{"systematicName":"2xKRAS:2xRAF1","synonyms":["RASK2-RAF1 complex","KRAS2-RAF complex"],"functions":["Serine/threonine kinase complex which regulates diverse cellular processes, including proliferation, differentiation, and survival. Active, membrane-bound KRAS binds and recruits RAF1 to the membrane, initiating the canonical KRAS-RAF1-MEK-ERK, MAPK signalling cascade. RAF1 activation (via dimerization) leads to sequential phosphorylation of MEK and then ERK. Activated ERK moves into the nucleus to regulate gene expression through phosphorylation of transcription factors. \r\n\r\nMutations that maintain KRAS in its active, GTP-bound state drive constitutive MAPK pathway signalling and promote oncogenesis; KRAS represents the most frequently mutated oncogene in human cancers, accounting for approximately 80% of RAS-driven tumors."],"properties":["RAF1 has three conserved regions CR1-CR3: 1) CR1 contains the KRAS-binding domain (RBD) and cysteine-rich domain (CRD); 2) CR2 has a 14-3-3 recognition site; and 3) CR3 (C-terminal), contains the kinase domain and a second 14-3-3 binding site. In the inactive state, a 14-3-3 dimer binds phosphorylated serines in CR2 and CR3 to maintain autoinhibition. Membrane-bound active GTP-KRAS binds the RBD of RAF1, while KRAS's CRD interacts with phospholipids, relieving autoinhibition and enabling RAF activation.\r\n\r\nDimerization of RAF1 through its N‐terminal RBD or RBD-CRD domains differentially alters the dimerization mode of KRAS on both anionic and neutral membranes, facilitating the stabilization of a heterotetrameric KRAS-RAF complexes formed via dimerization of preformed RAS-RAF heterodimers."],"ac":"EBI-67189117","complexAc":"CPX-26693","name":"KRAS-RAF1, MAPK-cascade signal initiation complex","species":"Homo sapiens; 9606","ligands":[],"complexAssemblies":["Heterotetramer"],"diseases":["Colorectal cancer [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history."],"participants":[{"interactorAC":"EBI-67202597","identifier":"CHEBI:37565","identifierLink":"http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:37565","name":"gtp(4-)","description":"GTP(4-)","stochiometry":null,"bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"small molecule","interactorTypeMI":"MI:0328","interactorTypeDefinition":"Molecule not part of or directly encoded by the genome, encompasses any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer, etc., identifiable as a separately distinguishable entity.","linkedFeatures":[{"featureAc":"EBI-67202598","participantId":"P01116","name":"GTP binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["1-169"],"linkedFeatures":["EBI-67202600"],"crossReferences":[]}],"otherFeatures":[]},{"interactorAC":"EBI-67189127","identifier":"P04049","identifierLink":"https://www.uniprot.org/uniprotkb/P04049/entry","name":"RAF1","description":"RAF proto-oncogene serine/threonine-protein kinase","stochiometry":"minValue: 2, maxValue: 2","bioRole":"enzyme","bioRoleMI":"MI:0501","bioRoleDefinition":"Molecule catalyzing a modification on its interacting partner.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-67189377","participantId":"P01116","name":"RAF1 binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["1-169"],"linkedFeatures":["EBI-67189374"],"crossReferences":[]},{"featureAc":"EBI-67189464","participantId":"P04049","name":"CRD binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["52-131"],"linkedFeatures":["EBI-67189457"],"crossReferences":[{"database":"interpro","qualifier":"identical object in an external resource","identifier":"IPR003116","description":null,"searchURL":"https://www.ebi.ac.uk/interpro/entry/InterPro/IPR003116","dbMI":"MI:0449","qualifierMI":"MI:0356","dbdefinition":"InterPro combines a number of databases (referred to as member databases) that use different methodologies and a varying degree of biological information on well-characterised proteins to derive protein signatures that predict family membership and domain composition of naive protein sequences.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"}]}],"otherFeatures":[]},{"interactorAC":"EBI-67189126","identifier":"P01116","identifierLink":"https://www.uniprot.org/uniprotkb/P01116/entry","name":"KRAS","description":"GTPase KRas","stochiometry":"minValue: 2, maxValue: 2","bioRole":"enzyme","bioRoleMI":"MI:0501","bioRoleDefinition":"Molecule catalyzing a modification on its interacting partner.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-67189374","participantId":"P04049","name":"KRAS binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["52-131"],"linkedFeatures":["EBI-67189377"],"crossReferences":[{"database":"interpro","qualifier":"identical object in an external resource","identifier":"IPR003116","description":null,"searchURL":"https://www.ebi.ac.uk/interpro/entry/InterPro/IPR003116","dbMI":"MI:0449","qualifierMI":"MI:0356","dbdefinition":"InterPro combines a number of databases (referred to as member databases) that use different methodologies and a varying degree of biological information on well-characterised proteins to derive protein signatures that predict family membership and domain composition of naive protein sequences.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"}]},{"featureAc":"EBI-67189472","participantId":"P01116","name":"KRAS binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["1-169"],"linkedFeatures":["EBI-67189467"],"crossReferences":[]},{"featureAc":"EBI-67202600","participantId":"CHEBI:37565","name":"KRAS binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["10-18","29-35","59-60","116-119"],"linkedFeatures":["EBI-67202598"],"crossReferences":[]}],"otherFeatures":[]}],"crossReferences":[{"database":"intact","qualifier":"Experimental evidence that interaction occurs","identifier":"EBI-22297513","description":null,"searchURL":"http://www.ebi.ac.uk/intact/query/EBI-22297513","dbMI":"MI:0469","qualifierMI":null,"dbdefinition":"INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.","qualifierDefinition":null,"qualifierUrl":null},{"database":"evidence ontology","qualifier":null,"identifier":"ECO:0000353","description":null,"searchURL":"http://www.ebi.ac.uk/ols/ontologies/ECO/terms?obo_id=ECO:0000353","dbMI":"MI:1331","qualifierMI":null,"dbdefinition":"The Evidence Ontology (ECO) describes types of scientific evidence within the realm of biological research that can arise from laboratory experiments, computational methods, manual literature curation, and other means.","qualifierDefinition":null,"qualifierUrl":null},{"database":"pubmed","qualifier":"additional information","identifier":"37516774","description":null,"searchURL":"http://europepmc.org/abstract/MED/37516774","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"39138901","description":null,"searchURL":"http://europepmc.org/abstract/MED/39138901","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"33608534","description":null,"searchURL":"http://europepmc.org/abstract/MED/33608534","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"34830757","description":null,"searchURL":"http://europepmc.org/abstract/MED/34830757","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"gene ontology","qualifier":"cellular component","identifier":"GO:1902554","description":"serine/threonine protein kinase complex","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:1902554","dbMI":"MI:0448","qualifierMI":"MI:0354","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular component' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0354"},{"database":"gene ontology","qualifier":"biological process","identifier":"GO:0043410","description":"positive regulation of MAPK cascade","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0043410","dbMI":"MI:0448","qualifierMI":"MI:0359","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular process' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0359"},{"database":"gene ontology","qualifier":"molecular function","identifier":"GO:0004674","description":"protein serine/threonine kinase activity","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0004674","dbMI":"MI:0448","qualifierMI":"MI:0355","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'molecular function' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0355"},{"database":"omim","qualifier":"additional information","identifier":"601626","description":null,"searchURL":"http://www.omim.org/entry/601626","dbMI":"MI:0480","qualifierMI":"MI:0361","dbdefinition":"Online Mendelian Inheritance in Man (OMIM) is a catalogue of human genes and genetic disorders, with links to literature references, sequence records, maps, and related databases.\nhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"efo","qualifier":"additional information","identifier":"MONDO:0012690","description":null,"searchURL":"http://www.ebi.ac.uk/ols/ontologies/efo/terms?obo_id=MONDO:0012690","dbMI":"MI:1337","qualifierMI":"MI:0361","dbdefinition":"The Experimental Factor Ontology provides a systematic description of many experimental variables, combining parts of several biological ontologies to additional new terms.","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"omim","qualifier":"additional information","identifier":"613659","description":null,"searchURL":"http://www.omim.org/entry/613659","dbMI":"MI:0480","qualifierMI":"MI:0361","dbdefinition":"Online Mendelian Inheritance in Man (OMIM) is a catalogue of human genes and genetic disorders, with links to literature references, sequence records, maps, and related databases.\nhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"omim","qualifier":"additional information","identifier":"607785","description":null,"searchURL":"http://www.omim.org/entry/607785","dbMI":"MI:0480","qualifierMI":"MI:0361","dbdefinition":"Online Mendelian Inheritance in Man (OMIM) is a catalogue of human genes and genetic disorders, with links to literature references, sequence records, maps, and related databases.\nhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"efo","qualifier":"additional information","identifier":"MONDO:0012371","description":null,"searchURL":"http://www.ebi.ac.uk/ols/ontologies/efo/terms?obo_id=MONDO:0012371","dbMI":"MI:1337","qualifierMI":"MI:0361","dbdefinition":"The Experimental Factor Ontology provides a systematic description of many experimental variables, combining parts of several biological ontologies to additional new terms.","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"38111008","description":null,"searchURL":"http://europepmc.org/abstract/MED/38111008","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"complex portal","qualifier":"complex-primary","identifier":"CPX-26693","description":null,"searchURL":"http://www.ebi.ac.uk/complexportal/complex/CPX-26693","dbMI":"MI:2279","qualifierMI":"MI:2282","dbdefinition":"The Complex Portal is a manually curated, encyclopaedic resource of macromolecular complexes from a number of key model organisms, entered into the IntAct molecular interaction database . Data includes protein-only complexes as well as protein-small molecule and protein-nucleic acid complexes. All complexes are derived from physical molecular interaction evidences extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background. All complexes are tagged with Evidence and Conclusion Ontology codes to indicate the type of evidence available for each entry.","qualifierDefinition":"Complex object unique primary identifier that is assigned to a complex in the Complex Portal.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2282"},{"database":"rhea","qualifier":"identical object in an external resource","identifier":"RHEA:17989","description":null,"searchURL":"https://www.rhea-db.org/reaction?id=RHEA:17989","dbMI":"MI:2344","qualifierMI":"MI:0356","dbdefinition":"Rhea is an expert curated resource of biochemical reactions designed for the annotation of enzymes and genome-scale metabolic networks and models. Rhea uses the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to precisely describe reactions participants and their chemical structures. All reactions are balanced for mass and charge and are linked to source literature, metabolic resources and other functional vocabularies such as the enzyme classification of the NC-IUBMB.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"rhea","qualifier":"identical object in an external resource","identifier":"RHEA:46608","description":null,"searchURL":"https://www.rhea-db.org/reaction?id=RHEA:46608","dbMI":"MI:2344","qualifierMI":"MI:0356","dbdefinition":"Rhea is an expert curated resource of biochemical reactions designed for the annotation of enzymes and genome-scale metabolic networks and models. Rhea uses the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to precisely describe reactions participants and their chemical structures. All reactions are balanced for mass and charge and are linked to source literature, metabolic resources and other functional vocabularies such as the enzyme classification of the NC-IUBMB.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"intenz","qualifier":"identical object in an external resource","identifier":"2.7.11.1","description":null,"searchURL":"http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.11.1&t=exact&fields=ec","dbMI":"MI:0585","qualifierMI":"MI:0356","dbdefinition":"IntEnz is the name for the Integrated relational Enzyme database and is the official version of the Enzyme Nomenclature. The Enzyme Nomenclature comprises recommendations of the Nomenclature Committee of the International Union of Bio chemistry and Molecular Biology (NC-IUBMB) on the nomenclature and classification of enzyme-catalysed reactions. IntEnz is supported by NC-IUBMB and contains enzyme data curated and approved by this committee. The database IntEnz is available at.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"wwpdb","qualifier":"identical object in an external resource","identifier":"6XHA","description":null,"searchURL":"http://www.pdbe.org/6XHA","dbMI":"MI:0805","qualifierMI":"MI:0356","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"wwpdb","qualifier":"identical object in an external resource","identifier":"6XGV","description":null,"searchURL":"http://www.pdbe.org/6XGV","dbMI":"MI:0805","qualifierMI":"MI:0356","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"wwpdb","qualifier":"identical object in an external resource","identifier":"6XI7","description":null,"searchURL":"http://www.pdbe.org/6XI7","dbMI":"MI:0805","qualifierMI":"MI:0356","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"wwpdb","qualifier":"identical object in an external resource","identifier":"6XHB","description":null,"searchURL":"http://www.pdbe.org/6XHB","dbMI":"MI:0805","qualifierMI":"MI:0356","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"wwpdb","qualifier":"identical object in an external resource","identifier":"6XGU","description":null,"searchURL":"http://www.pdbe.org/6XGU","dbMI":"MI:0805","qualifierMI":"MI:0356","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"wwpdb","qualifier":"identical object in an external resource","identifier":"6VJJ","description":null,"searchURL":"http://www.pdbe.org/6VJJ","dbMI":"MI:0805","qualifierMI":"MI:0356","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"wwpdb","qualifier":"identical object in an external resource","identifier":"8T75","description":null,"searchURL":"http://www.pdbe.org/8T75","dbMI":"MI:0805","qualifierMI":"MI:0356","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"wwpdb","qualifier":"identical object in an external resource","identifier":"8T74","description":null,"searchURL":"http://www.pdbe.org/8T74","dbMI":"MI:0805","qualifierMI":"MI:0356","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"wwpdb","qualifier":"identical object in an external resource","identifier":"8EPW","description":null,"searchURL":"http://www.pdbe.org/8EPW","dbMI":"MI:0805","qualifierMI":"MI:0356","dbdefinition":"The Worldwide Protein Data Bank (wwPDB) consists of organizations that act as deposition, data processing and distribution centers for PDB data. The founding members are RCSB PDB (USA), MSD-EBI (Europe) and PDBj (Japan). The BMRB (USA) group joined the wwPDB in 2006. The mission of the wwPDB is to maintain a single Protein Data Bank Archive of macromolecular structural data that is freely and publicly available to the global community.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"rhea","qualifier":"identical object in an external resource","identifier":"RHEA:19669","description":null,"searchURL":"https://www.rhea-db.org/reaction?id=RHEA:19669","dbMI":"MI:2344","qualifierMI":"MI:0356","dbdefinition":"Rhea is an expert curated resource of biochemical reactions designed for the annotation of enzymes and genome-scale metabolic networks and models. Rhea uses the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to precisely describe reactions participants and their chemical structures. All reactions are balanced for mass and charge and are linked to source literature, metabolic resources and other functional vocabularies such as the enzyme classification of the NC-IUBMB.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"intenz","qualifier":"identical object in an external resource","identifier":"3.6.5.2","description":null,"searchURL":"http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.5.2&t=exact&fields=ec","dbMI":"MI:0585","qualifierMI":"MI:0356","dbdefinition":"IntEnz is the name for the Integrated relational Enzyme database and is the official version of the Enzyme Nomenclature. The Enzyme Nomenclature comprises recommendations of the Nomenclature Committee of the International Union of Bio chemistry and Molecular Biology (NC-IUBMB) on the nomenclature and classification of enzyme-catalysed reactions. IntEnz is supported by NC-IUBMB and contains enzyme data curated and approved by this committee. The database IntEnz is available at.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"}],"institution":"IntAct","institutionURL":"http://www.ebi.ac.uk/intact","agonists":[],"antagonists":[],"comments":[],"predictedComplex":false,"evidenceType":{"identifier":"ECO:0000353","description":"physical interaction evidence","searchURL":"http://www.ebi.ac.uk/ols/ontologies/ECO/terms?obo_id=ECO:0000353","confidenceScore":5},"releaseDates":["2026-01-09"]}