Enzyme

1.4.3.22 - Diamine oxidase

Alternative Name(s)
  • Histamine deaminase.
  • CAO.
  • Amine oxidase.
  • Semicarbazide-sensitive amine oxidase.
  • SSAO.
  • Cu-containing amine oxidase.
  • Diamino oxhydrase.
  • Histaminase.
  • Amine oxidase (copper-containing).
  • Copper amine oxidase.

Catalytic Activity

H2O + histamine + O2 = H2O2 + imidazole-4-acetaldehyde + NH4(+)

Cofactors

There are no Cofactors for this Enzyme

Reaction Mechanism

There are no Reaction Mechanism for this Enzyme

Reaction Parameters

  • Kinetic Parameters
    Organism KM Value [mM] Substrate Comment
    Pisum sativum 2100 O2 determined with putrescine
  • Temperature
    Organism Temperature Range Comment
    Vicia faba 20 - 63 about 50% activity at 20°C and 63°C
  • pH
    Organism pH Range Comment
    Glycine max 5 - 10 pH 5 and pH 10: 50% activity
    Homo sapiens 6.2 - 8.2 pH 6.2: about 75% of maximal activity, pH 8.2: about 60% of maximal activity

Associated Proteins

Protein name Organism
Amiloride-sensitive amine oxidase [copper-containing] Human
Histamine oxidase Arthrobacter globiformis

Citations