Enzyme

1.11.1.9 - Glutathione peroxidase

Alternative Name(s)

There are no alternative names for this Enzyme

Catalytic Activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O

Cofactors

Se(2+).

Reaction Mechanism

    glutathione peroxidase By Reference

    Glutathione peroxidase (GSHPx) is an enzyme that catalyses the reduction of hydroxyperoxides by glutathione. Its main function is to protect against the damaging effect of endogenously formed hydroxyperoxides.

    Reaction is initiated by the nucleophilic attack of selenocysteine on the hydroperoxide. On collision with a hydroperoxide, the active-site selenium is readily oxidised to a selenenic acid derivative, which thereafter must be reduced to terminate the catalytic cycle.
    Catalytic Residues
    AA Uniprot Uniprot Resid PDB PDB Resid
    Sec P00435 52 1gp1 45
    Trp P00435 165 1gp1 158
    Gln P00435 87 1gp1 80

Reaction Parameters

There are no kinetic parameters information for this Enzyme

Associated Proteins

Protein name Organism
Probable glutathione peroxidase 2 Mouse-ear cress
Putative glutathione peroxidase 7, chloroplastic Mouse-ear cress
Probable glutathione peroxidase 3, mitochondrial Mouse-ear cress
Cuticular glutathione peroxidase Wuchereria bancrofti
Probable glutathione peroxidase 5 Mouse-ear cress

Citations