Cofactors

There are no Cofactors for this Enzyme

Reaction Mechanism

There are no Reaction Mechanism for this Enzyme

Reaction Parameters

• Kinetic Parameters

  Organism	KM Value [mM]	Substrate	Comment
  Ovis aries	0.0045	NADP+
  Capra hircus	0.04	NADP+
  Rattus norvegicus	0.14	methylglyoxal

• Temperature

  There are no reaction parameters information for this Enzyme.

• pH

  Organism	pH Range	Comment
  Ovis aries	6.5	not active below
  Homo sapiens	8.5 - 10	very low activity at physiological pH
  Rattus norvegicus	9.3	activity falls abruptly above

Associated Proteins

Citations

• The possible role of methylglyoxal metabolism in cancer.
• Aldehyde-Associated Mutagenesis─Current State of Knowledge.
• Methylglyoxal and Its Adducts: Induction, Repair, and Association with Disease.
• A proteomics approach to decipher a sticky CHO situation.
• Protein posttranslational modification (PTM) by glycation: Role in lens aging and age-related cataractogenesis.
• Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation.
• From Glucose to Lactate and Transiting Intermediates Through Mitochondria, Bypassing Pyruvate Kinase: Considerations for Cells Exhibiting Dimeric PKM2 or Otherwise Inhibited Kinase Activity.
• The Taming of Nuclear Factor Erythroid-2-Related Factor-2 (Nrf2) Deglycation by Fructosamine-3-Kinase (FN3K)-Inhibitors-A Novel Strategy to Combat Cancers.
• Perturbation of human coronary artery endothelial cell redox state and NADPH generation by methylglyoxal.
• Glyoxal formation and its role in endogenous oxalate synthesis.
• Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12.