{"systematicName":"2xRNR1:RNR2:RNR4","synonyms":["Ribonucleotide-diphosphate reductase","Ribonucleotide reductase","RNR","2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase","Ribonucleoside 5'-diphosphate reductase","Ribonucleoside diphosphate reductase","Ribonucleotide diphosphate reductase"],"functions":["Catalyzes the reduction of ribonucleotides to the corresponding deoxyribonucleotides, an essential step in the de novo synthesis of monomeric precursors for DNA replication and repair. The catalytically active form is an alpha2beta2 tetramer. The homodimeric alpha subunit, called R1, houses the active site, composed of redox-active disulfides, and binding sites for allosteric effectors, ribonucleoside diphosphates. The beta subunit, called R2, contains a di-iron cluster that in its reduced state reacts with dioxygen to form a stable tyrosyl radical (Y*) and a di-iron(III) cluster. This essential Y* is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site, that initiates ribonucleotide reduction. The enzyme is allosterically controlled by relative levels of dNTPs. This variant is found in all cell states, a related variant (CPX-1103) is only found in damaged or growth-arrested cells.  the small subunit, RNR2-RNR4, is nuclear while the large subunit, RNR1, is cytoplasmic. In response to S-phase or DNA-damage, RNR2-RNR4 enters the cytoplasm to bind RNR1."],"properties":["Sedimention coefficient = 9.7 S"],"ac":"EBI-1396664","complexAc":"CPX-1102","name":"Ribonucleoside-diphosphate reductase variant 1","species":"Saccharomyces cerevisiae; 559292","ligands":[],"complexAssemblies":["Heterotetramer"],"diseases":[],"participants":[{"interactorAC":"EBI-22053344","identifier":"CHEBI:24875","identifierLink":"http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:24875","name":"iron cation","description":"iron cation","stochiometry":"minValue: 2, maxValue: 2","bioRole":"cofactor","bioRoleMI":"MI:0682","bioRoleDefinition":"A cofactor is a small molecule required for the catalysis of an enzyme.","interactorType":"small molecule","interactorTypeMI":"MI:0328","interactorTypeDefinition":"Molecule not part of or directly encoded by the genome, encompasses any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer, etc., identifiable as a separately distinguishable entity.","linkedFeatures":[{"featureAc":"EBI-22053345","participantId":"P09938","name":"iron binding region","featureType":"binding region","featureTypeMI":"MI:0117","featureTypeDefinition":"A region of a molecule or a component of a complex identified as being involved in an interaction. 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