184.108.40.206 - Ribose-phosphate diphosphokinase
- Phosphoribosyl diphosphate synthetase.
- Ribose-phosphate pyrophosphokinase.
- Phosphoribosyl pyrophosphate synthetase.
ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)
There are no Cofactors for this Enzyme
There are no Reaction Mechanism for this Enzyme
Organism KM Value [mM] Substrate Comment Thermus thermophilus 14 ATP pH 8.0, 75°C Mycobacterium tuberculosis 26 ATP in 50 mM Tris-HCl pH 8.0, at 25°C Mycolicibacterium smegmatis 1315 D-ribose 5-phosphate pH 7.5, 25°C Pyrobaculum calidifontis 5183 D-ribose 5-phosphate pH 10.5, 55°C, recombinant enzyme
Organism Temperature Range Comment Methanocaldococcus jannaschii 72 - 95 70% of maximal activity at 72°C and 95°C
Organism pH Range Comment Mycobacterium tuberculosis 4.5 - 9.5 the enzyme shows activity across a broad range of pH levels (4.5-9.5) and is only found to be inactive at high pH 10.5 Salmonella enterica subsp. enterica serovar Typhimurium 6 - 9.5 very low activity below and above Homo sapiens 6.5 - 9.3 At pH 6.5, about 25% and 50% of maximum activity for isoenzymes PRSI and PRSII, respectively. At pH 9.3, about 40% and 60% of maximum activity for isoenzymes PRSII and PRSI, respectively [Bacillus] caldolyticus 6.5 - 9.5 pH 6.5: about 25% of maximal activity, pH 9.5: about 80% of maximal activity Bacillus subtilis 7 - 9.5 at pH 7 and pH 9.5, about 35% and 85% of the maximal activity, respectively
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