126.96.36.199 - Anthranilate synthase
There are no alternative names for this Enzyme
horismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate
There are no Cofactors for this Enzyme
The enzyme from Serratia marcescens is a heterotetramer of anthranilate synthase (TrpE) and glutamine amidotransferase (TrpG) subunits both of which are required for function.
|AA||Uniprot||Uniprot Resid||PDB||PDB Resid|
overall reactant used, proton transfer, unimolecular elimination by the conjugate base, overall product formed, enzyme-substrate complex formation, bimolecular nucleophilic addition, intermediate formation, intermediate terminated, native state of enzyme regenerated, bimolecular elimination, deamination, intermediate collapse, enzyme-substrate complex cleavage
There are no kinetic parameters information for this Enzyme
- In silico prediction of mutation sites for anthranilate synthase from Serratia marcesens to deregulate tryptophan feedback inhibition.
- Photoswitching of Feedback Inhibition by Tryptophan in Anthranilate Synthase.
- Structure of subunit I of the anthranilate synthase complex of Mycolicibacterium smegmatis.
- Effect of elicitors on the production of pyrroloquinazoline alkaloids by stimulating anthranilate synthase activity in Adhatoda vasica Nees cell cultures.
- The fused anthranilate synthase from Streptomyces venezuelae functions as a monomer.
- Uncoupling of an ammonia channel as a mechanism of allosteric inhibition in anthranilate synthase of Serratia marcescens: dynamic and graph theoretical analysis.
- Conversion of anthranilate synthase into isochorismate synthase: implications for the evolution of chorismate-utilizing enzymes.
- Still stable after 11 years: A Catharanthus roseus Hairy root line maintains inducible expression of anthranilate synthase.
- Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex.
- Microbial synthesis of the plant natural product precursor p-coumaric acid with Corynebacterium glutamicum.
- Examining the transcriptional response of overexpressing anthranilate synthase in the hairy roots of an important medicinal plant Catharanthus roseus by RNA-seq.