188.8.131.52 - Phosphoribosyl-AMP cyclohydrolase
There are no alternative names for this Enzyme
1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
There are no Cofactors for this Enzyme
There are no Reaction Mechanism for this Enzyme
Organism KM Value [mM] Substrate Comment Methanothermobacter thermautotrophicus 0.00075 1-(5-phosphoribosyl)-AMP pH 8.0, 65°C, recombinant enzyme with bound Cd2+ Methanococcus vannielii 0.009 1-(5-phosphoribosyl)-AMP
There are no reaction parameters information for this Enzyme.
Organism pH Range Comment Methanothermobacter thermautotrophicus 6.5 - 9 pH profile, recombinant enzyme
- Catalytic Cycle of the Bifunctional Enzyme Phosphoribosyl-ATP Pyrophosphohydrolase/Phosphoribosyl-AMP Cyclohydrolase.
- Identification of Phosphoribosyl-AMP cyclohydrolase, as drug target and its inhibitors in Brucella melitensis bv. 1 16M using metabolic pathway analysis.
- Role of riboflavin biosynthesis gene duplication and transporter in Aeromonas salmonicida virulence in marine teleost fish.
- Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI.
- Metabolic Engineering of Bacillus subtilis for Riboflavin Production: A Review.
- Exploitation of a Type 1 Toxin-Antitoxin System as an Inducible Counter-Selective Marker for Genome Editing in the Acetogen Eubacterium limosum.
- Purine Nucleotide Alterations in Tumoral Cell Lines Maintained with Physiological Levels of Folic Acid.
- Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling.
- AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans.
- Inborn Errors of Purine Salvage and Catabolism.
- Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data.