{"systematicName":"BARD1:BRCA1:BRCA2:BRCC3:BRE:RAD51","synonyms":["BRCA1-BRCA2- containing complex."],"functions":["A Ubc5-dependent E3 ubiquitin ligase complex involved in DNA repair, potentially by regulating factors involved in the process. It has a defined substrate specificity, with a strong preference for the nucleosome core histones H2A, H2B, H3 and H4. It co-localizes with, and efficiently ubiquitylates, the histone variant H2AX at sites of DNA damage. \r\n\r\n\r\n\r\n"],"properties":["After treatment with DNA damaging agents, BRCA1 is phosphorylated and there is an increased association with RAD51, linking the complex to DNA damage repair. The RAD51 subunit is more weakly associated with BRCC  than are other core subunits.\r\n\r\n"],"ac":"EBI-12686412","complexAc":"CPX-955","name":"BRCC E3 ubiquitin ligase complex","species":"Homo sapiens; 9606","ligands":[],"complexAssemblies":[],"diseases":["Breast cancer (EFO_0000305): A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.  . Mutations in BRCA1 are thought to be responsible for 45% of inherited breast cancer. Moreover, BRCA1 carriers have a 4-fold increased risk of colon cancer, whereas male carriers face a 3-fold increased risk of prostate cancer. Cells lacking BRCA1 show defects in DNA repair by homologous recombination."],"participants":[{"interactorAC":"EBI-12686710","identifier":"Q06609","identifierLink":"https://www.uniprot.org/uniprotkb/Q06609/entry","name":"RAD51","description":"DNA repair protein RAD51 homolog 1","stochiometry":null,"bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-12735505","participantId":"P51587","name":"RAD51 binding region","featureType":"sufficient to bind","featureTypeMI":"MI:0442","featureTypeDefinition":"Binding will occur when this sequence range is present within a molecule or part of a molecule. This region will contain the direct binding region but may be longer.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0442","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["1517-1551"],"linkedFeatures":["EBI-12735507"],"crossReferences":[]}],"otherFeatures":[]},{"interactorAC":"EBI-12686708","identifier":"P38398","identifierLink":"https://www.uniprot.org/uniprotkb/P38398/entry","name":"BRCA1","description":"Breast cancer type 1 susceptibility protein","stochiometry":null,"bioRole":"enzyme","bioRoleMI":"MI:0501","bioRoleDefinition":"Molecule catalyzing a modification on its interacting partner.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-12687149","participantId":"Q99728","name":"BRCA1 binding region","featureType":"sufficient to bind","featureTypeMI":"MI:0442","featureTypeDefinition":"Binding will occur when this sequence range is present within a molecule or part of a molecule. This region will contain the direct binding region but may be longer.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0442","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["26-119"],"linkedFeatures":["EBI-12687144"],"crossReferences":[{"database":"interpro","qualifier":"identical object in an external resource","identifier":"IPR013083","description":null,"searchURL":"https://www.ebi.ac.uk/interpro/entry/InterPro/IPR013083","dbMI":"MI:0449","qualifierMI":"MI:0356","dbdefinition":"InterPro combines a number of databases (referred to as member databases) that use different methodologies and a varying degree of biological information on well-characterised proteins to derive protein signatures that predict family membership and domain composition of naive protein sequences.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"}]},{"featureAc":"EBI-12686891","participantId":"P46736","name":"BRCA1 binding region","featureType":"sufficient to bind","featureTypeMI":"MI:0442","featureTypeDefinition":"Binding will occur when this sequence range is present within a molecule or part of a molecule. This region will contain the direct binding region but may be longer.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0442","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["?-?"],"linkedFeatures":["EBI-12686889"],"crossReferences":[]}],"otherFeatures":[]},{"interactorAC":"EBI-12686712","identifier":"Q99728","identifierLink":"https://www.uniprot.org/uniprotkb/Q99728/entry","name":"BARD1","description":"BRCA1-associated RING domain protein 1","stochiometry":null,"bioRole":"enzyme","bioRoleMI":"MI:0501","bioRoleDefinition":"Molecule catalyzing a modification on its interacting partner.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-12687144","participantId":"P38398","name":"BARD1 binding region","featureType":"sufficient to bind","featureTypeMI":"MI:0442","featureTypeDefinition":"Binding will occur when this sequence range is present within a molecule or part of a molecule. This region will contain the direct binding region but may be longer.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0442","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["1-109"],"linkedFeatures":["EBI-12687149"],"crossReferences":[{"database":"interpro","qualifier":"identical object in an external resource","identifier":"IPR013083","description":null,"searchURL":"https://www.ebi.ac.uk/interpro/entry/InterPro/IPR013083","dbMI":"MI:0449","qualifierMI":"MI:0356","dbdefinition":"InterPro combines a number of databases (referred to as member databases) that use different methodologies and a varying degree of biological information on well-characterised proteins to derive protein signatures that predict family membership and domain composition of naive protein sequences.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"}]}],"otherFeatures":[]},{"interactorAC":"EBI-12686711","identifier":"P46736","identifierLink":"https://www.uniprot.org/uniprotkb/P46736/entry","name":"BRCC3","description":"Lys-63-specific deubiquitinase BRCC36","stochiometry":null,"bioRole":"enzyme","bioRoleMI":"MI:0501","bioRoleDefinition":"Molecule catalyzing a modification on its interacting partner.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-12686889","participantId":"P38398","name":"BRCC3 binding region","featureType":"sufficient to bind","featureTypeMI":"MI:0442","featureTypeDefinition":"Binding will occur when this sequence range is present within a molecule or part of a molecule. This region will contain the direct binding region but may be longer.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0442","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["758-802"],"linkedFeatures":["EBI-12686891"],"crossReferences":[]}],"otherFeatures":[]},{"interactorAC":"EBI-12686709","identifier":"P51587","identifierLink":"https://www.uniprot.org/uniprotkb/P51587/entry","name":"BRCA2","description":"Breast cancer type 2 susceptibility protein","stochiometry":null,"bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-12735507","participantId":"Q06609","name":"BRCA2 binding region","featureType":"sufficient to bind","featureTypeMI":"MI:0442","featureTypeDefinition":"Binding will occur when this sequence range is present within a molecule or part of a molecule. This region will contain the direct binding region but may be longer.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0442","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["97-339"],"linkedFeatures":["EBI-12735505"],"crossReferences":[]}],"otherFeatures":[]},{"interactorAC":"EBI-12686707","identifier":"Q9NXR7","identifierLink":"https://www.uniprot.org/uniprotkb/Q9NXR7/entry","name":"BABAM2","description":"BRISC and BRCA1-A complex member 2","stochiometry":null,"bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[],"otherFeatures":[]}],"crossReferences":[{"database":"pubmed","qualifier":"additional information","identifier":"16707425","description":null,"searchURL":"http://europepmc.org/abstract/MED/16707425","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"wwpdb","qualifier":"subset","identifier":"1jm7","description":null,"searchURL":"http://www.pdbe.org/1jm7","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"HuMap","qualifier":"subset","identifier":"huMAP3_00528.1","description":null,"searchURL":"https://humap3.proteincomplexes.org/displayComplexes?complex_key=huMAP3_00528.1","dbMI":"MI:2424","qualifierMI":"MI:2179","dbdefinition":"HuMap is a machine learning framework to identify protein complexes from mass spectrometry and other large-scale interaction experiments. HuMap 3.0 is presented as a searchable web resource (https://humap3.proteincomplexes.org/) using data from >25,000 mass spectrometry experiments to identify nearly >15,000 human protein complexes.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"gene ontology","qualifier":"biological process","identifier":"GO:0071479","description":"cellular response to ionizing radiation","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0071479","dbMI":"MI:0448","qualifierMI":"MI:0359","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular process' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0359"},{"database":"pubmed","qualifier":"additional information","identifier":"12485996","description":null,"searchURL":"http://europepmc.org/abstract/MED/12485996","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"24832651","description":null,"searchURL":"http://europepmc.org/abstract/MED/24832651","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"14636569","description":null,"searchURL":"http://europepmc.org/abstract/MED/14636569","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"gene ontology","qualifier":"molecular function","identifier":"GO:0061630","description":"ubiquitin protein ligase activity","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0061630","dbMI":"MI:0448","qualifierMI":"MI:0355","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'molecular function' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0355"},{"database":"gene ontology","qualifier":"cellular component","identifier":"GO:0005634","description":"nucleus","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0005634","dbMI":"MI:0448","qualifierMI":"MI:0354","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular component' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0354"},{"database":"gene ontology","qualifier":"biological process","identifier":"GO:2000001","description":"regulation of DNA damage checkpoint","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:2000001","dbMI":"MI:0448","qualifierMI":"MI:0359","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular process' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0359"},{"database":"wwpdb","qualifier":"subset","identifier":"1n0w","description":null,"searchURL":"http://www.pdbe.org/1n0w","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"pubmed","qualifier":"additional information","identifier":"12442171","description":null,"searchURL":"http://europepmc.org/abstract/MED/12442171","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"gene ontology","qualifier":"cellular component","identifier":"GO:0000152","description":"nuclear ubiquitin ligase complex","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0000152","dbMI":"MI:0448","qualifierMI":"MI:0354","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular component' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0354"},{"database":"evidence ontology","qualifier":null,"identifier":"ECO:0005547","description":null,"searchURL":"http://www.ebi.ac.uk/ols/ontologies/ECO/terms?obo_id=ECO:0005547","dbMI":"MI:1331","qualifierMI":null,"dbdefinition":"The Evidence Ontology (ECO) describes types of scientific evidence within the realm of biological research that can arise from laboratory experiments, computational methods, manual literature curation, and other means.","qualifierDefinition":null,"qualifierUrl":null},{"database":"mondo","qualifier":"additional information","identifier":"MONDO:0004989","description":null,"searchURL":null,"dbMI":"MI:2410","qualifierMI":"MI:0361","dbdefinition":"A semi-automatically constructed ontology that merges in multiple disease resources to yield a coherent merged ontology.","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"intenz","qualifier":"identical object in an external resource","identifier":"3.4.19.12","description":null,"searchURL":"http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.19.12&t=exact&fields=ec","dbMI":"MI:0585","qualifierMI":"MI:0356","dbdefinition":"IntEnz is the name for the Integrated relational Enzyme database and is the official version of the Enzyme Nomenclature. The Enzyme Nomenclature comprises recommendations of the Nomenclature Committee of the International Union of Bio chemistry and Molecular Biology (NC-IUBMB) on the nomenclature and classification of enzyme-catalysed reactions. IntEnz is supported by NC-IUBMB and contains enzyme data curated and approved by this committee. The database IntEnz is available at.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"intenz","qualifier":"identical object in an external resource","identifier":"2.3.2.27","description":null,"searchURL":"http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.2.27&t=exact&fields=ec","dbMI":"MI:0585","qualifierMI":"MI:0356","dbdefinition":"IntEnz is the name for the Integrated relational Enzyme database and is the official version of the Enzyme Nomenclature. The Enzyme Nomenclature comprises recommendations of the Nomenclature Committee of the International Union of Bio chemistry and Molecular Biology (NC-IUBMB) on the nomenclature and classification of enzyme-catalysed reactions. IntEnz is supported by NC-IUBMB and contains enzyme data curated and approved by this committee. The database IntEnz is available at.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"complex portal","qualifier":"complex-primary","identifier":"CPX-955","description":null,"searchURL":"http://www.ebi.ac.uk/complexportal/complex/CPX-955","dbMI":"MI:2279","qualifierMI":"MI:2282","dbdefinition":"The Complex Portal is a manually curated, encyclopaedic resource of macromolecular complexes from a number of key model organisms, entered into the IntAct molecular interaction database . Data includes protein-only complexes as well as protein-small molecule and protein-nucleic acid complexes. All complexes are derived from physical molecular interaction evidences extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background. All complexes are tagged with Evidence and Conclusion Ontology codes to indicate the type of evidence available for each entry.","qualifierDefinition":"Complex object unique primary identifier that is assigned to a complex in the Complex Portal.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2282"},{"database":"signor","qualifier":"identical object in an external resource","identifier":"SIGNOR-C295","description":null,"searchURL":"http://signor.uniroma2.it/relation_result.php?id=SIGNOR-C295","dbMI":"MI:2214","qualifierMI":"MI:0356","dbdefinition":"SIGNOR, the SIGnaling Network Open Resource, organizes and stores in a structured format signaling information published in the scientific literature. The captured information is stored as binary causative relationships between biological entities and can be represented graphically as activity flow. The signaling information is mapped to the human proteome even if the experimental evidence is based on experiments on mammalian model organisms.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"}],"institution":"IntAct","institutionURL":"http://www.ebi.ac.uk/intact","agonists":[],"antagonists":[],"comments":[],"predictedComplex":false,"evidenceType":{"identifier":"ECO:0005547","description":"inferred by curator","searchURL":"http://www.ebi.ac.uk/ols/ontologies/ECO/terms?obo_id=ECO:0005547","confidenceScore":3},"releaseDates":["2017-01-27"]}