Cofactors

Pyridoxal 5'-phosphate.

Reaction Mechanism

There are no Reaction Mechanism for this Enzyme

Reaction Parameters

There are no kinetic parameters information for this Enzyme

Associated Proteins

Citations

• Substrate access path-guided engineering of L-threonine aldolase for improving diastereoselectivity.
• Mutability-Landscape-Guided Engineering of l-Threonine Aldolase Revealing the Prelog Rule in Mediating Diastereoselectivity of C-C Bond Formation.
• Discovery and Engineering of the l-Threonine Aldolase fromNeptunomonas Marinefor Efficient Synthesis of β-Hydroxy-α-Amino Acids via C–C Formation
• Application of l-Threonine Aldolase to on-DNA Reactions.
• Comprehensive screening strategy coupled with structure-guided engineering of l-threonine aldolase from Pseudomonas putida for enhanced catalytic efficiency towards l-threo-4-methylsulfonylphenylserine.
• Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase.
• Improving the C_β Stereoselectivity of l-Threonine Aldolase for the Synthesis of l-threo-4-Methylsulfonylphenylserine by Modulating the Substrate-Binding Pocket To Control the Orientation of the Substrate Entrance.
• Engineering of l-threonine aldolase for the preparation of 4-(methylsulfonyl)phenylserine, an important intermediate for the synthesis of florfenicol and thiamphenicol.
• Construction of a Highly Diastereoselective Aldol Reaction System with l-Threonine Aldolase by Computer-Assisted Rational Molecular Modification and Medium Engineering.
• Comparison of L-Threonine Aldolase Variants in the Aldol and Retro-Aldol Reactions.
• Bioinformatic analysis of the fold type I PLP-dependent enzymes reveals determinants of reaction specificity in l-threonine aldolase from Aeromonas jandaei.