22.214.171.124 - CDP-diacylglycerol diphosphatase
- CDP-diacylglycerol pyrophosphatase.
- CDP-diacylglycerol phosphatidylhydrolase.
CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)
There are no Cofactors for this Enzyme
5-aminoimidazole ribotide (AIR) is a branch point metabolite in the biosynthetic pathways of purines and thiamin. Although AIR cannot be efficiently taken up by most bacteria, 5-aminoimidazole riboside (AIRs) can. Aminoimidazole riboside kinase catalyses the phosphorylation of AIRs into AIR to feed into purine and thiamin biosynthesis pathways.
The mechanism proposed is mainly by homology to other ribokinases, such as human adenosine kinase. Asp 252 is a general base and deprotonates the 5' hydroxyl group of the ribose. The deprotonated hydroxyl attacks the gamma-phosphate of ATP in an inline displacement mechanism. The backbone amides of Gly 249, Ala 250, Gly 251 and Asp 252 act as an anion hole to stabilise negative charge build-up in the pentacovalent transition state. The products are AIR and ADP.
|AA||Uniprot||Uniprot Resid||PDB||PDB Resid|
There are no kinetic parameters information for this Enzyme
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