184.108.40.206 - Tartronate-semialdehyde synthase
- Tartronate semialdehyde carboxylase.
- Glyoxylate carboligase.
2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO2
|AA||Uniprot||Uniprot Resid||PDB||PDB Resid|
overall reactant used, proton transfer, overall product formed, intramolecular elimination, bimolecular nucleophilic addition, native state of cofactor regenerated, intermediate formation, native state of enzyme regenerated, inferred reaction step, cofactor used
The glyoxylate-TDP adduct undergoes decarboxylation with concomitant bond rearrangement on the thiazole ring. The aliphatic region around the cofactor encourages decarboxylation through polar, non-polar interactions, which act to increase the ground state energy of the intermediate towards that of the transition state [PMID:18176558, PMID:15501823, PMID:15709735]
There are no kinetic parameters information for this Enzyme
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