{"systematicName":"INS dimer","synonyms":[],"functions":["Insulin is a protein hormone that regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of glucose from the blood into liver, fat and skeletal muscle cells"],"properties":["Insulin is produced and stored in the body as a hexamer, three dimeric units which form s symmetrical molecule with zinc atoms present on the axis of symmetry.\r\n"],"ac":"EBI-12685322","complexAc":"CPX-943","name":"Insulin complex","species":"Homo sapiens; 9606","ligands":[],"complexAssemblies":["Heterodimer"],"diseases":["Permanent neonatal diabetes mellitus (PNDM) is a monogenic form of neonatal diabetes (NDM, see this term) characterized by persistent hyperglycemia within the first 12 months of life in general, requiring continuous insulin treatment [MONDO:0100164].","MODY (maturity-onset diabetes of the young) is a rare, familial, clinically and genetically heterogeneous form of diabetes characterized by young age of onset (generally 10-45 years of age) with maintenance of endogenous insulin production, lack of pancreatic beta-cell autoimmunity, absence of obesity and insulin resistance and extra-pancreatic manifestations in some subtypes.[MONDO:0018911]."],"participants":[{"interactorAC":"EBI-12685863","identifier":"P01308-PRO_0000015821","identifierLink":"https://www.uniprot.org/uniprotkb/P01308-PRO_0000015821/entry","name":"INS","description":"Insulin A chain","stochiometry":"minValue: 1, maxValue: 1","bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-13641905","participantId":"P01308-PRO_0000015819","name":"cys-7","featureType":"disulfide crosslinked residues","featureTypeMI":null,"featureTypeDefinition":"A protein modification that crosslinks two cysteine residues by formation of a disulfide bond.","featureTypeUrl":null,"featureRole":"observed-ptm","featureRoleMI":"MI:0925","featureRoleDefinition":"Post translational modification observed on a protein in the context of an interaction.","featureRoleUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0925","ranges":["7-7"],"linkedFeatures":["EBI-13641909"],"crossReferences":[]},{"featureAc":"EBI-13641907","participantId":"P01308-PRO_0000015819","name":"cys-19","featureType":"disulfide crosslinked residues","featureTypeMI":null,"featureTypeDefinition":"A protein modification that crosslinks two cysteine residues by formation of a disulfide bond.","featureTypeUrl":null,"featureRole":"observed-ptm","featureRoleMI":"MI:0925","featureRoleDefinition":"Post translational modification observed on a protein in the context of an interaction.","featureRoleUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0925","ranges":["19-19"],"linkedFeatures":["EBI-13641911"],"crossReferences":[]}],"otherFeatures":[]},{"interactorAC":"EBI-12685861","identifier":"P01308-PRO_0000015819","identifierLink":"https://www.uniprot.org/uniprotkb/P01308-PRO_0000015819/entry","name":"INS","description":"Insulin B chain","stochiometry":"minValue: 1, maxValue: 1","bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-13641909","participantId":"P01308-PRO_0000015821","name":"cys-7","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["7-7"],"linkedFeatures":["EBI-13641905"],"crossReferences":[]},{"featureAc":"EBI-13641911","participantId":"P01308-PRO_0000015821","name":"cys-20","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["20-20"],"linkedFeatures":["EBI-13641907"],"crossReferences":[]}],"otherFeatures":[]}],"crossReferences":[{"database":"efo","qualifier":"additional information","identifier":"MONDO:0018911","description":null,"searchURL":"http://www.ebi.ac.uk/ols/ontologies/efo/terms?obo_id=MONDO:0018911","dbMI":"MI:1337","qualifierMI":"MI:0361","dbdefinition":"The Experimental Factor Ontology provides a systematic description of many experimental variables, combining parts of several biological ontologies to additional new terms.","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"gene ontology","qualifier":"molecular function","identifier":"GO:0005179","description":"hormone activity","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0005179","dbMI":"MI:0448","qualifierMI":"MI:0355","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'molecular function' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0355"},{"database":"gene ontology","qualifier":"molecular function","identifier":"GO:0005158","description":"insulin receptor binding","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0005158","dbMI":"MI:0448","qualifierMI":"MI:0355","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'molecular function' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0355"},{"database":"gene ontology","qualifier":"biological process","identifier":"GO:0042593","description":"glucose homeostasis","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0042593","dbMI":"MI:0448","qualifierMI":"MI:0359","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular process' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0359"},{"database":"gene ontology","qualifier":"cellular component","identifier":"GO:0005615","description":"extracellular space","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0005615","dbMI":"MI:0448","qualifierMI":"MI:0354","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular component' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0354"},{"database":"efo","qualifier":"additional information","identifier":"MONDO:0100164","description":null,"searchURL":"http://www.ebi.ac.uk/ols/ontologies/efo/terms?obo_id=MONDO:0100164","dbMI":"MI:1337","qualifierMI":"MI:0361","dbdefinition":"The Experimental Factor Ontology provides a systematic description of many experimental variables, combining parts of several biological ontologies to additional new terms.","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"evidence ontology","qualifier":null,"identifier":"ECO:0000353","description":null,"searchURL":"http://www.ebi.ac.uk/ols/ontologies/ECO/terms?obo_id=ECO:0000353","dbMI":"MI:1331","qualifierMI":null,"dbdefinition":"The Evidence Ontology (ECO) describes types of scientific evidence within the realm of biological research that can arise from laboratory experiments, computational methods, manual literature curation, and other means.","qualifierDefinition":null,"qualifierUrl":null},{"database":"pubmed","qualifier":"additional information","identifier":"10489447","description":null,"searchURL":"http://europepmc.org/abstract/MED/10489447","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"23416304","description":null,"searchURL":"http://europepmc.org/abstract/MED/23416304","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"intact","qualifier":"Experimental evidence that interaction occurs","identifier":"EBI-8437891","description":null,"searchURL":"http://www.ebi.ac.uk/intact/query/EBI-8437891","dbMI":"MI:0469","qualifierMI":null,"dbdefinition":"INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.","qualifierDefinition":null,"qualifierUrl":null},{"database":"qsproteome","qualifier":"identical object in an external resource","identifier":"QS181395","description":null,"searchURL":"https://qsproteome.org/entry/QS181395","dbMI":"MI:2443","qualifierMI":"MI:0356","dbdefinition":"QSProteome is a centralized, community-driven structural biology resource that hosts over 35,000 predicted oligomeric protein complex models, covering more than 42,000 genes across multiple species. It prevents redundant modeling by allowing researchers to track existing predictions and provides clear quality metrics (pLDDT, ipTM, PAE) to assess model reliability. Each entry includes interactive 3D visualization, functional annotations, and links to databases such as BioCyc, ComplexPortal, PDB, and UniProt, integrating computational predictions with experimental data. The platform also supports community curation, enabling users to refine models and contribute to the expanding structural proteome.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"reactome","qualifier":"identical object in an external resource","identifier":"R-HSA-74674","description":null,"searchURL":"http://www.reactome.org/content/detail/R-HSA-74674","dbMI":"MI:0467","qualifierMI":"MI:0356","dbdefinition":"The Reactome project is a collaboration among Cold Spring Harbor Laboratory, The European Bioinformatics Institute, and The Gene Ontology Consortium to develop a curated resource of core pathways and reactions in human biology.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"wwpdb","qualifier":"identical object in an external resource","identifier":"1b9e","description":null,"searchURL":"http://www.pdbe.org/1b9e","dbMI":"MI:0805","qualifierMI":"MI:0356","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"complex portal","qualifier":"complex-primary","identifier":"CPX-943","description":null,"searchURL":"http://www.ebi.ac.uk/complexportal/complex/CPX-943","dbMI":"MI:2279","qualifierMI":"MI:2282","dbdefinition":"The Complex Portal is a manually curated, encyclopaedic resource of macromolecular complexes from a number of key model organisms, entered into the IntAct molecular interaction database . Data includes protein-only complexes as well as protein-small molecule and protein-nucleic acid complexes. All complexes are derived from physical molecular interaction evidences extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background. All complexes are tagged with Evidence and Conclusion Ontology codes to indicate the type of evidence available for each entry.","qualifierDefinition":"Complex object unique primary identifier that is assigned to a complex in the Complex Portal.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2282"}],"institution":"ceitec","institutionURL":"www.ceitec.eu/","agonists":[],"antagonists":[],"comments":[],"predictedComplex":false,"evidenceType":{"identifier":"ECO:0000353","description":"physical interaction evidence","searchURL":"http://www.ebi.ac.uk/ols/ontologies/ECO/terms?obo_id=ECO:0000353","confidenceScore":5},"releaseDates":["2022-07-11"]}