Cofactors

Iron-sulfur.

Reaction Mechanism

There are no Reaction Mechanism for this Enzyme

Reaction Parameters

• Kinetic Parameters

  Organism	KM Value [mM]	Substrate	Comment
  Saccharomyces cerevisiae	0.0216	dimethylcitraconate
  Neurospora crassa	0.078	alpha-hydroxy-beta-carboxyisocaproate
  Candida maltosa	0.75	beta-carboxy-beta-hydroxyisocaproate

• Temperature

  Organism	Temperature Range	Comment
  Mycobacterium tuberculosis	15 - 95

• pH

  Organism	pH Range	Comment
  Mycobacterium tuberculosis	4 - 9.5
  Salmonella enterica subsp. enterica serovar Typhimurium	6 - 8	at pH 6.0, 20% of optimum activity, activity varies only about 20% between pH 7.0 and 8.0
  Neurospora crassa	6 - 8	at pH 6.0, 20% of optimum activity, activity varies only about 20% between pH 7.0 and 8.0
  Neurospora sp.	6 - 8	at pH 6.0, 20% of optimum activity, activity varies only about 20% between pH 7.0 and 8.0
  Salmonella sp.	6 - 8	at pH 6.0, 20% of optimum activity, activity varies only about 20% between pH 7.0 and 8.0

Associated Proteins

Citations

• Sustainable production of photosynthetic isobutanol and 3-methyl-1-butanol in the cyanobacterium Synechocystis sp. PCC 6803.
• Polyethylene Degradation by a Rhodococcous Strain Isolated from Naturally Weathered Plastic Waste Enrichment.
• Proteome and Interactome Linked to Metabolism, Genetic Information Processing, and Abiotic Stress in Gametophytes of Two Woodferns.
• Characterization and Correlation of Microbiota and Higher Alcohols Based on Metagenomic and Metabolite Profiling during Rice-Flavor Baijiu Fermentation.
• Integrated Metabolome and Transcriptome Analyses Reveal Amino Acid Biosynthesis Mechanisms during the Physiological Maturity of Grains in Yunnan Hulled Wheat (Triticum aestivum ssp. yunnanense King).
• Antibacterial Components and Modes of the Methanol-Phase Extract from Commelina communis Linn.
• A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway.
• Stochastic Processes Drive the Assembly and Metabolite Profiles of Keystone Taxa during Chinese Strong-Flavor Baijiu Fermentation.
• Global regulatory factor VeA upregulates the production of antitumor substances in endophytic Fusarium solani.
• Low dissolved oxygen supply functions as a global regulator of the growth and metabolism of Aurantiochytrium sp. PKU#Mn16 in the early stages of docosahexaenoic acid fermentation.
• Global regulatory factor FsveA up-regulate the production of antitumor substance in endophytic Fusarium solani