{"systematicName":"CASP1:NLRP1:PYCARD","synonyms":["CASP1-NALP1 inflammasome","CASP1-NLRP1 inflammasome","NALP1 inflammasome (ASC independent)","NALP1 inflammasome","NLRP1 inflammasome"],"functions":["A pro-inflammatory thiol protease complex that is activated in response to pathogen infections and toxins (e.g. Anthrax lethal toxin). Primarily acts in monocytes and macrophages. \r\n\r\nActivating platform for Caspase-1 (CPX-952) through proximity-induced self-cleavage in an ATP-dependent reaction.\r\n\r\nActivated Caspase-1 cleaves interleukins 1beta (IL1B, P01584) and IL18 (Q14116) releasing the mature cytokines which are involved in a variety of inflammatory processes and is also involved in pyroptosis of macrophages, a special case of cell death, associated with infection by intracellular pathogens where it cleaves GSDMD (P57764). \r\n\r\nBelongs to the family of Inflammasomes that includes NLRP3 inflammasome (CPX-4141), NLRC4 inflammasome (CPX-4144), AIM2 inflammasome (CPX-4142) and Pyrin inflammasome (CPX-4143).\r\n\r\nSingle-nucleotide polymorphisms in the NLRP1 gene are associated with vitiligo."],"properties":["The NLRP1 inflammasome is a multimeric protein complex that typically comprises nucleator (NLRP1), adaptor (PYCARD), and effector (zymogen procaspase-1) subunits. \r\n\r\nNLRP1 belongs to the family of Nod-like receptors (NLRs), which constitutes 22 members in humans and 34 in mice. The FIIND (domain with function to find) region in NLRP1 is involved in homomerization and autocatalytic cleavage in this region occurs constitutively, prior to activation signals. Once cleaved, N- and C-terminal products remain associated. NLRP1 oligomerizes via its NACHT domain and interacts with PYCARD through its CARD domain. PYCARD then links procaspase-1 to the complex via CARD-CARD interactions.\r\n\r\nThe complex has a ring-like organization, with an outer diameter of 13 nm and an inner diameter of 4 nm, with density peaks arranged in two concentric rings. The complex is a multimeric structure and the most likely ratio of CASP1:NLRP1:PYCARD is 1:1:1 but 2:1:1 is also a possibility.\r\n\r\nThis complex can be formed without the adapter protein PYCARD, with lower catalytic activity. In this case, the CARD domain of procaspase-1 binds the CARD domain of NLRP1.\r\n\r\n\r\n\r\n"],"ac":"EBI-21018494","complexAc":"CPX-4082","name":"NLRP1 inflammasome","species":"Homo sapiens; 9606","ligands":[],"complexAssemblies":[],"diseases":["Vitiligo [EFO:0004208]: A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached."],"participants":[{"interactorAC":"EBI-21018523","identifier":"Q9C000","identifierLink":"https://www.uniprot.org/uniprotkb/Q9C000/entry","name":"NLRP1","description":"NACHT, LRR and PYD domains-containing protein 1","stochiometry":null,"bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-21019711","participantId":"Q9ULZ3","name":"NLRP1 binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["1-91"],"linkedFeatures":["EBI-21018524"],"crossReferences":[{"database":"interpro","qualifier":"identical object in an external resource","identifier":"IPR004020","description":null,"searchURL":"https://www.ebi.ac.uk/interpro/entry/InterPro/IPR004020","dbMI":"MI:0449","qualifierMI":"MI:0356","dbdefinition":"InterPro combines a number of databases (referred to as member databases) that use different methodologies and a varying degree of biological information on well-characterised proteins to derive protein signatures that predict family membership and domain composition of naive protein sequences.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"}]}],"otherFeatures":[]},{"interactorAC":"EBI-21018519","identifier":"P29466","identifierLink":"https://www.uniprot.org/uniprotkb/P29466/entry","name":"CASP1","description":"Caspase-1","stochiometry":null,"bioRole":"enzyme","bioRoleMI":"MI:0501","bioRoleDefinition":"Molecule catalyzing a modification on its interacting partner.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-21019700","participantId":"Q9ULZ3","name":"CASP1 binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["113-195"],"linkedFeatures":["EBI-21018520"],"crossReferences":[{"database":"interpro","qualifier":"identical object in an external resource","identifier":"IPR001315","description":null,"searchURL":"https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001315","dbMI":"MI:0449","qualifierMI":"MI:0356","dbdefinition":"InterPro combines a number of databases (referred to as member databases) that use different methodologies and a varying degree of biological information on well-characterised proteins to derive protein signatures that predict family membership and domain composition of naive protein sequences.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"}]}],"otherFeatures":[]},{"interactorAC":"EBI-21019699","identifier":"Q9ULZ3","identifierLink":"https://www.uniprot.org/uniprotkb/Q9ULZ3/entry","name":"PYCARD","description":"Apoptosis-associated speck-like protein containing a CARD","stochiometry":null,"bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-21018520","participantId":"P29466","name":"PYCARD binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["1-91"],"linkedFeatures":["EBI-21019700"],"crossReferences":[{"database":"interpro","qualifier":"identical object in an external resource","identifier":"IPR001315","description":null,"searchURL":"https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001315","dbMI":"MI:0449","qualifierMI":"MI:0356","dbdefinition":"InterPro combines a number of databases (referred to as member databases) that use different methodologies and a varying degree of biological information on well-characterised proteins to derive protein signatures that predict family membership and domain composition of naive protein sequences.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"}]},{"featureAc":"EBI-21018524","participantId":"Q9C000","name":"PYCARD binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["1374-1463"],"linkedFeatures":["EBI-21019711"],"crossReferences":[{"database":"interpro","qualifier":"identical object in an external resource","identifier":"IPR001315","description":null,"searchURL":"https://www.ebi.ac.uk/interpro/entry/InterPro/IPR001315","dbMI":"MI:0449","qualifierMI":"MI:0356","dbdefinition":"InterPro combines a number of databases (referred to as member databases) that use different methodologies and a varying degree of biological information on well-characterised proteins to derive protein signatures that predict family membership and domain composition of naive protein sequences.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"}]}],"otherFeatures":[]}],"crossReferences":[{"database":"pubmed","qualifier":"additional information","identifier":"30872531","description":null,"searchURL":"http://europepmc.org/abstract/MED/30872531","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"gene ontology","qualifier":"biological process","identifier":"GO:0070269","description":"pyroptosis","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0070269","dbMI":"MI:0448","qualifierMI":"MI:0359","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular process' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0359"},{"database":"pubmed","qualifier":"additional information","identifier":"20007570","description":null,"searchURL":"http://europepmc.org/abstract/MED/20007570","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"gene ontology","qualifier":"biological process","identifier":"GO:0050729","description":"positive regulation of inflammatory response","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0050729","dbMI":"MI:0448","qualifierMI":"MI:0359","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular process' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0359"},{"database":"pubmed","qualifier":"additional information","identifier":"20303873","description":null,"searchURL":"http://europepmc.org/abstract/MED/20303873","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"29196474","description":null,"searchURL":"http://europepmc.org/abstract/MED/29196474","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"25879281","description":null,"searchURL":"http://europepmc.org/abstract/MED/25879281","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"gene ontology","qualifier":"molecular function","identifier":"GO:0004197","description":"cysteine-type endopeptidase activity","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0004197","dbMI":"MI:0448","qualifierMI":"MI:0355","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'molecular function' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0355"},{"database":"gene ontology","qualifier":"cellular component","identifier":"GO:0072558","description":"NLRP1 inflammasome complex","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0072558","dbMI":"MI:0448","qualifierMI":"MI:0354","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular component' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0354"},{"database":"gene ontology","qualifier":"cellular component","identifier":"GO:0005737","description":"cytoplasm","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0005737","dbMI":"MI:0448","qualifierMI":"MI:0354","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular component' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0354"},{"database":"gene ontology","qualifier":"biological process","identifier":"GO:0032731","description":"positive regulation of interleukin-1 beta production","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0032731","dbMI":"MI:0448","qualifierMI":"MI:0359","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular process' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0359"},{"database":"gene ontology","qualifier":"biological process","identifier":"GO:0002221","description":"pattern recognition receptor signaling pathway","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0002221","dbMI":"MI:0448","qualifierMI":"MI:0359","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular process' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0359"},{"database":"pubmed","qualifier":"additional information","identifier":"17349957","description":null,"searchURL":"http://europepmc.org/abstract/MED/17349957","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"gene ontology","qualifier":"molecular function","identifier":"GO:0061133","description":"endopeptidase activator activity","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0061133","dbMI":"MI:0448","qualifierMI":"MI:0355","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'molecular function' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0355"},{"database":"wwpdb","qualifier":"subset","identifier":"2fqq","description":null,"searchURL":"http://www.pdbe.org/2fqq","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"2h48","description":null,"searchURL":"http://www.pdbe.org/2h48","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1rww","description":null,"searchURL":"http://www.pdbe.org/1rww","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1rwx","description":null,"searchURL":"http://www.pdbe.org/1rwx","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1sc3","description":null,"searchURL":"http://www.pdbe.org/1sc3","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"2h4w","description":null,"searchURL":"http://www.pdbe.org/2h4w","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"2h4y","description":null,"searchURL":"http://www.pdbe.org/2h4y","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"2h51","description":null,"searchURL":"http://www.pdbe.org/2h51","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"2h54","description":null,"searchURL":"http://www.pdbe.org/2h54","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"2hbq","description":null,"searchURL":"http://www.pdbe.org/2hbq","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"2hbr","description":null,"searchURL":"http://www.pdbe.org/2hbr","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"emdb","qualifier":"subset","identifier":"EMD-8902","description":null,"searchURL":"https://www.ebi.ac.uk/emdb/EMD-8902","dbMI":"MI:0936","qualifierMI":"MI:2179","dbdefinition":"The Electron Microscopy Data Bank (EMDB) contains experimentally determined three-dimensional maps and associated experimental data and files.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"emdb","qualifier":"subset","identifier":"EMD-5830","description":null,"searchURL":"https://www.ebi.ac.uk/emdb/EMD-5830","dbMI":"MI:0936","qualifierMI":"MI:2179","dbdefinition":"The Electron Microscopy Data Bank (EMDB) contains experimentally determined three-dimensional maps and associated experimental data and files.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"3j63","description":null,"searchURL":"http://www.pdbe.org/3j63","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1bmq","description":null,"searchURL":"http://www.pdbe.org/1bmq","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"6n1h","description":null,"searchURL":"http://www.pdbe.org/6n1h","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1ibc","description":null,"searchURL":"http://www.pdbe.org/1ibc","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1ice","description":null,"searchURL":"http://www.pdbe.org/1ice","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1rwk","description":null,"searchURL":"http://www.pdbe.org/1rwk","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1rwm","description":null,"searchURL":"http://www.pdbe.org/1rwm","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1rwn","description":null,"searchURL":"http://www.pdbe.org/1rwn","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1rwo","description":null,"searchURL":"http://www.pdbe.org/1rwo","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1rwp","description":null,"searchURL":"http://www.pdbe.org/1rwp","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1rwv","description":null,"searchURL":"http://www.pdbe.org/1rwv","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"gene ontology","qualifier":"cellular component","identifier":"GO:0005730","description":"nucleolus","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0005730","dbMI":"MI:0448","qualifierMI":"MI:0354","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular component' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0354"},{"database":"wwpdb","qualifier":"subset","identifier":"1sc1","description":null,"searchURL":"http://www.pdbe.org/1sc1","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"1sc4","description":null,"searchURL":"http://www.pdbe.org/1sc4","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"2hby","description":null,"searchURL":"http://www.pdbe.org/2hby","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"2hbz","description":null,"searchURL":"http://www.pdbe.org/2hbz","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"3d6f","description":null,"searchURL":"http://www.pdbe.org/3d6f","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"3d6h","description":null,"searchURL":"http://www.pdbe.org/3d6h","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"3d6m","description":null,"searchURL":"http://www.pdbe.org/3d6m","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"5mmv","description":null,"searchURL":"http://www.pdbe.org/5mmv","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"3e4c","description":null,"searchURL":"http://www.pdbe.org/3e4c","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"3ns7","description":null,"searchURL":"http://www.pdbe.org/3ns7","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"5fna","description":null,"searchURL":"http://www.pdbe.org/5fna","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"5mtk","description":null,"searchURL":"http://www.pdbe.org/5mtk","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"6bz9","description":null,"searchURL":"http://www.pdbe.org/6bz9","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"wwpdb","qualifier":"subset","identifier":"6f6r","description":null,"searchURL":"http://www.pdbe.org/6f6r","dbMI":"MI:0805","qualifierMI":"MI:2179","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. It implies the object is part of a cross-referenced entity (usually a complex).","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2179"},{"database":"evidence ontology","qualifier":null,"identifier":"ECO:0005547","description":null,"searchURL":"http://www.ebi.ac.uk/ols/ontologies/ECO/terms?obo_id=ECO:0005547","dbMI":"MI:1331","qualifierMI":null,"dbdefinition":"The Evidence Ontology (ECO) describes types of scientific evidence within the realm of biological research that can arise from laboratory experiments, computational methods, manual literature curation, and other means.","qualifierDefinition":null,"qualifierUrl":null},{"database":"mondo","qualifier":"additional information","identifier":"MONDO:0008661","description":null,"searchURL":null,"dbMI":"MI:2410","qualifierMI":"MI:0361","dbdefinition":"A semi-automatically constructed ontology that merges in multiple disease resources to yield a coherent merged ontology.","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"complex portal","qualifier":"complex-primary","identifier":"CPX-4082","description":null,"searchURL":"http://www.ebi.ac.uk/complexportal/complex/CPX-4082","dbMI":"MI:2279","qualifierMI":"MI:2282","dbdefinition":"The Complex Portal is a manually curated, encyclopaedic resource of macromolecular complexes from a number of key model organisms, entered into the IntAct molecular interaction database . Data includes protein-only complexes as well as protein-small molecule and protein-nucleic acid complexes. All complexes are derived from physical molecular interaction evidences extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background. All complexes are tagged with Evidence and Conclusion Ontology codes to indicate the type of evidence available for each entry.","qualifierDefinition":"Complex object unique primary identifier that is assigned to a complex in the Complex Portal.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2282"},{"database":"intenz","qualifier":"identical object in an external resource","identifier":"3.4.22.36","description":null,"searchURL":"http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.22.36&t=exact&fields=ec","dbMI":"MI:0585","qualifierMI":"MI:0356","dbdefinition":"IntEnz is the name for the Integrated relational Enzyme database and is the official version of the Enzyme Nomenclature. The Enzyme Nomenclature comprises recommendations of the Nomenclature Committee of the International Union of Bio chemistry and Molecular Biology (NC-IUBMB) on the nomenclature and classification of enzyme-catalysed reactions. IntEnz is supported by NC-IUBMB and contains enzyme data curated and approved by this committee. The database IntEnz is available at.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"signor","qualifier":"identical object in an external resource","identifier":"SIGNOR-C224","description":null,"searchURL":"http://signor.uniroma2.it/relation_result.php?id=SIGNOR-C224","dbMI":"MI:2214","qualifierMI":"MI:0356","dbdefinition":"SIGNOR, the SIGnaling Network Open Resource, organizes and stores in a structured format signaling information published in the scientific literature. The captured information is stored as binary causative relationships between biological entities and can be represented graphically as activity flow. The signaling information is mapped to the human proteome even if the experimental evidence is based on experiments on mammalian model organisms.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"}],"institution":"IntAct","institutionURL":"http://www.ebi.ac.uk/intact","agonists":[],"antagonists":[],"comments":["The complex appears to have different localization in different cell types."],"predictedComplex":false,"evidenceType":{"identifier":"ECO:0005547","description":"inferred by curator","searchURL":"http://www.ebi.ac.uk/ols/ontologies/ECO/terms?obo_id=ECO:0005547","confidenceScore":3},"releaseDates":["2019-07-19"]}