Enzyme
2.7.1.74 - Deoxycytidine kinase
Alternative Name(s)
There are no alternative names for this Enzyme
Catalytic Activity
2'-deoxycytidine + a ribonucleoside 5'-triphosphate = a ribonucleoside 5'-diphosphate + dCMP + H(+)
Cofactors
There are no Cofactors for this Enzyme
Reaction Mechanism
There are no Reaction Mechanism for this Enzyme
Reaction Parameters
There are no kinetic parameters information for this Enzyme
Associated Proteins
Citations
- Targeting host deoxycytidine kinase attenuatesStaphylococcus aureusvirulence
- Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency.
- MYC/Glutamine Dependency Is a Therapeutic Vulnerability in Pancreatic Cancer with Deoxycytidine Kinase Inactivation-Induced Gemcitabine Resistance.
- Facile method for determination of deoxycytidine kinase activity in biological milieus
- Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis.
- Combination of azacytidine and curcumin is a potential alternative in decitabine-resistant colorectal cancer cells with attenuated deoxycytidine kinase.
- Drug resistance to nelarabine in leukemia cell lines might be caused by reduced expression of deoxycytidine kinase through epigenetic mechanisms.
- Deoxycytidine Kinase (DCK) Mutations in Human Acute Myeloid Leukemia Resistant to Cytarabine.
- Effect of dexamethasone on the antileukemic effect of cytarabine: role of deoxycytidine kinase.
- Different Susceptibility of T and B Cells to Cladribine Depends On Their Levels of Deoxycytidine Kinase Activity Linked to Activation Status.
- Human equilibrative nucleoside transporter-1 and deoxycytidine kinase can predict gemcitabine effectiveness in Egyptian patients with Hepatocellular carcinoma.