Enzyme

2.6.1.5 - Tyrosine transaminase

Alternative Name(s)
  • Tyrosine aminotransferase.
  • TyrAT.

Catalytic Activity

2-oxoglutarate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-glutamate

Cofactors

Pyridoxal 5'-phosphate.

Reaction Mechanism

There are no Reaction Mechanism for this Enzyme

Reaction Parameters

  • Kinetic Parameters
    Organism KM Value [mM] Substrate Comment
    Papaver somniferum 0.01 oxaloacetate pH 8.5, 30°C
    Arabidopsis thaliana 0.02 oxaloacetate isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C
    Prunella vulgaris 0.02 pyruvate with L-tyrosine as cosubstrate, at pH 8.0 and 30°C
    Petunia x hybrida 0.04 L-phenylalanine cosubstrate 2-oxoglutarate, pH 10.0, 30°C
    Mus musculus 0.33 2-Oxohexanoate pH 7.0, 38°C
  • Temperature
    Organism Temperature Range Comment
    Leishmania donovani 20 - 80 more than 90% activity between 20 and 70°C, about 70% activity at 80°C, about 20% activity at 90°C, no activity at 100°C
    Mus musculus 50 - 70 highest activity
    Entodinium caudatum 55 decrease in activity above
  • pH
    Organism pH Range Comment
    Leishmania donovani 4 - 9 more than 50% activity between pH 4.0 and 9.0
    Variovorax paradoxus 4 - 11.2 enzyme shows high activity over a broad pH range
    Entodinium caudatum 5 - 10.5
    Trichoderma viride 6 - 8
    Anchusa officinalis 8.8 - 9.4 L-tyrosine as substrate, isoenzyme TAT-3

Associated Proteins

Protein name Organism
L-tyrosine:2-oxoglutarate aminotransferase atrD Oyster rollrim mushroom
L-tyrosine:2-oxoglutarate aminotransferase amt1 Dry rot fungus
Tyrosine aminotransferase Human
Aromatic aminotransferase ISS1 Mouse-ear cress
Putative aminotransferase TAT2 isoform X1 Dove tree

Citations