{"systematicName":"KRAS:PIK3CA","synonyms":["RASK2-PIK3CA complex","KRAS2-PIK3CA complex","KRAS-PI3KA complex"],"functions":["Phosphatidylinositol 3-kinase (PI3K) activation complex which acts as a molecular switch maintaining cellular homeostasis by coordinating a broad range of essential processes, including glucose absorption, anabolic metabolism, cell growth, and survival. Once active, PIK3CA phosphorylates its substrate, PIP2 (ChEBI:18348), to generate PIP3 (ChEBI:16618), which in turn activates downstream signalling, including the AKT-mTOR pathway. This promotes cell survival by inhibiting pro-apoptotic factors, stimulate cell growth and proliferation through mTORC1 activation, and regulates metabolism by enhancing glucose uptake and glycolysis.\r\n\r\nMutations in KRAS and PIK3CA are implicated in various cancers. Notably, in endometrial carcinogenesis, KRAS and PIK3CA mutations are mutually exclusive and inversely correlated, suggesting that alterations in either gene may play equivalent roles in tumour development."],"properties":["In its basal state, PIK3CA exists as an autoinhibited heterodimer composed of a p85-alpha regulatory subunit and a p110-alpha catalytic subunit, in which p85-alpha suppresses the catalytic activity of p110-alpha. KRAS engages p110-alpha, recruiting PIK3CA to the plasma membrane and relieving its autoinhibition. "],"ac":"EBI-67189474","complexAc":"CPX-26694","name":"KRAS-PIK3CA cellular-homeostasis regulatory complex","species":"Homo sapiens; 9606","ligands":[],"complexAssemblies":["Heterodimer"],"diseases":["Colorectal cancer [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history."],"participants":[{"interactorAC":"EBI-67189483","identifier":"P01116","identifierLink":"https://www.uniprot.org/uniprotkb/P01116/entry","name":"KRAS","description":"GTPase KRas","stochiometry":"minValue: 1, maxValue: 1","bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-67189550","participantId":"P42336-PRO_0000088785","name":"KRAS binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["?-?"],"linkedFeatures":["EBI-67189552"],"crossReferences":[]}],"otherFeatures":[]},{"interactorAC":"EBI-67189484","identifier":"P42336-PRO_0000088785","identifierLink":"https://www.uniprot.org/uniprotkb/P42336-PRO_0000088785/entry","name":"PIK3CA","description":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform","stochiometry":"minValue: 1, maxValue: 1","bioRole":"enzyme","bioRoleMI":"MI:0501","bioRoleDefinition":"Molecule catalyzing a modification on its interacting partner.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-67189552","participantId":"P01116","name":"PIK3CA-p110alpha binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. 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