126.96.36.199 - 2-oxoaldehyde dehydrogenase (NADP(+))
- Methylglyoxal dehydrogenase.
- Alpha-ketoaldehyde dehydrogenase.
A 2-oxoaldehyde + NADP(+) + H(2)O = a 2-oxo acid + NADPH.
There are no Cofactors for this Enzyme
There are no Reaction Mechanism for this Enzyme
Organism KM Value [mM] Substrate Comment Ovis aries 0.0045 NADP+ Capra hircus 0.04 NADP+ Rattus norvegicus 0.14 methylglyoxal
There are no reaction parameters information for this Enzyme.
Organism pH Range Comment Ovis aries 6.5 not active below Homo sapiens 8.5 - 10 very low activity at physiological pH Rattus norvegicus 9.3 activity falls abruptly above
Associated ProteinsThere are no Associated Proteins for this Enzyme
- The possible role of methylglyoxal metabolism in cancer.
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- Methylglyoxal and Its Adducts: Induction, Repair, and Association with Disease.
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- Protein posttranslational modification (PTM) by glycation: Role in lens aging and age-related cataractogenesis.
- Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation.
- From Glucose to Lactate and Transiting Intermediates Through Mitochondria, Bypassing Pyruvate Kinase: Considerations for Cells Exhibiting Dimeric PKM2 or Otherwise Inhibited Kinase Activity.
- The Taming of Nuclear Factor Erythroid-2-Related Factor-2 (Nrf2) Deglycation by Fructosamine-3-Kinase (FN3K)-Inhibitors-A Novel Strategy to Combat Cancers.
- Perturbation of human coronary artery endothelial cell redox state and NADPH generation by methylglyoxal.
- Glyoxal formation and its role in endogenous oxalate synthesis.
- Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12.