6P1K2/entry","name":"PMF1","description":"Polyamine-modulated factor 1","stochiometry":null,"interactorType":"protein","organismName":"Homo sapiens; 9606","xrefs":[{"identifier":"PTHR15459","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]}]},{"complexAC":"CPX-5645","complexName":"KMN complex","organismName":"Homo sapiens; 9606","description":"Part of the protein architecture within kinetochores that links centromeric DNA to the plus ends of spindle microtubules.","predictedComplex":false,"interactors":[{"ac":"EBI-1209326","identifier":"CPX-550","identifierLink":"http://www.ebi.ac.uk/complexportal/complex/CPX-550","name":"Ndc80 complex","description":"Ndc80 complex","stochiometry":null,"interactorType":"stable complex","organismName":"Homo sapiens; 9606","xrefs":[]},{"ac":"EBI-25468341","identifier":"CPX-5643","identifierLink":"http://www.ebi.ac.uk/complexportal/complex/CPX-5643","name":"Kinetochore MIS12 complex","description":null,"stochiometry":null,"interactorType":"stable complex","organismName":"Homo sapiens; 9606","xrefs":[]},{"ac":"EBI-25468806","identifier":"CPX-5644","identifierLink":"http://www.ebi.ac.uk/complexportal/complex/CPX-5644","name":"Kinetochore KNL1 complex","description":null,"stochiometry":null,"interactorType":"stable complex","organismName":"Homo sapiens; 9606","xrefs":[]}]},{"complexAC":"CPX-5701","complexName":"Kinetochore MIS12 complex","organismName":"Mus musculus; 10090","description":"Required for normal chromosome alignment and segregation, kinetochore formation during mitosis, proper kinetochore microtubule attachments and for the spindle assembly checkpoint. The complex plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules\r\n\r\nKNL1 (CPX-5702), MIS12 and NDC80 (CPX-551) form the KMN protein network.","predictedComplex":false,"interactors":[{"ac":"EBI-25495179","identifier":"Q8K305","identifierLink":"https://www.uniprot.org/uniprotkb/Q8K305/entry","name":"Nsl1","description":"Kinetochore-associated protein NSL1 homolog","stochiometry":null,"interactorType":"protein","organismName":"Mus musculus; 10090","xrefs":[{"identifier":"PTHR31749","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-2552696","identifier":"Q9CYC5","identifierLink":"https://www.uniprot.org/uniprotkb/Q9CYC5/entry","name":"Dsn1","description":"Kinetochore-associated protein DSN1 homolog","stochiometry":null,"interactorType":"protein","organismName":"Mus musculus; 10090","xrefs":[{"identifier":"PTHR14778","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-2553800","identifier":"Q9CY25","identifierLink":"https://www.uniprot.org/uniprotkb/Q9CY25/entry","name":"Mis12","description":"Protein MIS12 homolog","stochiometry":null,"interactorType":"protein","organismName":"Mus musculus; 10090","xrefs":[{"identifier":"PTHR14527","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-8572549","identifier":"Q9CPV5","identifierLink":"https://www.uniprot.org/uniprotkb/Q9CPV5/entry","name":"Pmf1","description":"Polyamine-modulated factor 1","stochiometry":null,"interactorType":"protein","organismName":"Mus musculus; 10090","xrefs":[{"identifier":"PTHR15459","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]}]},{"complexAC":"CPX-5703","complexName":"KMN complex","organismName":"Mus musculus; 10090","description":"Part of the protein architecture within kinetochores that links centromeric DNA to the plus ends of spindle microtubules.","predictedComplex":false,"interactors":[{"ac":"EBI-1209357","identifier":"CPX-551","identifierLink":"http://www.ebi.ac.uk/complexportal/complex/CPX-551","name":"Ndc80 complex","description":"Ndc80 complex","stochiometry":null,"interactorType":"stable complex","organismName":"Mus musculus; 10090","xrefs":[]},{"ac":"EBI-25495108","identifier":"CPX-5701","identifierLink":"http://www.ebi.ac.uk/complexportal/complex/CPX-5701","name":"Kinetochore MIS12 complex","description":null,"stochiometry":null,"interactorType":"stable complex","organismName":"Mus musculus; 10090","xrefs":[]},{"ac":"EBI-25495142","identifier":"CPX-5702","identifierLink":"http://www.ebi.ac.uk/complexportal/complex/CPX-5702","name":"Kinetochore KNL1 complex","description":null,"stochiometry":null,"interactorType":"stable complex","organismName":"Mus musculus; 10090","xrefs":[]}]},{"complexAC":"CPX-10081","complexName":"DASH complex","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","description":"Heterodecameric component of the kinetochore necessary for accurate chromosome segregation, supporting the dynamic attachment of mitotic chromosomes to the ends of shortening spindle microtubules. DASH forms closed rings around microtubules with a large gap between the DASH ring and the microtubule cylinder. A DASH-microtubule interface is believed to form, in which extensions from DASH rings reach across a gap between the ring and the microtubule and dock on the microtubule wall. DASH rings spontaneously oligomerize in the presence of microtubules of the mitotic spindle. DASH rings are processivity factors that allow kinetochores to translate along a single microtubule without dissociating. Each DASH ring may contain from 16-30 heterodecamers. The NDC80 complex (CPX-549) can simultaneously bind and bridge across two DASH complex rings through a tripartite interaction. This ensures a consistent spacing between rings. The complex may also may serve as a link between the kinetochore and the mitotic spindle. DASH is assembled and localized onto kinetochores specifically in mitosis.","predictedComplex":false,"interactors":[{"ac":"EBI-21242644","identifier":"Q9HDZ6","identifierLink":"https://www.uniprot.org/uniprotkb/Q9HDZ6/entry","name":"dam1","description":"DASH complex subunit dam1","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR28113","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-21242666","identifier":"P87297","identifierLink":"https://www.uniprot.org/uniprotkb/P87297/entry","name":"dad1","description":"DASH complex subunit dad1","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR28025","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-21244132","identifier":"O74372","identifierLink":"https://www.uniprot.org/uniprotkb/O74372/entry","name":"duo1","description":"DASH complex subunit duo1","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR28216","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-21244680","identifier":"O14285","identifierLink":"https://www.uniprot.org/uniprotkb/O14285/entry","name":"spc34","description":"DASH complex subunit spc34","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[]},{"ac":"EBI-55039384","identifier":"Q9UTG8","identifierLink":"https://www.uniprot.org/uniprotkb/Q9UTG8/entry","name":"dad2","description":"DASH complex subunit dad2","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR28036","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-55039405","identifier":"Q9P6S5","identifierLink":"https://www.uniprot.org/uniprotkb/Q9P6S5/entry","name":"ask1","description":"DASH complex subunit ask1","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR28200","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-55039427","identifier":"P62505","identifierLink":"https://www.uniprot.org/uniprotkb/P62505/entry","name":"dad3","description":"DASH complex subunit dad3","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR28017","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-55039445","identifier":"O94483","identifierLink":"https://www.uniprot.org/uniprotkb/O94483/entry","name":"dad5","description":"DASH complex subunit DAD5","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR28289","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-55039465","identifier":"Q50HP4","identifierLink":"https://www.uniprot.org/uniprotkb/Q50HP4/entry","name":"dad4","description":"DASH complex subunit dad4","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR28222","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-55039481","identifier":"Q50HP3","identifierLink":"https://www.uniprot.org/uniprotkb/Q50HP3/entry","name":"spc19","description":"DASH complex subunit spc19","stochiometry":null,"interactorType":"protein","organismName":"Schizosaccharomyces pombe (strain 972 / ATCC 24843); 284812","xrefs":[{"identifier":"PTHR28262","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]}]},{"complexAC":"CPX-8928","complexName":"Kinetochore MIS12 complex, Nnf1b variant","organismName":"Drosophila melanogaster; 7227","description":"Required for normal chromosome alignment and segregation, kinetochore formation during mitosis, proper kinetochore microtubule attachments and for the spindle assembly checkpoint. Binds to the centromeric protein CENP-C (Q9VHP9) to create the foundation on which the mitotic kinetochore is constructed and enable the nucleation of the KMN (Knl1, Mis12, and Ndc80 complex) network.","predictedComplex":false,"interactors":[{"ac":"EBI-15108077","identifier":"Q9VS01","identifierLink":"https://www.uniprot.org/uniprotkb/Q9VS01/entry","name":"Mis12","description":null,"stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Drosophila melanogaster; 7227","xrefs":[]},{"ac":"EBI-15108099","identifier":"Q8IPW3","identifierLink":"https://www.uniprot.org/uniprotkb/Q8IPW3/entry","name":"Nnf1b","description":null,"stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Drosophila melanogaster; 7227","xrefs":[]},{"ac":"EBI-9630827","identifier":"A4V2Z1","identifierLink":"https://www.uniprot.org/uniprotkb/A4V2Z1/entry","name":"nsl1","description":null,"stochiometry":"minValue: 1, maxValue: 1","interactorType":"protein","organismName":"Drosophila melanogaster; 7227","xrefs":[]}]},{"complexAC":"CPX-26614","complexName":"NDC80 complex","organismName":"Drosophila melanogaster; 7227","description":"Crucial for the stable kinetochore-microtubule attachments that are needed to sustain the centromere tensions involved in achieving proper chromosome alignment in eukaryotic cells, with a role in chromosome alignment and microtubule-dependent control of MAD1-MAD2 and dynein complexes at kinetochores.","predictedComplex":false,"interactors":[{"ac":"EBI-168789","identifier":"Q9VM45","identifierLink":"https://www.uniprot.org/uniprotkb/Q9VM45/entry","name":"Nuf2","description":null,"stochiometry":null,"interactorType":"protein","organismName":"Drosophila melanogaster; 7227","xrefs":[]},{"ac":"EBI-179943","identifier":"Q9VYB1","identifierLink":"https://www.uniprot.org/uniprotkb/Q9VYB1/entry","name":"Ndc80","description":"Kinetochore protein NDC80","stochiometry":null,"interactorType":"protein","organismName":"Drosophila melanogaster; 7227","xrefs":[{"identifier":"PTHR10643","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-67093163","identifier":"Q6IKI1","identifierLink":"https://www.uniprot.org/uniprotkb/Q6IKI1/entry","name":"Kmn2","description":null,"stochiometry":null,"interactorType":"protein","organismName":"Drosophila melanogaster; 7227","xrefs":[]},{"ac":"EBI-97707","identifier":"Q9V3V7","identifierLink":"https://www.uniprot.org/uniprotkb/Q9V3V7/entry","name":"Spc25","description":"Kinetochore protein Spc25","stochiometry":null,"interactorType":"protein","organismName":"Drosophila melanogaster; 7227","xrefs":[]}]},{"complexAC":"CPX-18561","complexName":"NDC80:BUB1:ZWINT:PMF1:SUGP1:SPC24:KNL1:NSL1:NUF2:MIS12:DSN1:SPC25","organismName":"Homo sapiens; 9606","description":"","predictedComplex":true,"interactors":[{"ac":"EBI-1001132","identifier":"O95229","identifierLink":"https://www.uniprot.org/uniprotkb/O95229/entry","name":"ZWINT","description":"Outer kinetochore KNL1 complex subunit ZWINT","stochiometry":null,"interactorType":"protein","organismName":"Homo sapiens; 9606","xrefs":[{"identifier":"PTHR31504","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-1001144","identifier":"Q9H410","identifierLink":"https://www.uniprot.org/uniprotkb/Q9H410/entry","name":"DSN1","description":"Kinetochore-associated protein DSN1 homolog","stochiometry":null,"interactorType":"protein","organismName":"Homo sapiens; 9606","xrefs":[{"identifier":"PTHR14778","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-1001161","identifier":"Q8NG31","identifierLink":"https://www.uniprot.org/uniprotkb/Q8NG31/entry","name":"KNL1","description":"Outer kinetochore KNL1 complex subunit KNL1","stochiometry":null,"interactorType":"protein","organismName":"Homo sapiens; 9606","xrefs":[{"identifier":"PTHR16520","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-1001205","identifier":"Q9H081","identifierLink":"https://www.uniprot.org/uniprotkb/Q9H081/entry","name":"MIS12","description":"Protein MIS12 homolog","stochiometry":null,"interactorType":"protein","organismName":"Homo sapiens; 9606","xrefs":[{"identifier":"PTHR14527","identifierLink":null,"database":"panther","qualifier":"orthology-group"}]},{"ac":"EBI-2554690","identifier":"Q96IY1","identifierLink":"https://www.uniprot.org/uniprotkb/Q96IY1/entry","name":"NSL1","description":"Kinetochore-associated protein NSL1 homolog","stochiometry":null,"interactorType":"protein","organismName":"Homo sapiens; 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