Cofactors

There are no Cofactors for this Enzyme

Reaction Mechanism

CDP-diacylglycerol diphosphatase By Reference

5-aminoimidazole ribotide (AIR) is a branch point metabolite in the biosynthetic pathways of purines and thiamin. Although AIR cannot be efficiently taken up by most bacteria, 5-aminoimidazole riboside (AIRs) can. Aminoimidazole riboside kinase catalyses the phosphorylation of AIRs into AIR to feed into purine and thiamin biosynthesis pathways.




The mechanism proposed is mainly by homology to other ribokinases, such as human adenosine kinase. Asp 252 is a general base and deprotonates the 5' hydroxyl group of the ribose. The deprotonated hydroxyl attacks the gamma-phosphate of ATP in an inline displacement mechanism. The backbone amides of Gly 249, Ala 250, Gly 251 and Asp 252 act as an anion hole to stabilise negative charge build-up in the pentacovalent transition state. The products are AIR and ADP.

Catalytic Residues

AA	Uniprot	Uniprot Resid	PDB	PDB Resid
Asp	Q8ZKR2	252	1tz3	272
Gly	Q8ZKR2	249	1tz3	269
Ala	Q8ZKR2	250	1tz3	270
Gly	Q8ZKR2	251	1tz3	271
View Reaction Mechanisms in M-CSA

Reaction Parameters

There are no kinetic parameters information for this Enzyme

Associated Proteins

Citations

• What can be lost? Genomic perspective on the lipid metabolism of Mucoromycota.
• Transcriptome and metabonomics combined analysis revealed the energy supply mechanism involved in fruiting body initiation in Chinese cordyceps.
• Metabolic Engineering for Efficient Production of Z,Z-Farnesol in E. coli.
• De Novo Transcriptome of the Flagellate Isochrysis galbana Identifies Genes Involved in the Metabolism of Antiproliferative Metabolites.
• A new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress
• Comparative genomics analysis of statistically significant genomic islands of Helicobacter pylori strains for better understanding the disease prognosis.
• Complete Genomic Analysis of VRE From a Cattle Feedlot: Focus on 2 Antibiotic Resistance.
• Insights Into the Evolution of Staphylococcus aureus Daptomycin Resistance From an in vitro Bioreactor Model.
• Stable isotope informed genome-resolved metagenomics reveals that Saccharibacteria utilize microbially-processed plant-derived carbon.
• Transcriptional profiling reveals differentially expressed genes involved in lipid biosynthesis during cacao seed development.
• iTRAQ-Based Proteomic Analysis of Sublethally Injured Escherichia coli O157:H7 Cells Induced by High Pressure Carbon Dioxide.