Cofactors

There are no Cofactors for this Enzyme

Reaction Mechanism

There are no Reaction Mechanism for this Enzyme

Reaction Parameters

• Kinetic Parameters

  Organism	KM Value [mM]	Substrate	Comment
  Brugia malayi	0.11	trehalose 6-phosphate	mutant enzyme K334A, at pH 7.5 and 22°C
  Arthrobacter sp.	3.2	trehalose 6-phosphate	at pH 7.4 and 4°C

• Temperature

  Organism	Temperature Range	Comment
  Arthrobacter sp.	4 - 30	the enzyme exhibits full activity at 30°C, about 92% of the maximal activity at 20°C, about 85% of the maximal activity at 12°C, and still 75% of the maximal activity at 4°C
  Brugia malayi	25 - 60	activity range
  Phormia regina	30 - 58	30°C: about 45% of maximal activity, 58°C: about 85% of mmaximal activity
  Thermus thermophilus	40 - 90	recombinant enzyme, 45% of maximal activity at 90°C, about 15% at 40°C

• pH

  Organism	pH Range	Comment
  Oryza sativa Japonica Group	5.5 - 9
  Oryza sativa	5.5 - 9
  Arthrobacter sp.	5.5 - 7.5	the enzyme activity remains nearly constant from pH 5.0 to 7.0 in Mes/NaOH buffer and 7.0 to 7.5 in Tris/HCl buffer, whereas the enzyme shows almost no activity at pH 9.0 (Tris/HCl buffer) and half activity at pH 4.0 (acetate buffer)
  Phormia regina	5.8 - 8.2	pH 5.8: about 20% of maximal activity, pH 8.2: about 75% of maximal activity

Associated Proteins

Citations

• Genome-Wide Analysis and Expression Profiling of Trehalose-6-Phosphate Phosphatase (TPP) in Punica granatum in Response to Abscisic-Acid-Mediated Drought Stress.
• Synergistic antifungal activity of catechin and silver nanoparticles on Aspergillus niger isolated from coffee seeds
• The PP2A-like phosphatase Ppg1 mediates assembly of the Far complex to balance gluconeogenic outputs and adapt to glucose depletion
• Validamycin Inhibits the Synthesis and Metabolism of Trehalose and Chitin in the Oriental Fruit Fly, Bactrocera dorsalis (Hendel).
• Sucrose promotes branch-thorn occurrence of Lycium ruthenicum through dual effects of energy and signal.
• Genome- and transcriptome-wide identification of trehalose-6-phosphate phosphatases (TPP) gene family and their expression patterns under abiotic stress and exogenous trehalose in soybean
• Pathogenicity and virulence of Mycobacterium tuberculosis.
• ABF1 Positively Regulates Rice Chilling Tolerance via Inducing Trehalose Biosynthesis.
• Genome-Wide Identification and Analysis of Stress Response of Trehalose-6-Phosphate Synthase and Trehalose-6-Phosphate Phosphatase Genes in Quinoa.
• Two-way communication between cell cycle and metabolism in budding yeast: what do we know?
• Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogenCryptococcus neoformans: a target for novel antifungals