126.96.36.199 - Enoyl-CoA hydratase
- Unsaturated acyl-CoA hydratase.
- Enoyl hydrase.
(3S)-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O
There are no Cofactors for this Enzyme
Enoyl-CoA hydratase catalyses the hydration of trans-2-enoyl-CoA thiolesters to the corresponding 3(S)-hydroxyacyl-CoA compounds, the second step in the fatty acid beta-oxidation pathway. The enzymes degrade fatty acids of variable tail length from C4 up to at least C16, but the rate of the reaction decreases with increasing tail length. Enoyl-CoA hydratase is a member of the corotonase superfamily of enzymes.
Despite the thermodynamic preference for the aromatic conjugated unsaturated substrate, the enzyme has been shown to catalyse the dehydration of 3-hydroxy-3-phenylpropanoyl-CoA to cinnamoyl-CoA.
|AA||Uniprot||Uniprot Resid||PDB||PDB Resid|
intermediate formation, intermediate terminated, bimolecular nucleophilic addition, proton transfer, native state of enzyme regenerated, overall reactant used, overall product formed
- Biosynthesis of Vanillin by Rational Design of Enoyl-CoA Hydratase/Lyase.
- Boosting Lipid Production in the Diatom Phaeodactylum tricornutum by Knockdown of the Enoyl CoA Hydratase Using CRISPR Interference
- Enoyl-CoA hydratase/3-hydroxyacyl CoA dehydrogenase is essential for the production of DHA in zebrafish.
- Neuropathological Findings in Short-Chain enoyl-CoA Hydratase 1 Deficiency (ECHS1D): Case Report and Differential Diagnosis.
- Clinical improvements after treatment with a low-valine and low-fat diet in a pediatric patient with enoyl-CoA hydratase, short chain 1 (ECHS1) deficiency.
- Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency.
- Loss of mitochondrial fatty acid β-oxidation protein short-chain Enoyl-CoA hydratase disrupts oxidative phosphorylation protein complex stability and function.
- Developing efficient vanillin biosynthesis system by regulating feruloyl-CoA synthetase and enoyl-CoA hydratase enzymes.
- Characterization of an (R)-specific enoyl-CoA hydratase from Streptomyces sp. strain CFMR 7: A metabolic tool for enhancing the production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate).
- Crystal structure of enoyl-CoA hydratase from Thermus thermophilus HB8.
- Exploring triheptanoin as treatment for short chain enoyl CoA hydratase deficiency.