{"systematicName":"SHOC2:KRAS:PPP1CA","synonyms":["SKP complex","KIAA0862-RASK2-PPP1CA complex","SHOC2-KRAS2-PPP1A complex"],"functions":["Holophosphatase complex which dephosphorylates members of RAF family proteins, RAF1 (P04049), BRAF (P15056) and ARAF (P10398) at key inhibitory phosphorylation sites Ser-259, Ser-365 and Ser-214, respectively, while eliminating inhibitory phosphorylation on RAF family proteins to potentiate MAPK signalling. Functions as a key regulator of RTK-RAS signalling, a pathway which regulates cell proliferation and survival through the MAP kinase cascade. \r\n\r\nMutations mapped to protein-protein interfaces in the complex impair complex formation and stabilization. Gain-of-function and loss-of-function mutations in SHOC2 are linked to driving RASopathy and RAS-driven cancers including colorectal cancers."],"properties":["Tripartite molecular structure in which a crescent-shaped SHOC2 acts as a scaffolding component to bind PPP1CA and KRAS through its Leucine-rich repeat region, and SHOC2 further interacts with a cryptic RVxF binding pocket in the N-terminal disordered region of PPP1CA. Initial complex formation is mediated by SHOC2-PPP1CA interactions and is stabilized by binding of GTP-loaded KRAS. KRAS activation leads to membrane localization of the SKP complex and dephosphorylation of RAF family proteins. KRAS binds SHOC2 with lower affinity than MRAS (O14807), and while MRAS can outcompete KRAS interactions with SHOC2, the interaction sites and dephosphorylation sites on RAF family members are conserved."],"ac":"EBI-61184731","complexAc":"CPX-26355","name":"SHOC2-KRAS-PPP1CA complex","species":"Homo sapiens; 9606","ligands":[],"complexAssemblies":["Heterotrimer"],"diseases":["RASopathy [EFO:1001502]: Developmental syndrome caused by germline mutations in genes that alter the RAS subfamily and mitogen-activated protein kinases that control signal transduction. Known rasopathies include Noonan syndrome, LEOPARD syndrome, Colstello syndrome, neurofibromatosis type 1 and autoimmune lymphoproliferative syndrome. RASopathy syndromes are characterized by congenital cardiac, skeletal, and cognitive deficits.","Cancer [MONDO:0004992]: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas."],"participants":[{"interactorAC":"EBI-61184761","identifier":"CHEBI:29035","identifierLink":"http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29035","name":"manganese(2+)","description":"Manganese (2+)","stochiometry":"minValue: 2, maxValue: 2","bioRole":"cofactor","bioRoleMI":"MI:0682","bioRoleDefinition":"A cofactor is a small molecule required for the catalysis of an enzyme.","interactorType":"small molecule","interactorTypeMI":"MI:0328","interactorTypeDefinition":"Molecule not part of or directly encoded by the genome, encompasses any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer, etc., identifiable as a separately distinguishable entity.","linkedFeatures":[{"featureAc":"EBI-61184771","participantId":"P62136","name":"Manganese binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["64-64","248-248","92-92","124-124","173-173"],"linkedFeatures":["EBI-61184762"],"crossReferences":[]}],"otherFeatures":[]},{"interactorAC":"EBI-61184758","identifier":"CHEBI:37565","identifierLink":"http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:37565","name":"gtp(4-)","description":"GTP(4-)","stochiometry":"minValue: 1, maxValue: 1","bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"small molecule","interactorTypeMI":"MI:0328","interactorTypeDefinition":"Molecule not part of or directly encoded by the genome, encompasses any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer, etc., identifiable as a separately distinguishable entity.","linkedFeatures":[{"featureAc":"EBI-61184778","participantId":"P01116","name":"GTP binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["59-60","29-35","10-18","116-119"],"linkedFeatures":["EBI-61184759"],"crossReferences":[]}],"otherFeatures":[]},{"interactorAC":"EBI-61184764","identifier":"P62136","identifierLink":"https://www.uniprot.org/uniprotkb/P62136/entry","name":"PPP1CA","description":"Serine/threonine-protein phosphatase PP1-alpha catalytic subunit","stochiometry":"minValue: 1, maxValue: 1","bioRole":"enzyme","bioRoleMI":"MI:0501","bioRoleDefinition":"Molecule catalyzing a modification on its interacting partner.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-61184756","participantId":"CHEBI:29035","name":"PPP1CA binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["?-?"],"linkedFeatures":["EBI-61184767"],"crossReferences":[]},{"featureAc":"EBI-61184787","participantId":"Q9UQ13","name":"PPP1CA binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["1-582"],"linkedFeatures":["EBI-61184775"],"crossReferences":[]},{"featureAc":"EBI-61184762","participantId":"CHEBI:29035","name":"PPP1CA binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["?-?"],"linkedFeatures":["EBI-61184771"],"crossReferences":[]},{"featureAc":"EBI-61184782","participantId":"P01116","name":"PPP1CA binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["2-186"],"linkedFeatures":["EBI-61184765"],"crossReferences":[]}],"otherFeatures":[]},{"interactorAC":"EBI-61184777","identifier":"P01116","identifierLink":"https://www.uniprot.org/uniprotkb/P01116/entry","name":"KRAS","description":"GTPase KRas","stochiometry":"minValue: 1, maxValue: 1","bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-61184759","participantId":"CHEBI:37565","name":"KRAS binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["?-?"],"linkedFeatures":["EBI-61184778"],"crossReferences":[]},{"featureAc":"EBI-61184789","participantId":"Q9UQ13","name":"KRAS binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["1-582"],"linkedFeatures":["EBI-61184784"],"crossReferences":[]},{"featureAc":"EBI-61184765","participantId":"P62136","name":"KRAS binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["2-330"],"linkedFeatures":["EBI-61184782"],"crossReferences":[]}],"otherFeatures":[]},{"interactorAC":"EBI-61184786","identifier":"Q9UQ13","identifierLink":"https://www.uniprot.org/uniprotkb/Q9UQ13/entry","name":"SHOC2","description":"Leucine-rich repeat protein SHOC-2","stochiometry":"minValue: 1, maxValue: 1","bioRole":"unspecified role","bioRoleMI":"MI:0499","bioRoleDefinition":"Role not specified or not applicable to the data.","interactorType":"protein","interactorTypeMI":"MI:0326","interactorTypeDefinition":"A linear polymer of amino acids joined by peptide bonds in a specific sequence.","linkedFeatures":[{"featureAc":"EBI-61184784","participantId":"P01116","name":"SHOC2 binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["2-186"],"linkedFeatures":["EBI-61184789"],"crossReferences":[]},{"featureAc":"EBI-61184775","participantId":"P62136","name":"SHOC2 binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. This may or may not be a region of the molecule in direct contact with the interacting partner.","featureTypeUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0117","featureRole":null,"featureRoleMI":null,"featureRoleDefinition":null,"featureRoleUrl":null,"ranges":["2-330"],"linkedFeatures":["EBI-61184787"],"crossReferences":[]}],"otherFeatures":[]}],"crossReferences":[{"database":"pubmed","qualifier":"additional information","identifier":"35830882","description":null,"searchURL":"http://europepmc.org/abstract/MED/35830882","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"efo","qualifier":"additional information","identifier":"MONDO:0004992","description":null,"searchURL":"http://www.ebi.ac.uk/ols/ontologies/efo/terms?obo_id=MONDO:0004992","dbMI":"MI:1337","qualifierMI":"MI:0361","dbdefinition":"The Experimental Factor Ontology provides a systematic description of many experimental variables, combining parts of several biological ontologies to additional new terms.","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"35768504","description":null,"searchURL":"http://europepmc.org/abstract/MED/35768504","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"35831509","description":null,"searchURL":"http://europepmc.org/abstract/MED/35831509","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"36175670","description":null,"searchURL":"http://europepmc.org/abstract/MED/36175670","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"gene ontology","qualifier":"molecular function","identifier":"GO:0004722","description":"protein serine/threonine phosphatase activity","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0004722","dbMI":"MI:0448","qualifierMI":"MI:0355","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'molecular function' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0355"},{"database":"evidence ontology","qualifier":null,"identifier":"ECO:0000353","description":null,"searchURL":"http://www.ebi.ac.uk/ols/ontologies/ECO/terms?obo_id=ECO:0000353","dbMI":"MI:1331","qualifierMI":null,"dbdefinition":"The Evidence Ontology (ECO) describes types of scientific evidence within the realm of biological research that can arise from laboratory experiments, computational methods, manual literature curation, and other means.","qualifierDefinition":null,"qualifierUrl":null},{"database":"gene ontology","qualifier":"biological process","identifier":"GO:0046579","description":"positive regulation of Ras protein signal transduction","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0046579","dbMI":"MI:0448","qualifierMI":"MI:0359","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular process' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0359"},{"database":"gene ontology","qualifier":"cellular component","identifier":"GO:0000164","description":"protein phosphatase type 1 complex","searchURL":"https://www.ebi.ac.uk/QuickGO/term/GO:0000164","dbMI":"MI:0448","qualifierMI":"MI:0354","dbdefinition":"The objective of Gene Ontology (GO) is to provide controlled vocabularies for the description of the molecular function, biological process and cellular component of gene products.","qualifierDefinition":"Cross reference pointing to a Gene Ontology -'cellular component' term.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0354"},{"database":"intact","qualifier":"Experimental evidence that interaction occurs","identifier":"EBI-61184315","description":null,"searchURL":"http://www.ebi.ac.uk/intact/query/EBI-61184315","dbMI":"MI:0469","qualifierMI":null,"dbdefinition":"INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.","qualifierDefinition":null,"qualifierUrl":null},{"database":"efo","qualifier":"additional information","identifier":"MONDO:0005575","description":null,"searchURL":"http://www.ebi.ac.uk/ols/ontologies/efo/terms?obo_id=MONDO:0005575","dbMI":"MI:1337","qualifierMI":"MI:0361","dbdefinition":"The Experimental Factor Ontology provides a systematic description of many experimental variables, combining parts of several biological ontologies to additional new terms.","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"pubmed","qualifier":"additional information","identifier":"28162770","description":null,"searchURL":"http://europepmc.org/abstract/MED/28162770","dbMI":"MI:0446","qualifierMI":"MI:0361","dbdefinition":"PubMed is designed to provide access to citations from biomedical literature. The data can be found at both NCBI PubMed and Europe PubMed Central. \n\nhttp://europepmc.org","qualifierDefinition":"Related object within the same database or pointing to an external database.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0361"},{"database":"complex portal","qualifier":"complex-primary","identifier":"CPX-26355","description":null,"searchURL":"http://www.ebi.ac.uk/complexportal/complex/CPX-26355","dbMI":"MI:2279","qualifierMI":"MI:2282","dbdefinition":"The Complex Portal is a manually curated, encyclopaedic resource of macromolecular complexes from a number of key model organisms, entered into the IntAct molecular interaction database . Data includes protein-only complexes as well as protein-small molecule and protein-nucleic acid complexes. All complexes are derived from physical molecular interaction evidences extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background. All complexes are tagged with Evidence and Conclusion Ontology codes to indicate the type of evidence available for each entry.","qualifierDefinition":"Complex object unique primary identifier that is assigned to a complex in the Complex Portal.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:2282"},{"database":"rhea","qualifier":"identical object in an external resource","identifier":"RHEA:47004","description":null,"searchURL":"https://www.rhea-db.org/reaction?id=RHEA:47004","dbMI":"MI:2344","qualifierMI":"MI:0356","dbdefinition":"Rhea is an expert curated resource of biochemical reactions designed for the annotation of enzymes and genome-scale metabolic networks and models. Rhea uses the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to precisely describe reactions participants and their chemical structures. All reactions are balanced for mass and charge and are linked to source literature, metabolic resources and other functional vocabularies such as the enzyme classification of the NC-IUBMB.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"rhea","qualifier":"identical object in an external resource","identifier":"RHEA:20629","description":null,"searchURL":"https://www.rhea-db.org/reaction?id=RHEA:20629","dbMI":"MI:2344","qualifierMI":"MI:0356","dbdefinition":"Rhea is an expert curated resource of biochemical reactions designed for the annotation of enzymes and genome-scale metabolic networks and models. Rhea uses the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to precisely describe reactions participants and their chemical structures. All reactions are balanced for mass and charge and are linked to source literature, metabolic resources and other functional vocabularies such as the enzyme classification of the NC-IUBMB.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"rhea","qualifier":"identical object in an external resource","identifier":"RHEA:19669","description":null,"searchURL":"https://www.rhea-db.org/reaction?id=RHEA:19669","dbMI":"MI:2344","qualifierMI":"MI:0356","dbdefinition":"Rhea is an expert curated resource of biochemical reactions designed for the annotation of enzymes and genome-scale metabolic networks and models. Rhea uses the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to precisely describe reactions participants and their chemical structures. All reactions are balanced for mass and charge and are linked to source literature, metabolic resources and other functional vocabularies such as the enzyme classification of the NC-IUBMB.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"intenz","qualifier":"identical object in an external resource","identifier":"3.6.5.2","description":null,"searchURL":"http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.5.2&t=exact&fields=ec","dbMI":"MI:0585","qualifierMI":"MI:0356","dbdefinition":"IntEnz is the name for the Integrated relational Enzyme database and is the official version of the Enzyme Nomenclature. The Enzyme Nomenclature comprises recommendations of the Nomenclature Committee of the International Union of Bio chemistry and Molecular Biology (NC-IUBMB) on the nomenclature and classification of enzyme-catalysed reactions. IntEnz is supported by NC-IUBMB and contains enzyme data curated and approved by this committee. The database IntEnz is available at.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"},{"database":"intenz","qualifier":"identical object in an external resource","identifier":"3.1.3.16","description":null,"searchURL":"http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.16&t=exact&fields=ec","dbMI":"MI:0585","qualifierMI":"MI:0356","dbdefinition":"IntEnz is the name for the Integrated relational Enzyme database and is the official version of the Enzyme Nomenclature. The Enzyme Nomenclature comprises recommendations of the Nomenclature Committee of the International Union of Bio chemistry and Molecular Biology (NC-IUBMB) on the nomenclature and classification of enzyme-catalysed reactions. IntEnz is supported by NC-IUBMB and contains enzyme data curated and approved by this committee. The database IntEnz is available at.","qualifierDefinition":"Reference to the corresponding object in another database. Correspondence may be complete or partial.","qualifierUrl":"http://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI:0356"}],"institution":"IntAct","institutionURL":"http://www.ebi.ac.uk/intact","agonists":[],"antagonists":[],"comments":[],"predictedComplex":false,"evidenceType":{"identifier":"ECO:0000353","description":"physical interaction evidence","searchURL":"http://www.ebi.ac.uk/ols/ontologies/ECO/terms?obo_id=ECO:0000353","confidenceScore":5},"releaseDates":["2025-03-28"]}