ID EU408779; SV 1; linear; genomic DNA; STD; PHG; 14398 BP. XX AC EU408779; XX DT 06-NOV-2008 (Rel. 97, Created) DT 07-OCT-2021 (Rel. 144, Last updated, Version 2) XX DE Bacillus phage AP50, complete genome. XX KW . XX OS Bacillus phage AP50 OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; OC Kalamavirales; Tectiviridae; Betatectivirus. XX RN [1] RP 1-14398 RX DOI; 10.1128/AEM.01124-08. RX PUBMED; 18791014. RA Sozhamannan S., McKinstry M., Lentz S.M., Jalasvuori M., McAfee F., RA Smith A., Dabbs J., Ackermann H.W., Bamford J.K., Mateczun A., Read T.D.; RT "Molecular characterization of a variant of Bacillus anthracis-specific RT phage AP50 with improved bacteriolytic activity"; RL Appl Environ Microbiol 74(21):6792-6796(2008). XX RN [2] RP 1-14398 RA Sozhamannan S., Lentz S.M., Jalasvuori M., Bamford J.K.H., Read T.D.; RT ; RL Submitted (16-JAN-2008) to the INSDC. RL Genomics, BDRD Annex, Naval Medical Research Center, 12300 Washington RL Avenue, Rockville, MD 20852, USA XX DR MD5; 89c7d9bcb2722321e389ac64ee1083d4. DR EuropePMC; PMC2576697; 18791014. DR EuropePMC; PMC2849253; 20118353. DR EuropePMC; PMC4068676; 24795369. DR EuropePMC; PMC5758571; 29311588. XX FH Key Location/Qualifiers FH FT source 1..14398 FT /organism="Bacillus phage AP50" FT /host="Bacillus anthracis" FT /mol_type="genomic DNA" FT /db_xref="taxon:2880538" FT CDS 378..563 FT /codon_start=1 FT /transl_table=11 FT /product="truncated MerR-like protein" FT /note="ORF1; DNA binding regulatory protein" FT /db_xref="GOA:B6RT33" FT /db_xref="InterPro:IPR009061" FT /db_xref="InterPro:IPR010093" FT /db_xref="InterPro:IPR041657" FT /db_xref="UniProtKB/TrEMBL:B6RT33" FT /protein_id="ACB54900.1" FT /translation="MLFYTVKEFAEMAKISEKTVTRYIKTGDLEAVKFGGQWRITETAV FT QSYIKNNSNIGGREND" FT CDS 556..1098 FT /codon_start=1 FT /transl_table=11 FT /product="ssDNA binding protein" FT /note="ORF2" FT /db_xref="InterPro:IPR035408" FT /db_xref="UniProtKB/TrEMBL:B6RT34" FT /protein_id="ACB54901.1" FT /translation="MTNKNEQLNNGAVTSYVDTDMLANGEQPMVITPEVNTNDIVTVDK FT VSPSIFEAQGGKDVFFSSIQTKDRKSAIKVYNAINSSENPLADHRGEVLHITDMVAHAI FT TLEDDVTKEDVDALRVVLVDKDGKAYHAISQGVVSSIQKIISIVGPAPWTDEPLEIVPV FT EVKTRKGFKTLTLQLQG" FT CDS 1169..1393 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF3" FT /db_xref="UniProtKB/TrEMBL:B6RT35" FT /protein_id="ACB54902.1" FT /translation="MDGIKEVVQVSIKTNERDIEFTSFAGLNQIKQSLDGDVSSVVLTD FT EELEMMLCVKQRDKLASFFQSVLERKNAV" FT CDS 1456..2157 FT /codon_start=1 FT /transl_table=11 FT /product="genome terminal protein" FT /note="ORF4" FT /db_xref="UniProtKB/TrEMBL:B6RT36" FT /protein_id="ACB54903.1" FT /translation="MANKRQRKKIVKKKQESFLSSVGYSKKQMKTISTTDRAKVVKKET FT YKKKKRDKYHQARSMGFGSKEANKMSSWSDSRFIKYIEEFNSYYMIVMYKDVTEETDSE FT ALHMIKNHTKRRSTSNLLRSIKGWLSVDKNQGYIGGYEIQVGKKDEIDFHLYAYKQRKY FT LQAYRGQGLQLKPLLNLLENMMVLLYMVEAKDQFVEDLCTNLRKLPYEQAHINANYIEE FT EFITDRSDLHF" FT CDS 2171..4366 FT /codon_start=1 FT /transl_table=11 FT /product="DNAP" FT /note="ORF5; DNA polymerase; DNA replication" FT /db_xref="GOA:B6RT37" FT /db_xref="InterPro:IPR004868" FT /db_xref="InterPro:IPR012337" FT /db_xref="InterPro:IPR023211" FT /db_xref="UniProtKB/TrEMBL:B6RT37" FT /protein_id="ACB54904.1" FT /translation="MSNKQKKERQKPAKLLTLDTETRGLTGNVFRVGLFDGTNYYKSNT FT FDEILDLFEQYKDYECHVYVHNLDFDLAKIATTLFKRDRVRFAKSIFINGNVVTLHSDS FT MILHDSLRLLPGSLEKLCKDFGLTDNAKKDLSEVIKEQGYAVYKKDGVTFDKKKSLGNY FT FENVPADDPTLNEYLEFDCRSLYEILTIVMDIANIGLETLVMCPTTASLAMRVYKEQYR FT EQYDKVATHFYMGEWGQFLEEHVRQSYYGGRTEVFTPHLPHGYHYDVNSLYPYVMKIAK FT FPVGYPNLLKDGQAATKWKHWKRRAIGGGVMWCRVDVPEDMYIPVLPKRDPSGKLLFPV FT GKLEGVWTLPELLEAEKNGCTIEAIYQMVYWEHMEPIFKEFVEHFEDLKKNSKGAKRTF FT AKLIQNSLYGKFGMNRVRVSLGDMEDRYDLHEKQIPYKEFKHDCNGLTLEFIQYISESK FT ASYIQPHIATYVTAYARILLFRGLKEQASKGVLGYCDTDSIAGTAKMPDEMIHDEDYGK FT WALEGELEEGIFLQPKFYAERYTNGKEVIKAKGIPREKMEELSFENYKEWLEIMKEGQQ FT ERIDIFEGYESRKKFSTTLKASEDFDTLREMKKSINLLLEQKRDIDYKGNVTRPHKRYD FT YGDKKDKIDYEDYKSREDKLNNMYDDVDDLKEQVDEIGYIKCMKQGDMYFEEYKHLTKS FT VKSKYFRRTGTPIDVWANESGWDVNELLEELRLMGVC" FT CDS 4368..4571 FT /codon_start=1 FT /transl_table=11 FT /product="LexA-like protein" FT /note="ORF6; repressor; transcriptional regulation" FT /db_xref="GOA:B6RT38" FT /db_xref="InterPro:IPR006199" FT /db_xref="InterPro:IPR036388" FT /db_xref="InterPro:IPR036390" FT /db_xref="UniProtKB/TrEMBL:B6RT38" FT /protein_id="ACB54905.1" FT /translation="MLTDREQEALACISGYMRQNGFAPSVREMAGLLFVSHKTAHRYMI FT QLETKGHIKRIHHRSRAIQLCV" FT CDS 4587..4724 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF7" FT /db_xref="UniProtKB/TrEMBL:B6RT39" FT /protein_id="ACB54906.1" FT /translation="MRDKVLDLIIELSKSTKQVVAKDFIINELYKIAKEDESKEKETSK" FT CDS 4725..4814 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF8" FT /db_xref="UniProtKB/TrEMBL:B6RT40" FT /protein_id="ACB54907.1" FT /translation="MLVFLFVQNDTFVTLQANICLGYTCHIKQ" FT CDS 4827..5060 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF9" FT /db_xref="UniProtKB/TrEMBL:B6RT41" FT /protein_id="ACB54908.1" FT /translation="MEGIDLSHVQCSLPPIPNPLTFEDLTEEQFKALLNVIHDFKFACR FT ESNLPLAFYYVLEKCTDPVVKQELIDAHRYGC" FT CDS 5073..5246 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF10" FT /db_xref="UniProtKB/TrEMBL:B6RT42" FT /protein_id="ACB54909.1" FT /translation="MFKTLSKLYRDLLHQNIDLHNENTKLRLQNARLQSKLATAEIDLY FT HFKNSIERMINK" FT CDS 5243..5587 FT /codon_start=1 FT /transl_table=11 FT /product="capsid protein" FT /note="ORF11; DNA packaging" FT /db_xref="UniProtKB/TrEMBL:B6RT43" FT /protein_id="ACB54910.1" FT /translation="MTDSLQVVEEKTKFRLGDFQFFAKKKEEDDQEEEEELEEEEEEEE FT EKPKPKRKSKSGEDAPAWAQEIIGLLKPKAEEQQTKQKVPVPEAPIVEDEEEEEPPKAS FT PLKSFLSRLW" FT CDS 5428..6135 FT /codon_start=1 FT /transl_table=11 FT /product="virion assembly protein" FT /note="ORF12" FT /db_xref="UniProtKB/TrEMBL:B6RT44" FT /protein_id="ACB54911.1" FT /translation="MGTRNNRTVETESGGTANKTESTSTRSTNSGGRGRGRTAESQSTE FT KLPKSVVVEVPNGEKSPEDTKKEEQRKAAAARKRKSRAAAATKKKSSPSIGDATQLKVL FT LLTTSQIIAAREGMSVWAMTEQEVDQIVTPLYSILSKNDGVGQVMGEYADHIALIVAAF FT TIFVPKFMMWKASRPKKEGTHYARPNPNSKREQGKQTGEVATSSRPSGGQPTNNGTTFG FT GQLSELVPPSAGI" FT CDS 5981..6232 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF13" FT /db_xref="UniProtKB/TrEMBL:B6RT45" FT /protein_id="ACB54912.1" FT /translation="MLDQIQIPNENKESKQERLQLVVDQVVDSLPTTVRLLAGSYLNSF FT RQVLESEQHDIDGNIDLALSRLREYIDYIQYGHDQENE" FT CDS 6241..6879 FT /codon_start=1 FT /transl_table=11 FT /product="DNA packaging ATPase" FT /note="ORF14; ATPase" FT /db_xref="GOA:B6RT46" FT /db_xref="InterPro:IPR000605" FT /db_xref="InterPro:IPR025662" FT /db_xref="InterPro:IPR027417" FT /db_xref="UniProtKB/TrEMBL:B6RT46" FT /protein_id="ACB54913.1" FT /translation="MERIPKDQHVFITGQTGTGKSFLAETYLAGYEHVIKLDTKGEVFE FT RRKKKQPVWRGLREGKDFTVIEHLDEIDSVETKKIIYAPVFQEQEMEYYDALMQWVYRR FT ENTQLWIDELMEVCPSPFKYPPYLKGLMTRGRSKEATVWACTQRPSDIPSIVMGNSDHF FT FVFDQNLPQDRKKLCETTGSYKFMELPGYRNFWYFKRGMTDPVLATLKL" FT CDS 6901..7041 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF15" FT /db_xref="GOA:B6RT47" FT /db_xref="UniProtKB/TrEMBL:B6RT47" FT /protein_id="ACB54914.1" FT /translation="MEGKFAGIGLKNILAIFFLFIVFIVVAKVIFTKYPIKGVSEVIQT FT V" FT CDS 7047..7196 FT /codon_start=1 FT /transl_table=11 FT /product="DNA packaging protein" FT /note="ORF16; transmembrane" FT /db_xref="GOA:B6RT48" FT /db_xref="UniProtKB/TrEMBL:B6RT48" FT /protein_id="ACB54915.1" FT /translation="MEMNLFSPKWWIGSIVTAFMTMFFIYLTKNIAAKANIPFVSKVTE FT EAYK" FT CDS 7196..8260 FT /codon_start=1 FT /transl_table=11 FT /product="major capsid protein" FT /note="ORF17; virion structure" FT /db_xref="UniProtKB/TrEMBL:B6RT49" FT /protein_id="ACB54916.1" FT /translation="MGQQQQLSAQQRAAYFGTATRQNYQMLPAQQVTQENSTVEFTLPK FT ARLLSKIYLNVEAVATLKSKGTAIQTHDFSPYTILRRVSLDLNNGFSPFIVSGRDLMQY FT NLLRLNPNVLFPASTPRGMNYIESGASVEGKDAKIKFTVELPVTLNQRDPVGLVLLQNA FT ETSVTLTVDVAQLANAYTLNASNTDQVLFKSMKVVPMVETFSIPPIPEAFPDISTLKLV FT SSKSDTFAGNGQNIVKLNTGTIYRKMLLYFEDKDGKPLEDTDFQGNIELVFNQADIPYS FT IKPEILSHINHSQLGYPLPKGLYALDFTNQGIPNLGGSRDFIDSERLTELWVRFSTLKE FT GKVTVVSENLSRLR" FT CDS 8306..8530 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF18" FT /db_xref="GOA:B6RT50" FT /db_xref="UniProtKB/TrEMBL:B6RT50" FT /protein_id="ACB54917.1" FT /translation="MAGEMSHFMKDVYPNMGFQNTTYISIPEAEDQQALVDDQKIAEES FT GKMENKAGHKNIMLGIVLILIIMFVLGKV" FT CDS 8536..8706 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF19" FT /db_xref="GOA:B6RT51" FT /db_xref="UniProtKB/TrEMBL:B6RT51" FT /protein_id="ACB54918.1" FT /translation="MEMEVAQFISNNGFAAFVAVFMLVKGSKDNQNMTAAINKLETAIT FT LLNGKKVEDDK" FT CDS 8783..9256 FT /codon_start=1 FT /transl_table=11 FT /product="DNA delivery protein" FT /note="ORF20" FT /db_xref="UniProtKB/TrEMBL:B6RT52" FT /protein_id="ACB54919.1" FT /translation="MDRGLTFFTLALLLIWLVFDDLFGNKKYLSKLAGSMTPNLSLPDP FT VRDMVDKTVEDTKENVKKDVADTKKDTKDAINDTKKSWDDFVNGGFEKEMKKDVNDFKD FT WMKDLPNPDKMKKKTNDDFKEIWDEINKSLEDTKKSAVDMWDDVTSSVKGWFK" FT CDS 9256..9432 FT /codon_start=1 FT /transl_table=11 FT /product="DNA delivery protein" FT /note="ORF21" FT /db_xref="GOA:B6RT53" FT /db_xref="UniProtKB/TrEMBL:B6RT53" FT /protein_id="ACB54920.1" FT /translation="MKEFTESLGFIVAFMTMTIFMSMFTNEAITNGFLMIVLASMLVLN FT SEKFTKMLDGVMK" FT CDS 9432..9578 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF22" FT /db_xref="GOA:B6RT54" FT /db_xref="UniProtKB/TrEMBL:B6RT54" FT /protein_id="ACB54921.1" FT /translation="MSRVLGIVSGIGMLIAVYLFLNNAKQTTQIIDSIAGNGVKGIKTL FT QGR" FT CDS 9591..9866 FT /codon_start=1 FT /transl_table=11 FT /product="minor capsid protein" FT /note="ORF23; virion structure" FT /db_xref="UniProtKB/TrEMBL:B6RT55" FT /protein_id="ACB54922.1" FT /translation="MLEGTYRNRVHNGQALQALTKRVEIPDARLGVGAAEHLEAMGIRV FT QYENKVPKLVLPSVHHLPFEQARPTKVEADMFVTNDFQIGDAIMGV" FT CDS 9870..10502 FT /codon_start=1 FT /transl_table=11 FT /product="DNA delivery protein" FT /note="ORF24" FT /db_xref="GOA:B6RT56" FT /db_xref="UniProtKB/TrEMBL:B6RT56" FT /protein_id="ACB54923.1" FT /translation="MAEIVPVGGGGHGSSPSKKKNKKMLFLAGGVGVVVLLVFLQRSKG FT GSSSGNVDTLQNTIPISDSQRLDNFQSIVSGETSAQINGMMKDAQDGWSGMFKDFSEKM FT TNQMKEMDERNKEYSKQQQEWVKDSFLNIKDSLGVGAIRNEDNAIFTVGKGTTGKQPYN FT EQLNDLRNDRQKLNEEIKRTQSVITYRKNNGLDVSAQVQHYKNLGEL" FT CDS 10502..11158 FT /codon_start=1 FT /transl_table=11 FT /product="glucosaminidase" FT /note="ORF25; DNA delivery protein" FT /db_xref="GOA:B6RT57" FT /db_xref="InterPro:IPR002901" FT /db_xref="UniProtKB/TrEMBL:B6RT57" FT /protein_id="ACB54924.1" FT /translation="MAADIRPFIADAQRIQKQTGIPASIILGQIIFESSGKNPGGLSGL FT AYNNKNLFGIKGKGTAGTANMWSKEYDAGGNRVSGFRSYNSYTESLNDHARLLQTDRYA FT KYLKNAKSVDDFARGIIKGGYATDPNYANQLLGIIKSNGLTKYDDGTYTFTGGDVSGGS FT AGGGGGGVSFFAPLFNAIVRGLLFFVCVVAALLLFAKAFPSVEQTVKSTAKKVKS" FT CDS 11155..11682 FT /codon_start=1 FT /transl_table=11 FT /product="pentameric base spike" FT /note="ORF26; peptidase; virion structure" FT /db_xref="GOA:B6RT58" FT /db_xref="InterPro:IPR009045" FT /db_xref="UniProtKB/TrEMBL:B6RT58" FT /protein_id="ACB54925.1" FT /translation="MSGTNGLKLNDKLQEAYNKAIGAGLRFTSGFRPGSKGPSGKADSH FT SQGMAMDFAGNPAQMAVFAEWAKKSGLFSEVLYKTAGHYDHVHVGWQENKHPAGKVYVG FT DHTLIDRVGGGTLGDLQTVGDTSAPAGGGDKAGFVSSLFNGIFRVLMIVICLIGGVYFF FT MNAFPQMKQLIK" FT CDS 11693..12607 FT /codon_start=1 FT /transl_table=11 FT /product="trimeric spike protein" FT /note="ORF27; virion structure" FT /db_xref="UniProtKB/TrEMBL:B6RT59" FT /protein_id="ACB54926.1" FT /translation="MDRKTNSTWREQTLTLPPKTVYDVVFPDTKPNHYHINNLSPAMIY FT LGVSIIASPQSYDIAVTGNGDNIHARDLGATRITLYNDSPDKARIVLTSFEDKFNPAVL FT SGRGSVTVSGGGGGGAGGVITGFNASLPSGDNNIGRVKISEMPAIDFVLGTLPAGSNNI FT GKVEVSKLPPLASVGGKIGDVGISGGVSITSMPPVQVTNDPVRSTCRAWSGAVDTTHVT FT FDMVDGDVLKFSYISNDGDTDLFINFDDAKANPDNLKGAGLSGKNASIWLKPGEIITEF FT TRKTTKVNMIRKSGNGIVRILGV" FT CDS 12611..13012 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF28" FT /db_xref="UniProtKB/TrEMBL:B6RT60" FT /protein_id="ACB54927.1" FT /translation="MGLKKPSGAPFMSAQGESFVTIESQKSATLEINNLSFTPNMIVIR FT CETQYGEVYQMTYHPFQMIYGINVTRGVNVDKNRPTYLSNDSYGLLTPSAKGFNAKLTP FT DTDIFRGSALFKWKAYYFPSVKEEAEKPF" FT CDS 13027..13383 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF29" FT /db_xref="UniProtKB/TrEMBL:B6RT61" FT /protein_id="ACB54928.1" FT /translation="MFVPLRIYYDKKTGLIIQYTGNFQDNNMIQAPTIEDDFTSYQSLN FT ERVKETVGVIELEQNQYKEELYKATNVTVDVKTGQLMFDFTPIVKKEIEEKKTLEQRIT FT LVESTINDILLGGM" FT CDS 13385..13534 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF30" FT /db_xref="UniProtKB/TrEMBL:B6RT62" FT /protein_id="ACB54929.1" FT /translation="MTVLSMKVRYILNQWLMGGFKDSDLPTLVDRGHITEEQRTYFLSL FT KEEK" FT CDS 13536..14294 FT /codon_start=1 FT /transl_table=11 FT /product="endolysin" FT /note="ORF31; cell wall degradation" FT /db_xref="GOA:B6RT63" FT /db_xref="InterPro:IPR002508" FT /db_xref="InterPro:IPR021976" FT /db_xref="UniProtKB/TrEMBL:B6RT63" FT /protein_id="ACB54930.1" FT /translation="MYDLYTFGAGHNFKVPGASGNGYKEEVETRRVVKRLLEICYQHGI FT KAVDTTDNDGRTQRENLNNIVRNCNSYPKNGRLDVAIHFNQAESETGGVEVWYYDQAGL FT AAKVSKDVAAALGLRDRGAKEGKGLAVLNGTNAPAILIELPFLSHVGNMQAYESNFEPM FT CRAIVQAVTGQQVAVNGIRPVSKNVIQTGAFSPYEATDAMTALTSLKMTGVFYLQANGL FT PYIVTDPTSDAQLEAAKEYFKRKDWWFDVK" XX SQ Sequence 14398 BP; 4975 A; 2353 C; 3212 G; 3858 T; 0 other; catggtgttc agcccatcta ataaattaat agggtagaag tattgacata catataaatt 60 tatgaaacac gatattaatt tccaattgac aattttccaa tttaccaact taccaatttt 120 agaaaatttc ctattggaaa gggtggaaaa gtgtgacatt attttttact agtgatataa 180 tagtgacaga acaaattcga acatccttta tgtcatcaga ctaagtgttc ggttttctgt 240 aacataactg taacattcca attattgcac atctacccaa tacatgctaa gataggtctt 300 gtaaggacaa cacaggacaa tgaagaacac taagtgatag ggtgtattca ttaaaggatg 360 tggggagatg aagtagaatg ctattctaca ctgtaaagga atttgcggaa atggctaaga 420 tttcagagaa gactgtgact aggtacatca agacgggtga tttggaagca gtcaagtttg 480 gcggacaatg gcgtatcact gaaacagcgg tacaaagcta tattaaaaat aattcaaata 540 tcggaggacg agaaaatgac taataaaaat gaacaattaa ataatggtgc tgtaacatct 600 tatgtggata ctgacatgct tgctaatggg gaacaaccaa tggtaattac tcctgaagta 660 aatacaaatg acatcgtgac agtggacaag gtgtcaccat ctattttcga agctcaaggc 720 ggtaaggatg tattcttttc ttctattcaa acgaaagacc gtaaatcagc tatcaaagtc 780 tacaacgcta tcaattctag cgaaaatcct ttagcagatc atcgtggtga agtgttacat 840 atcactgaca tggttgcaca tgcaattaca ttagaagatg atgttacaaa agaagatgtg 900 gacgcattac gtgtcgtatt agtggacaag gacggtaaag cataccatgc aatttcacaa 960 ggtgttgtgt catctattca aaagattatt agcatcgttg gaccagcacc atggacagac 1020 gagccacttg aaatcgtacc tgtagaagtg aagacacgta aaggattcaa aacattaact 1080 ctacaattac aaggttaatt tcgataacaa gtgaatgagg gtacacatta gtgtatcctc 1140 ttttttctaa aagaaagggt gcttgctagt ggatggtata aaagaagtgg tacaagtttc 1200 tattaaaacc aatgagcgtg acatcgaatt cacatcattt gcaggattga atcaaattaa 1260 acaatcgctt gatggtgatg tgtcatcggt cgtattaacg gatgaagaac tagaaatgat 1320 gttatgtgtg aagcagcgtg ataagttagc atcattcttc caatcggtgc tagaacgtaa 1380 gaatgcggta taaggcttta aaacctgtga catacgtgtc gcaggtttaa acagctttat 1440 aaggtaggtg agaacatggc taataaacgt caacgtaaaa agatagtgaa aaagaaacaa 1500 gaatcctttt tatcatcggt gggttattcg aagaaacaaa tgaaaacgat tagcacaact 1560 gatagagcaa aggtagtaaa gaaagaaaca tataaaaaga aaaagcgtga caagtatcac 1620 caagcaagat caatggggtt tggttctaaa gaagcaaaca aaatgagtag ttggtctgac 1680 tcacgcttta taaagtatat agaagaattt aattcttact atatgattgt catgtataaa 1740 gatgtaacag aagagacgga cagcgaagca ttacatatga ttaagaacca cacgaaaaga 1800 cgtagcacat ccaacttact tagaagtatt aaaggatggt tgtctgtaga taaaaatcaa 1860 ggttatatag gtggatatga aattcaagta ggtaagaaag acgaaataga tttccattta 1920 tatgcttata aacagcgaaa gtatttacaa gcatatagag gacaagggtt acaattaaaa 1980 cctctattaa acttattaga aaatatgatg gtattattat acatggtaga agctaaagac 2040 caatttgttg aggacttatg tacaaacttg agaaagctac catatgaaca ggcacatata 2100 aacgctaatt atatagaaga agaatttata acagatagaa gtgacttgca tttttaggag 2160 gtgcgatata gtgagtaata aacaaaaaaa agagcgtcaa aagcctgcga agcttttaac 2220 gctggacacg gaaacacgag gtttgacggg caacgtgttt cgtgtcggat tgtttgacgg 2280 tacaaattac tataaatcaa atacctttga cgagattctt gatttatttg aacagtataa 2340 agattatgag tgtcacgtat acgtccataa tttagatttc gatttagcta aaattgcaac 2400 tactctattt aaacgtgata gggtgcggtt cgctaaatcc atctttatta atggtaacgt 2460 tgtgacatta cattctgact ctatgatact acatgatagc cttagattgc tacctggaag 2520 tttagaaaaa ttatgtaagg atttcggatt aaccgacaat gcaaagaaag atttgtcgga 2580 agttatcaaa gaacagggat atgcggtata taaaaaagat ggtgtgacgt ttgataaaaa 2640 gaaatcgtta ggtaactatt ttgaaaacgt accagctgac gatccaacgc taaatgagta 2700 tttagaattt gactgtcgct cactgtatga aatattaaca attgttatgg acatagctaa 2760 tataggtctt gaaacacttg tgatgtgtcc aacaacagct tctcttgcta tgagagtgta 2820 taaggaacaa tatcgtgaac agtatgataa agtagcaaca catttttata tgggtgaatg 2880 gggacaattt ttagaagagc atgtacgaca atcctattat ggaggtcgta cagaagtatt 2940 tacaccacac ttaccacatg gttatcacta tgacgtaaac agtttatatc cgtatgtcat 3000 gaaaattgca aagtttcctg taggctatcc aaacctttta aaagatggac aagccgcgac 3060 gaaatggaaa cactggaaac gtagagcaat aggtgggggt gttatgtggt gtcgtgtaga 3120 tgtacccgag gatatgtata tacctgtatt acctaaacgt gacccgagcg ggaaactatt 3180 attccctgta ggtaagctag aaggtgtatg gacattacca gagttattag aagctgaaaa 3240 gaatggttgc acgatagaag caatctatca aatggtatat tgggaacaca tggaaccgat 3300 attcaaagag tttgttgagc attttgagga cttgaaaaag aactctaaag gagcaaaacg 3360 aacatttgca aaacttattc agaatagctt gtatgggaag tttggtatga atagggtgcg 3420 tgtcagtttg ggggacatgg aagaccgcta tgatctacac gaaaagcaaa taccatataa 3480 agaatttaaa catgattgta atgggttaac actagaattt attcaatata taagcgaaag 3540 taaggctagt tacatacaac ctcatattgc aacctatgtg acagcctatg cacgtatcct 3600 tttatttaga gggttaaagg aacaagctag taaaggtgtg ctaggatact gtgacacgga 3660 ttctattgca ggtacggcaa aaatgcctga tgaaatgatt catgatgaag attatggtaa 3720 gtgggcgtta gaaggtgaac tagaagaagg tatattcttg caacccaaat tctatgcgga 3780 acgctataca aacggaaaag aagtcattaa ggcaaaagga atacctcgtg agaaaatgga 3840 agagttgtct tttgagaatt acaaggaatg gcttgaaatc atgaaagaag ggcaacagga 3900 acgtatcgac attttcgaag gatatgagtc acgcaagaaa ttttcaacaa cattaaaagc 3960 atctgaggat tttgacacat tacgtgaaat gaagaaatct attaatttat tattagaaca 4020 aaagcgtgac attgattata aagggaatgt aacaagacct cataaacgtt acgattacgg 4080 ggataagaag gacaagattg attatgaaga ttataagtct agagaagata aattaaacaa 4140 tatgtatgat gatgtagacg atctaaaaga gcaagtggac gaaataggtt acatcaaatg 4200 tatgaaacaa ggtgacatgt attttgagga atacaaacat ttaacaaagt cagttaaaag 4260 taaatatttt cgtagaacgg ggacacctat agacgtatgg gcgaatgagt cgggatggga 4320 tgttaacgaa ttactagaag aattacgatt gatgggggta tgttaaaatg ttaaccgata 4380 gagaacaaga agcgttagcg tgtataagcg ggtatatgag acaaaacggg tttgcaccat 4440 ccgtgcgaga aatggctggt ttattatttg tcagtcacaa gaccgcacat cgttatatga 4500 ttcaattaga aaccaaagga cacattaaga gaatacatca tcgttcacgt gctatccaac 4560 tatgtgtata aaaggaggaa tagagcatgc gtgataaagt tttagactta atcattgaac 4620 tatccaaatc aacaaaacag gtcgtagcaa aagatttcat tattaatgaa ttatataaaa 4680 tagcaaaaga agatgaatcg aaagagaagg agactagcaa ataaatgcta gtctttttat 4740 ttgtccaaaa tgacacattt gtgacgttac aagcgaacat atgtttgggt tatacttgtc 4800 acatcaagca ataaggagtg acaaaaatgg aaggtattga tttaagtcat gtgcaatgtt 4860 cattgccacc tattccaaac ccgttaacgt ttgaagattt aacagaagaa caatttaaag 4920 cgttattaaa tgttattcat gattttaaat tcgcttgtag agaaagtaat ttaccacttg 4980 ctttctatta tgtattagaa aaatgtactg accctgtagt gaaacaagaa ttaatagatg 5040 ctcatagata tgggtgttaa ggagtgtaca agatgttcaa aacattatca aaactgtacc 5100 gtgacttatt acatcaaaac atagatttgc acaatgaaaa tacaaaacta cgattacaaa 5160 atgcacggct gcaaagtaag ttagcaaccg ctgaaataga tttataccat tttaaaaatt 5220 caatagaaag gatgattaac aaatgacaga ctcattacaa gtagtggaag aaaaaacgaa 5280 atttagatta ggagattttc aattctttgc aaagaagaaa gaagaggacg atcaagagga 5340 agaagaggaa cttgaggaag aggaagaaga ggaagaagaa aagccgaaac caaaacgtaa 5400 atcaaaaagc ggggaggatg caccagcatg ggcacaagaa ataatcggac tgttgaaacc 5460 gaaagcggag gaacagcaaa caaaacagaa agtaccagta cccgaagcac caatagtgga 5520 ggacgaggaa gaggaagaac cgccgaaagc cagtccactg aaaagcttcc taagtcggtt 5580 gtggtagaag tcccgaacgg tgagaagtca cccgaggaca ccaaaaagga agaacaacga 5640 aaggcagcag ccgcacgaaa acgtaaatca cgtgcagcag ccgcaacgaa aaagaagtcg 5700 tcaccatcta ttggtgatgc aacgcaatta aaagtattgc ttcttactac gtcacagatc 5760 atagcagcaa gagaaggtat gagcgtatgg gcgatgacgg aacaagaggt tgaccaaatt 5820 gttacaccgc tttatagcat cctatctaaa aatgatgggg tggggcaagt catgggtgaa 5880 tatgccgacc acattgcttt aatcgtggca gcatttacta tatttgtacc aaaatttatg 5940 atgtggaaag catcaagacc taagaaggag ggaacgcact atgctagacc aaatccaaat 6000 tccaaacgag aacaaggaaa gcaaacagga gaggttgcaa ctagtagtag accaagtggt 6060 ggacagccta ccaacaacgg tacgactttt ggcgggcagc tatctgaact cgttccgcca 6120 agtgctggaa tctgaacagc atgacattga cggaaacatt gatttagcct tgtcacgttt 6180 acgtgagtac atcgactata tccaatatgg tcacgatcaa gaaaatgagt aggtgaagac 6240 atggaacgta tcccaaaaga ccaacacgta tttatcacgg gacaaacggg tacggggaaa 6300 tcttttcttg ctgaaacgta tttagcaggt tacgaacatg taattaagtt agatacaaaa 6360 ggtgaggtgt ttgaaagacg aaaaaagaaa cagcctgtat ggcgtgggtt acgtgaagga 6420 aaggacttta cagtcataga gcatttagac gaaatcgaca gcgtggaaac aaagaaaatc 6480 atttatgcac ctgtctttca agagcaagaa atggaatact atgatgctct catgcaatgg 6540 gtgtacagga gagaaaatac acaattatgg attgatgaac tcatggaagt atgcccgagt 6600 cctttcaaat accctcccta cctcaaaggt cttatgacta gaggacgttc aaaagaagct 6660 actgtgtggg cgtgtacgca acgcccgagt gacattcctt ctattgtaat ggggaatagt 6720 gaccactttt tcgtctttga ccaaaacttg ccacaagatc gtaagaagtt atgtgagaca 6780 acgggtagtt ataagtttat ggaattaccg ggctatcgta acttttggta ttttaagcgt 6840 ggcatgacag atcccgtact cgccacattg aaattatgat ccttgaaagg gggtgtttag 6900 gtggagggga aatttgcagg gattggactg aaaaatattt tagccatctt ctttttattc 6960 attgtattta tagttgttgc taaagtaatt ttcacgaagt atcccataaa aggcgttagt 7020 gaagtaatac aaactgtata ggaggaatgg aaatgaattt atttagccct aaatggtgga 7080 ttggttctat tgtcacagca ttcatgacaa tgttctttat ttacctaacg aaaaatattg 7140 cagcaaaagc aaacatcccg tttgtatcaa aagttactga ggaggcttac aagtaatggg 7200 tcaacaacaa caattatctg cacaacaacg tgccgcatat ttcggtacag caacgagaca 7260 gaactatcaa atgctaccag cacagcaagt cacacaagaa aatagcacgg tagaatttac 7320 cctgccaaaa gcacgtttat tatcaaaaat ttatttaaat gtagaagccg tagcgactct 7380 aaagagtaaa gggacagcca tccaaacgca cgacttctca ccatatacta ttttacgacg 7440 tgtatcacta gacctcaaca acggattcag tcctttcatt gtaagtggtc gagacttaat 7500 gcaatataac ttgctgcgtt taaatccaaa tgtattattc ccagcttcta cacctagagg 7560 tatgaactat atcgaaagtg gggcatccgt ggaaggtaaa gatgcaaaga ttaaattcac 7620 tgttgaatta cctgtcacac taaaccaacg tgaccctgta ggacttgtgt tattgcaaaa 7680 tgctgaaaca agtgtaaccc taactgtcga tgttgcacag ttagcaaatg catatacatt 7740 aaatgcttct aacacggatc aagttttatt taaatctatg aaagttgttc cgatggtcga 7800 aacgtttagc attccaccga ttccagaagc attccctgac atttcaacac tgaaactagt 7860 ttctagtaaa tcagatacat ttgcgggtaa tggacaaaac atcgtgaaat taaacacggg 7920 tacaatttac cgcaaaatgc tgttgtactt tgaagacaag gacgggaaac cgctagaaga 7980 cacggatttc caagggaaca ttgagcttgt ctttaaccaa gccgatatcc cttatagcat 8040 caagcccgaa attctgtcac atatcaatca cagtcaatta ggctatccat taccaaaagg 8100 attatatgct cttgacttca cgaatcaagg gattccaaat ttaggcggta gtcgtgactt 8160 tattgattca gaacgtttaa cagaattgtg ggttcgcttc tcaacattaa aagaaggaaa 8220 agtgacagtc gttagtgaga acttgtcacg cttacgataa gaagagggga tttccccttt 8280 tcttctatat aaggagggac attgcatggc tggagaaatg agtcatttta tgaaagatgt 8340 atatccaaac atgggttttc aaaatacaac ctatatatcc attcccgaag cggaagacca 8400 acaagcatta gttgacgatc aaaagattgc tgaagagtcg gggaaaatgg aaaacaaggc 8460 gggacataaa aatatcatgc tggggattgt cttgatctta attattatgt tcgtactagg 8520 aaaggtgtga gtctaatgga aatggaagta gcacaattta ttagcaataa cgggtttgca 8580 gcattcgtag ccgtttttat gcttgtcaaa ggttcaaagg acaaccaaaa tatgacggct 8640 gccattaata aattagaaac agctattaca ttattaaatg gaaagaaagt cgaggacgat 8700 aaatgagcaa aacattaatt ctcgtggttg cgattttctg tttatggttt ttcgtaatca 8760 agaaaaagaa agcgtgatgt aaatggatag agggttaaca ttcttcacat tggcattgct 8820 gctgatatgg ctagtctttg acgacctttt tgggaacaag aaatacttgt ctaaattagc 8880 gggctctatg acaccgaatt tatcccttcc tgatcctgta cgggacatgg tggataagac 8940 cgtggaagac acgaaagaga atgtgaagaa agatgttgct gacacgaaaa aggatacgaa 9000 agatgccatt aacgatacaa agaaatcatg ggatgacttt gtgaatggtg gctttgaaaa 9060 agaaatgaaa aaggatgtca atgactttaa agattggatg aaagaccttc ctaatcctga 9120 caagatgaaa aagaaaacca atgatgattt caaagaaata tgggatgaaa tcaataagtc 9180 attagaagac accaaaaagt cagccgttga tatgtgggat gatgtcacat catcggtgaa 9240 agggtggttc aaataatgaa agaatttacg gagtcactcg gatttattgt agcgtttatg 9300 accatgacaa ttttcatgtc tatgtttacg aatgaagcca ttacaaatgg ttttctcatg 9360 atcgtactcg cttctatgtt ggtactcaat tccgagaagt ttacaaaaat gttagatggg 9420 gtgatgaaat aatgagtcgt gtactaggaa ttgtttcggg tattggtatg ttaattgctg 9480 tttacctgtt tttaaataat gcgaaacaaa caacgcaaat cattgacagc attgctggga 9540 atggtgtgaa gggtatcaaa acattacaag gtcgataagg agggtgtgac atgttagaag 9600 gcacgtatag aaatcgtgtg cataacggac aagccttgca agcacttact aagcgggtag 9660 aaattcccga tgcccgttta ggtgtcggtg ctgcggaaca tttagaagca atgggtatcc 9720 gtgtgcaata tgaaaataaa gtaccaaaac tggtattacc ttctgtacat catttaccgt 9780 tcgaacaagc acgacctact aaagtagaag ccgatatgtt tgtcacaaat gactttcaaa 9840 ttggtgacgc cattatgggg gtgtaaagaa tggctgaaat tgtaccagtt ggtgggggcg 9900 ggcatggctc gtctccttct aaaaagaaaa ataagaaaat gttatttctt gctggcggtg 9960 taggtgttgt tgttctactt gttttcttgc aacgttcgaa aggtggaagt agtagcggga 10020 atgtagatac cctgcaaaat acgattccta tttcggattc ccaaaggctc gacaattttc 10080 aatctattgt gagcggggaa acatcggcac agatcaacgg catgatgaaa gatgcacagg 10140 acggttggtc gggaatgttc aaggacttta gcgaaaaaat gaccaatcaa atgaaagaaa 10200 tggatgaacg caacaaggaa tattccaaac aacagcaaga atgggtgaag gattcctttt 10260 taaatattaa ggactcgcta ggtgtgggag caattcgaaa tgaagataac gcaatattta 10320 cggtgggtaa aggaacaaca gggaaacagc cgtataacga acaattaaac gatttacgca 10380 atgaccgcca aaagctgaac gaggaaatca aacgtacaca atccgttatt acctatcgta 10440 aaaacaacgg tctagacgtt tccgctcaag tacagcacta caagaattta ggtgaattgt 10500 aatggctgcg gatattcgtc cattcattgc tgatgcacag cgaatccaaa aacaaacggg 10560 tatccccgca tctattatat taggtcaaat catttttgaa tcaagcggga aaaaccccgg 10620 tggtttatca ggacttgcct ataacaacaa gaaccttttc gggatcaaag gaaaaggaac 10680 ggctgggaca gcgaatatgt ggtcaaaaga atatgatgcg ggagggaatc gggtttctgg 10740 tttccgctcg tataattctt atacagaatc actaaatgac catgcaagat tgctgcaaac 10800 agaccgctat gcaaagtatt taaaaaatgc gaaatcagtg gatgactttg caagagggat 10860 tataaaaggt ggttacgcca cagatccaaa ttatgcaaac caactattag gcattattaa 10920 atcaaacgga cttactaaat acgatgatgg aacatacacc tttacgggtg gtgatgtgtc 10980 gggcggttct gctggtggtg gaggtggcgg ggtttccttc tttgccccac tatttaacgc 11040 cattgtacga ggtctcttat tctttgtatg tgtcgtggct gccttgctat tattcgcaaa 11100 agcatttcca agcgtggaac aaactgtcaa gtcaacagcg aagaaggtga agtcatgagt 11160 ggtactaatg gtctcaaact aaacgataag ctgcaagaag cctataacaa ggcgattggt 11220 gcggggttac gttttacaag tggtttccgt cctggatcaa aaggaccgag cggaaaagcc 11280 gatagccatt cccaaggcat ggcaatggac tttgcaggga atcccgctca aatggctgtc 11340 tttgccgaat gggcgaaaaa gtcgggtctc ttttcagaag tgttatataa aacggctgga 11400 cactacgatc atgtacatgt gggctggcaa gaaaacaaac atcctgctgg gaaagtatat 11460 gttggcgacc atacactcat tgaccgtgta ggtggcggga ctttaggtga cttgcaaaca 11520 gtcggtgaca cttctgcacc tgctggtggc ggagacaagg cgggtttcgt gtcttcccta 11580 tttaacggca tatttcgagt attaatgatt gtgatatgtc taatcggtgg cgtgtacttc 11640 tttatgaatg cattcccgca aatgaaacaa ttaatcaaat gaggtgaaaa cattggatag 11700 aaaaacaaat agtacgtgga gggagcaaac cctcacatta ccaccgaaaa cggtgtatga 11760 cgttgtattc cctgatacaa agccaaacca ttaccatatt aataatttat cacctgcaat 11820 gatttattta ggtgtatcca ttattgcatc accacaatcc tatgacattg ccgtgacagg 11880 taacggggac aacatacatg cacgtgacct cggtgcaact cgaatcactt tatacaatga 11940 cagtcctgat aaggctcgaa ttgttttaac atcgtttgaa gataagttta accctgctgt 12000 gctttcaggt cgtggtagcg ttacggtttc gggtggtggc ggtggtggtg ctggtggtgt 12060 cattactggt ttcaacgctt cccttcctag cggtgataat aatatcggtc gggtaaaaat 12120 ttcggaaatg cctgcaattg attttgtact cggtacatta cccgctggtt cgaacaatat 12180 aggtaaagtg gaagttagca aattaccacc acttgctagt gttggtggga aaattgggga 12240 tgtcggaatt tcgggaggcg tgtcgattac ctctatgcca cctgtgcaag taacaaatga 12300 tcctgtacgt agtacatgtc gtgcatggag tggtgcggtt gatactacac atgtaacctt 12360 tgatatggtt gacggggatg tgttgaaatt cagttatata tccaatgatg gtgatacaga 12420 cctattcatt aattttgatg atgctaaagc aaaccccgat aacttgaaag gtgcgggatt 12480 atcaggaaag aatgcttcta tatggttaaa acctggtgag atcattacag aattcactag 12540 aaagacaact aaggtgaaca tgattaggaa atcaggtaac ggtatcgttc gaatactggg 12600 ggtgtaatag atgggactga aaaaacctag cggtgcaccc tttatgtcag cgcaggggga 12660 atcgtttgta acaatagaat cccaaaaatc agctacatta gaaattaata atttatcatt 12720 cacacctaat atgattgtga ttagatgtga aactcaatat ggtgaggtct atcaaatgac 12780 ctatcatcct tttcaaatga tttacggtat caatgtaaca agaggggtaa atgtagataa 12840 aaatcgccct acttatttat caaatgattc ttatgggtta cttacaccaa gtgcaaaagg 12900 atttaatgct aagttaactc ctgacacgga tatttttaga ggtagcgcat tatttaaatg 12960 gaaagcttat tatttccctt cagtaaaaga ggaagcggaa aaaccattct aaaaggaggg 13020 aactatatgt ttgtaccatt acggatttac tacgataaga aaacagggtt aatcattcaa 13080 tacactggta actttcaaga taacaacatg attcaagcac ctaccattga agatgatttt 13140 acgagttatc aatctttaaa tgaaagagtg aaagagactg taggtgttat tgaactagaa 13200 caaaaccagt ataaggaaga attatataaa gcaacaaacg tgactgttga tgtaaagaca 13260 ggtcaactta tgtttgattt tacacctatt gttaaaaagg aaatcgaaga gaaaaagaca 13320 ctggaacaac gtatcacatt agttgaaagt acaattaacg atattctatt aggaggaatg 13380 taaaatgaca gttttatcta tgaaagtacg ttacatttta aatcaatggt taatgggtgg 13440 tttcaaagat agcgaccttc caacactggt agatcgtgga catattacag aagaacaacg 13500 cacttacttc ttgtcattga aggaggaaaa atagtatgta tgatttatat acgtttggtg 13560 ctggtcacaa ttttaaagta cccggggcaa gtggaaacgg atataaggaa gaggtagaga 13620 caagacgggt tgtaaaacgg ttgttagaga tatgttacca gcatggtatt aaagctgtag 13680 ataccactga taatgatggt agaacacaac gtgagaatct aaacaacatc gttcgtaatt 13740 gtaatagcta ccctaaaaat ggtcgtcttg atgtagctat ccattttaac caagcggaaa 13800 gcgaaacagg tggtgttgag gtttggtatt acgatcaagc tggacttgct gcaaaggtaa 13860 gtaaagatgt ggctgctgca ctcggtttac gtgaccgtgg ggctaaagag gggaaaggtc 13920 ttgccgtact gaatggaaca aacgccccag ctatattgat agagttgccg tttctatcac 13980 atgtagggaa tatgcaagcg tatgaatcca atttcgagcc tatgtgtaga gccattgtac 14040 aagccgtgac ggggcaacag gttgcggtga atgggatacg tcctgttagc aagaatgtta 14100 ttcagacggg ggcattctca ccgtatgaag cgactgatgc aatgacggca ttaacgtcac 14160 taaaaatgac aggggtgttc tatttacaag caaatgggtt accatatatt gtcacagacc 14220 cgacatcgga tgcacagtta gaagctgcaa aagaatattt caaaagaaaa gattggtggt 14280 ttgatgttaa gtagacctag cgaaaagcta ggtttttatt ttggaattta atatatcgta 14340 aatcatagat gtttattatt gtcaataggg aatttagtca gatgggctga acaccatg 14398 //