Enzyme - Agmatinase

Alternative Name(s)
  • Agmatine ureohydrolase.

Catalytic Activity

gmatine + H2O = putrescine + urea


There are no Cofactors for this Enzyme

Reaction Mechanism

There are no Reaction Mechanism for this Enzyme

Reaction Parameters

  • Kinetic Parameters
    Organism KM Value [mM] Substrate Comment
    Methanocaldococcus jannaschii 0.00069 agmatine pH 7.5, 70°C, mutant enzyme C71S
  • Temperature

    There are no reaction parameters information for this Enzyme.

  • pH
    Organism pH Range Comment
    Methanocaldococcus jannaschii 6.5 - 10 no activity is detected at pH 6.5 and the measured activity steadily increases to pH 10.0. Higher pH values are tested but the observation of activity is dependent on the buffer used and are not reported here. Agmatine shows no hydrolysis in the pH 10 and 11 buffers and assay conditions used
    Pyrococcus horikoshii 9.5 - 12.5 pH 9.5: about 50% of maximal activity, pH 12.5: about 85% of maximal activity

Associated Proteins

Protein name Organism
Agmatinase 1 Synechocystis sp. (strain PCC 6803 / Kazusa)
Agmatinase, mitochondrial Human
Putative agmatinase 2 Fission yeast
Putative agmatinase 1 Fission yeast
Agmatinase Escherichia coli (strain K12)