Enzyme

3.1.2.2 - Palmitoyl-CoA hydrolase

Alternative Name(s)
  • Long-chain fatty-acyl-CoA hydrolase.

Catalytic Activity

H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate

Cofactors

There are no Cofactors for this Enzyme

Reaction Mechanism

There are no Reaction Mechanism for this Enzyme

Reaction Parameters

  • Kinetic Parameters
    Organism KM Value [mM] Substrate Comment
    Mycolicibacterium smegmatis 0.077 CoA
    Sus scrofa 0.048 acetyl-CoA
    Mus musculus 0.0033 palmitoyl-CoA at pH 7.6 and 37°C
    Mycobacterium tuberculosis 0.01187 palmitoyl-CoA pH 7.5
    Buckleyzyma aurantiaca 0.023 palmitoyl-CoA pH 8.0, 25°C
  • Temperature

    There are no reaction parameters information for this Enzyme.

  • pH
    Organism pH Range Comment
    Euglena gracilis 4.5 - 7 about 75% of maximal activity at pH 4.5 and about half-maximal activity at pH 7.0, dodecanoyl-CoA as substrate
    Buckleyzyma aurantiaca 5 - 10
    Columba sp. 6 - 8
    Rattus norvegicus 6 - 10
    Escherichia coli 7 - 8.5

Associated Proteins

Protein name Organism
Palmitoyl-CoA hydrolase Rat
Acyl-coenzyme A thioesterase 3 Mouse
Cytosolic acyl coenzyme A thioester hydrolase Human
Acyl-coenzyme A thioesterase 5 Mouse
Acyl-coenzyme A thioesterase 2, mitochondrial Human

Citations