Enzyme
3.1.3.74 - Pyridoxal phosphatase
Alternative Name(s)
- Vitamin B(6) (pyridoxine) phosphatase.
- PNP phosphatase.
- Vitamin B6-phosphate phosphatase.
- Vitamin B6 (pyridoxine) phosphatase.
- PLP phosphatase.
- Vitamin B(6)-phosphate phosphatase.
Catalytic Activity
H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal
Cofactors
Mg(2+).
Reaction Mechanism
There are no Reaction Mechanism for this Enzyme
Reaction Parameters
-
Kinetic Parameters
Organism KM Value [mM] Substrate Comment Mus musculus 50 pyridoxal 5'-phosphate pH 7.4, 22°C -
Temperature
There are no reaction parameters information for this Enzyme.
-
pH
Organism pH Range Comment Sinorhizobium meliloti 5.5 - 9.5
Associated Proteins
Citations
- Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission.
- Ca2+ functions as a molecular switch that controls the mutually exclusive complex formation of pyridoxal phosphatase with CIB1 or calmodulin.
- Improved cognition, mild anxiety-like behavior and decreased motor performance in pyridoxal phosphatase-deficient mice.
- Fluorescent Turn-On Sensing of Zinc(II) and Alkaline Phosphatase Activity Using a Pyridoxal-5'-Phosphate Derived Schiff Base.
- Synthesis of hydrolysis-resistant pyridoxal 5'-phosphate analogs and their biochemical and X-ray crystallographic characterization with the pyridoxal phosphatase chronophin.
- Maintenance of cellular vitamin B6 levels and mitochondrial oxidative function depend on pyridoxal 5'-phosphate homeostasis protein.
- Hypophosphatasia: from birth to adulthood.
- Evaluation of vitamin B6 supplementation in Wilson's disease patients treated with D-penicillamine.
- Fluorescence Turn-on Detection of Alkaline Phosphatase Activity and Al3+ Using Vitamin B6 Cofactor Conjugated GSH Capped Mn-doped ZnS Quantum Dots.
- Effect of Asfotase Alfa in the Treatment of Hypophosphatasia- A Systematic Review.
- Musculoskeletal pain and muscular weakness as the main symptoms of adult hypophosphatasia in a Spanish cohort: clinical characterization and identification of a new ALPL gene variant.