Cofactors

There are no Cofactors for this Enzyme

Reaction Mechanism

There are no Reaction Mechanism for this Enzyme

Reaction Parameters

• Kinetic Parameters

  Organism	KM Value [mM]	Substrate	Comment
  Methanothermobacter thermautotrophicus	0.00075	1-(5-phosphoribosyl)-AMP	pH 8.0, 65°C, recombinant enzyme with bound Cd2+
  Methanococcus vannielii	0.009	1-(5-phosphoribosyl)-AMP

• Temperature

  There are no reaction parameters information for this Enzyme.

• pH

  Organism	pH Range	Comment
  Methanothermobacter thermautotrophicus	6.5 - 9	pH profile, recombinant enzyme

Associated Proteins

Citations

• Catalytic Cycle of the Bifunctional Enzyme Phosphoribosyl-ATP Pyrophosphohydrolase/Phosphoribosyl-AMP Cyclohydrolase.
• Identification of Phosphoribosyl-AMP cyclohydrolase, as drug target and its inhibitors in Brucella melitensis bv. 1 16M using metabolic pathway analysis.
• Role of riboflavin biosynthesis gene duplication and transporter in Aeromonas salmonicida virulence in marine teleost fish.
• Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI.
• Metabolic Engineering of Bacillus subtilis for Riboflavin Production: A Review.
• Exploitation of a Type 1 Toxin-Antitoxin System as an Inducible Counter-Selective Marker for Genome Editing in the Acetogen Eubacterium limosum.
• Purine Nucleotide Alterations in Tumoral Cell Lines Maintained with Physiological Levels of Folic Acid.
• Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling.
• AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans.
• Inborn Errors of Purine Salvage and Catabolism.
• Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data.