Enzyme - 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acidsynthase

Alternative Name(s)
  • SEPHCHC synthase.

Catalytic Activity

2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2



Reaction Mechanism

There are no Reaction Mechanism for this Enzyme

Reaction Parameters

  • Kinetic Parameters
    Organism KM Value [mM] Substrate Comment
    Escherichia coli 0.016 2-oxoglutarate mutant enzyme R395K/R413K, at pH 7.0 and 21°C
    Bacillus subtilis 0.07 2-oxoglutarate mutant F490A, pH 7.8, 23°C
  • Temperature

    There are no reaction parameters information for this Enzyme.

  • pH

    There are no reaction parameters information for this Enzyme.

Associated Proteins

Protein name Organism
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase Escherichia coli (strain K12)
Protein PHYLLO, chloroplastic Mouse-ear cress
Putative 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase Bifidobacterium scardovii
2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2- oxoglutarate decarboxylase Shigella flexneri
Bifunctional 2-oxoglutarate decarboxylase and SHCHC synthase Aeromonas sp. 9A


There are no citations for this Enzyme