184.108.40.206 - Glutathione peroxidase
There are no alternative names for this Enzyme
2 glutathione + H2O2 = glutathione disulfide + 2 H2O
Glutathione peroxidase (GSHPx) is an enzyme that catalyses the reduction of hydroxyperoxides by glutathione. Its main function is to protect against the damaging effect of endogenously formed hydroxyperoxides.
Reaction is initiated by the nucleophilic attack of selenocysteine on the hydroperoxide. On collision with a hydroperoxide, the active-site selenium is readily oxidised to a selenenic acid derivative, which thereafter must be reduced to terminate the catalytic cycle.
|AA||Uniprot||Uniprot Resid||PDB||PDB Resid|
There are no kinetic parameters information for this Enzyme
- Glutathione peroxidase 1 and 2 during preimplantation period of pregnancy in mouse.
- The presence of glutathione peroxidase 8 (GPx8) in rat male genital organs.
- Modulation of sarcopenia phenotypes by glutathione peroxidase 4 overexpression in mice.
- Selenoneine-inspired selenohydantoins with glutathione peroxidase-like activity.
- Synthesis and glutathione peroxidase (GPx)-like activity of selenocystine (SeC) bioconjugates of biotin and lipoic acid.
- Impact of malaria on glutathione peroxidase levels: a systematic review and meta-analysis.
- Selenium-dependent glutathione peroxidase 1 regulates transcription of elongase 3 in murine tissues.
- Angiotensin IV ameliorates doxorubicin-induced cardiotoxicity by increasing glutathione peroxidase 4 and alleviating ferroptosis.
- Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4).
- A Glutathione Peroxidase-Mimicking Nanozyme Precisely Alleviates Reactive Oxygen Species and Promotes Periodontal Bone Regeneration.
- Injectable hydrogel with selenium nanoparticles delivery for sustained glutathione peroxidase activation and enhanced osteoarthritis therapeutics.