126.96.36.199 - Serine--tRNA ligase
- Seryl-transfer RNA synthetase.
- Seryl-tRNA synthetase.
- Seryl-transfer ribonucleic acid synthetase.
- Serine translase.
- Seryl-transfer ribonucleate synthetase.
ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)
There are no Cofactors for this Enzyme
Serine-tRNA ligase (EC:188.8.131.52) exists as monomer and belongs to the aminoacyl-tRNA synthetase class IIa. It catalyses the attachment of serine to tRNA (Ser). It is also able to aminoacylate tRNA (Sec) with serine, to form the misacylated tRNA L-seryl-tRNA (Sec), which will be further converted into selenocysteinyl-tRNA (Sec).
This enzyme catalyzes two successive transfer reactions. Firstly, it transfers the adenylate from ATP (the first substrate) to the carboxylate of the second substrate, serine, resulting in the formation of seryl-adenylate (intermediate) and the release of the inorganic pyrophosphate. Secondly, it transfers the acyl group from the intermediate to the 3'-OH of tRNA(Ser). The ATP is found in an unusual bent conformation, stabilised by interactions with conserved arginines and three manganese ions.
|AA||Uniprot||Uniprot Resid||PDB||PDB Resid|
There are no kinetic parameters information for this Enzyme
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