Enzyme
1.5.1.37 - FAD reductase (NADH)
Alternative Name(s)
- NADH-dependent FAD reductase.
Catalytic Activity
FADH2 + NAD(+) = FAD + 2 H(+) + NADH
Cofactors
There are no Cofactors for this Enzyme
Reaction Mechanism
There are no Reaction Mechanism for this Enzyme
Reaction Parameters
-
Kinetic Parameters
Organism KM Value [mM] Substrate Comment Paraburkholderia phenoliruptrix 72.5 NADH cosubstrate: FMN, pH 7.0, 24°C Pseudomonas putida 6700 FAD pH 7.5, 25°C -
Temperature
Organism Temperature Range Comment Paraburkholderia phenoliruptrix 23 - 45 23°C: 85% of maximal activity, 45°C: 70% of maximal activity -
pH
Organism pH Range Comment Paraburkholderia phenoliruptrix 5 - 7.6 pH 5.0 (sodium succinate buffer): 52% of maximal activity, pH 7.6: 75% of maximal activity Pseudomonas protegens Pf-5 6 - 8 pH 6.0: 73% of maximal activity, pH 8.0: 81% of maximal activity
Associated Proteins
Citations
- Structural and functional characterization of a mycobacterial methylenetetrahydrofolate reductase utilizing NADH as the exclusive cofactor.
- Natural mutations of human XDH promote the nitrite (NO2-)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?
- The flavohaemoprotein hmp maintains redox homeostasis in response to reactive oxygen and nitrogen species in Corynebacterium glutamicum.
- Crystal structure of FAD-independent methylene-tetrahydrofolate reductase from Mycobacterium hassiacum.
- Driving the conversion of phytosterol to 9α-hydroxy-4-androstene-3,17-dione in Mycolicibacterium neoaurum by engineering the supply and regeneration of flavin adenine dinucleotide.
- The N-terminal intrinsically disordered region of Ncb5or docks with the cytochrome b5 core to form a helical motif that is of ancient origin
- A redox-regulated, heterodimeric NADH:cinnamate reductase inVibrio ruber
- Molecular architecture and electron transfer pathway of the Stn family transhydrogenase.
- Involvement of a flavoprotein, acetohydroxyacid synthase, in growth and riboflavin production in riboflavin-overproducing Ashbya gossypii mutant.
- Saccharomyces cerevisiae NRE1 and IRC24 Encode Paralogous Benzil Oxidoreductases.
- Fluorescence microscopy imaging of mitochondrial metabolism in cancer cells.