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The resulting RAD51-ssDNA filament invades the intact sister chromatid and the strand is extended through the action of DNA polymerases."],"properties":["PALB2 acts as a molecular scaffold for complex formation. The C‐terminal region of PALB2 consists of a seven‐bladed WD40‐type beta‐propeller, which provides the binding site for the N‐terminus of BRCA2."],"ac":"EBI-12560041","complexAc":"CPX-845","name":"BRCA1-PALB2-BRCA2 homologous recombination DNA repair complex","species":"Homo sapiens; 9606","ligands":[],"complexAssemblies":[],"diseases":["Fanconi anemia (FA) [MONDO:0019391]: a hereditary DNA repair disorder characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors.","Hereditary breast and ovarian cancer syndrome [MONDO:0003582]: an autosomal dominant inherited syndrome caused by mutations in the BRCA1 or BRCA2 genes. Patients are at high risk of developing breast cancer, particularly before the age of fifty, high risk of developing a second primary breast cancer, and high risk of developing both breast and ovarian cancer.","Familial pancreatic carcinoma [MONDO:0015278]: defined by the presence of pancreatic cancer (PC) in two or more first-degree relatives.","Hereditary breast cancer [MONDO:0016419]: breast carcinoma that has developed in relatives of patients with history of breast carcinoma."],"participants":[{"interactorAC":"EBI-12560052","identifier":"Q86YC2","identifierLink":"https://www.uniprot.org/uniprotkb/Q86YC2/entry","name":"PALB2","description":"Partner and localizer of BRCA2","stochiometry":"minValue: 1, maxValue: 1","bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-12560148","participantId":"P51587","name":"PALB2 binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. 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