ID CP001902; SV 1; circular; genomic DNA; STD; PRO; 12197 BP. XX AC CP001902; ADCA01000000-ADCA01000033; XX PR Project:PRJNA37943; XX DT 19-FEB-2010 (Rel. 103, Created) DT 15-MAY-2014 (Rel. 120, Last updated, Version 4) XX DE Methanocaldococcus sp. FS406-22 plasmid pFS01, complete sequence. XX KW . XX OS Methanocaldococcus sp. FS406-22 OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales; OC Methanocaldococcaceae; Methanocaldococcus; unclassified Methanocaldococcus. OG Plasmid pFS01 XX RN [1] RP 1-12197 RG US DOE Joint Genome Institute RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., RA Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Larimer F., Land M., RA Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Leigh J., RA Whitman W.B., Woyke T.; RT "Complete sequence of plasmid of Methanocaldococcus sp. FS406-22"; RL Unpublished. XX RN [2] RP 1-12197 RG US DOE Joint Genome Institute RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., RA Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Larimer F., Land M., RA Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M., Leigh J., RA Whitman W.B., Woyke T.; RT ; RL Submitted (02-FEB-2010) to the INSDC. RL US DOE Joint Genome Institute, 2800 Mitchell Drive B310, Walnut Creek, CA RL 94598-1698, USA XX DR MD5; 3b2dbb8aa3d00028d4a3e4bd5dd5d8c0. DR BioSample; SAMN02598520. DR EnsemblGenomes-Gn; EBG00001113919. DR EnsemblGenomes-Gn; EBG00001113920. DR EnsemblGenomes-Gn; EBG00001113921. DR EnsemblGenomes-Gn; EBG00001113922. DR EnsemblGenomes-Gn; EBG00001113923. DR EnsemblGenomes-Gn; EBG00001113924. DR EnsemblGenomes-Gn; EBG00001113925. DR EnsemblGenomes-Gn; EBG00001113926. DR EnsemblGenomes-Gn; EBG00001113927. DR EnsemblGenomes-Tr; EBT00001705075. DR EnsemblGenomes-Tr; EBT00001705076. DR EnsemblGenomes-Tr; EBT00001705077. DR EnsemblGenomes-Tr; EBT00001705078. DR EnsemblGenomes-Tr; EBT00001705079. DR EnsemblGenomes-Tr; EBT00001705080. DR EnsemblGenomes-Tr; EBT00001705081. DR EnsemblGenomes-Tr; EBT00001705082. DR EnsemblGenomes-Tr; EBT00001705083. DR RFAM; RF01358; CRISPR-DR39. XX CC URL -- http://www.jgi.doe.gov CC JGI Project ID: 4086483 CC Source DNA and organism available from William B. Whitman CC (whitman@uga.edu) CC Contacts: William B. Whitman (whitman@uga.edu) CC Tanja Woyke (microbe@cuba.jgi-psf.org) CC Annotation done by JGI-ORNL and JGI-PGF CC Finishing done by JGI-LANL CC Finished microbial genomes have been curated to close all gaps with CC greater than 98% coverage of at least two independent clones. Each CC base pair has a minimum q (quality) value of 30 and the total error CC rate is less than one per 50000. CC The JGI and collaborators endorse the principles for the CC distribution and use of large scale sequencing data adopted by the CC larger genome sequencing community and urge users of this data to CC follow them. it is our intention to publish the work of this CC project in a timely fashion and we welcome collaborative CC interaction on the project and analysis. CC (http://www.genome.gov/page.cfm?pageID=10506376). CC ##Metadata-START## CC Organism Display Name :: Methanocaldococcus sp FS406-22 CC GOLD Stamp ID :: Gi02050 CC Greengenes ID :: 179917 CC Isolation Site :: Deep-sea hydrothermal vent from Pacific CC Ocean Axial volcano on the Juan de Fuca CC Ridge CC Latitude :: 23.366667 CC Longitude :: -44.933333 CC Cell Shape :: Coccus-shaped CC Motility :: Motile CC Sporulation :: Nonsporulating CC Temperature Range :: Thermophile CC Temperature Optimum :: 90C CC Gram Staining :: gram- CC Biotic Relationship :: Free living CC Diseases :: None CC Habitat :: Deep sea, Hydrothermal vent, Marine CC Phenotypes :: Piezophile CC Energy Source :: Lithotroph CC ##Metadata-END## XX FH Key Location/Qualifiers FH FT source 1..12197 FT /organism="Methanocaldococcus sp. FS406-22" FT /plasmid="pFS01" FT /strain="FS406-22" FT /mol_type="genomic DNA" FT /db_xref="taxon:644281" FT gene complement(439..858) FT /locus_tag="MFS40622_1837" FT CDS complement(439..858) FT /codon_start=1 FT /transl_table=11 FT /locus_tag="MFS40622_1837" FT /product="conserved hypothetical protein" FT /note="KEGG: mja:MJ1489.1 hypothetical protein" FT /db_xref="EnsemblGenomes-Gn:MFS40622_1837" FT /db_xref="EnsemblGenomes-Tr:ADC70506" FT /db_xref="GOA:D3S8R5" FT /db_xref="UniProtKB/TrEMBL:D3S8R5" FT /inference="similar to AA sequence:KEGG:MJ1489.1" FT /protein_id="ADC70506.1" FT /translation="MNDKITYFIDNTISIIKLTLMTYLVIAIGIMFQPLQYPTNISIIF FT MVIIGIGLLFAFQFILGYGFDIYKQLSIEDRIEFYNYVVRKIFNILIEHSYYGLLLSTY FT NLFVYKKAIAIGLCCIATLGIITFWILGNKLIKNG" FT repeat_region 1357..1866 FT /rpt_unit_range=1357..1388 FT /note="CRISPRS" FT gene complement(2429..2734) FT /locus_tag="MFS40622_1838" FT CDS complement(2429..2734) FT /codon_start=1 FT /transl_table=11 FT /locus_tag="MFS40622_1838" FT /product="hypothetical protein" FT /note="KEGG: 1-aminocyclopropane-1-carboxylate synthase" FT /db_xref="EnsemblGenomes-Gn:MFS40622_1838" FT /db_xref="EnsemblGenomes-Tr:ADC70507" FT /db_xref="UniProtKB/TrEMBL:D3S8R6" FT /inference="ab initio prediction:Prodigal:1.4" FT /protein_id="ADC70507.1" FT /translation="MLNLFKKDKKEDYREKENYQSIHNVVKAHYDDFLANINNGMNGGV FT KRAGISFPENLHDFLYICSKYEKITVSKLVVDLLLFVLEDKERFNEFLKEKYGKKL" FT gene complement(2773..4047) FT /locus_tag="MFS40622_1839" FT CDS complement(2773..4047) FT /codon_start=1 FT /transl_table=11 FT /locus_tag="MFS40622_1839" FT /product="integrase family protein" FT /note="PFAM: integrase family protein; KEGG: FT mmq:MmarC5_1487 phage integrase family protein" FT /db_xref="EnsemblGenomes-Gn:MFS40622_1839" FT /db_xref="EnsemblGenomes-Tr:ADC70508" FT /db_xref="GOA:D3S8R7" FT /db_xref="InterPro:IPR011010" FT /db_xref="InterPro:IPR013762" FT /db_xref="UniProtKB/TrEMBL:D3S8R7" FT /inference="protein motif:PFAM:PF00589" FT /protein_id="ADC70508.1" FT /translation="MGRNRPLHHQLKYAVMQSYRHRGQRRQFKQQWQELDKAYERGDIT FT FEEWLKEKSKIWFVASRGDFWRGNRHKEGYLDSLIKFANNFGRWIQNEFKVKRACDITP FT EMTQLFLECKAKEGVRATTLKKYVSMIKALNLACAKTYGLKWNFKFAKGIYVPQHALQQ FT EARTIRIEPEDYKRVINSEYFQKSKSKAKIGIVLARHFALRVNEIAKLKYGDVVLDERA FT IPDSLKRFMVGKSIYNAYLIVKNSKHGLHRVIPAHTEKEYELLKSIKEHQIKNNILDDV FT EIVGLDKDSVNAFFRRCLKNCGLNYYVEKGVNIHGLRKLRASELFLEKLKEIYTNVYAG FT KNMPLKKKIYLSFKKAGAYVDKYLGHENKSKGKQHLKREGRWDLIKKYQLDVLKPEDIA FT MALVECGLDYETALETVKEVLTDLN" FT gene 5388..5573 FT /locus_tag="MFS40622_1840" FT CDS 5388..5573 FT /codon_start=1 FT /transl_table=11 FT /locus_tag="MFS40622_1840" FT /product="regulatory protein MerR" FT /note="PFAM: regulatory protein MerR; KEGG: tsi:TSIB_2042 FT IS element ISTsi1 orfA, putative resolvase" FT /db_xref="EnsemblGenomes-Gn:MFS40622_1840" FT /db_xref="EnsemblGenomes-Tr:ADC70509" FT /db_xref="GOA:D3S8R8" FT /db_xref="InterPro:IPR009061" FT /db_xref="InterPro:IPR010093" FT /db_xref="InterPro:IPR041657" FT /db_xref="UniProtKB/TrEMBL:D3S8R8" FT /inference="protein motif:PFAM:PF00376" FT /protein_id="ADC70509.1" FT /translation="MKYYSAREAAKILGVAHTTVIRWIEKGELKANIRKTLYRVYYQIP FT EDEVLRLKKRLEAQHD" FT gene 5698..8022 FT /locus_tag="MFS40622_1841" FT CDS 5698..8022 FT /codon_start=1 FT /transl_table=11 FT /locus_tag="MFS40622_1841" FT /product="MCM family protein" FT /note="PFAM: MCM family protein; SMART: MCM family protein; FT KEGG: mfe:Mefer_1152 MCM family protein" FT /db_xref="EnsemblGenomes-Gn:MFS40622_1841" FT /db_xref="EnsemblGenomes-Tr:ADC70510" FT /db_xref="GOA:D3S8R9" FT /db_xref="InterPro:IPR001208" FT /db_xref="InterPro:IPR012340" FT /db_xref="InterPro:IPR027417" FT /db_xref="InterPro:IPR031327" FT /db_xref="InterPro:IPR033762" FT /db_xref="InterPro:IPR036388" FT /db_xref="InterPro:IPR041562" FT /db_xref="UniProtKB/TrEMBL:D3S8R9" FT /inference="protein motif:PFAM:PF00493" FT /protein_id="ADC70510.1" FT /translation="MSPNEYIIDKIYNIFERERKKHPTYKESKYDKESEYKELIKFLVE FT KEEVNEAELMLKAKEIGLGRLYYNTFIAILKKYLNFIDIGEEDGYKVIKITNELRNVLN FT DDNESDESNFKIDMEFIIMQYEDLLRKYLKNYITVVGPEKLERKIRLSARDLSAEFGDM FT IDYAIESVDNYYQVVDYLTKLFNEVYYEITYEMGDFKVVLCDFPALEIDVNKINAEYVN FT KVVEFEANIIYASHVSVFVKKSVFQCPRCGKIVNVYLRDFFAKNSDKLVCNECNVKLQH FT IKDEEYTNFQELIVQGLPNEKGYIREQRVLYEDSDGVFSGYVKITGIVRTVPRSSKSKV FT YDLVVQAVDVEEIDNIAPRLTKKDIEDIKKIAKRKDVIDLLSDRLIPEIKGHSLVKKAV FT FLQQIRGVKKPGKRDKINILLITDPGIGKTVILRKIAEIPGNNYVSMPTSTINSVFAIA FT EKKKSLSGESWTVKVGPVPKSIGTVCIDEFYIPKGDTTFYEAMEGDVIHFCKGGIDARL FT QSVCSFLCARNPRWGRFNPDVSVAEQIDIPAPLLSRFDLIFPIRDRADKEADKEIAEHI FT IDVHRAYLDKEVNKKIRLDYIKIDGVIIDFEFIVKYIFYARQLKPVMTGETKKKLVNWY FT VEMRKKHNITARQLEAAVRLAEAHAKAKLKDVVDVEDAEEAIGMITECLKEIAYDPETG FT IFDIDKIMGVHSSERKKLDIVYNAIEELSHGSSEVLVGFDEILNFVEEKGINEKELERL FT LNKLKKFGDIDEPKPGRYRLI" FT gene 8074..8406 FT /locus_tag="MFS40622_1842" FT CDS 8074..8406 FT /codon_start=1 FT /transl_table=11 FT /locus_tag="MFS40622_1842" FT /product="conserved hypothetical protein" FT /note="KEGG: mja:MJ1074 hypothetical protein" FT /db_xref="EnsemblGenomes-Gn:MFS40622_1842" FT /db_xref="EnsemblGenomes-Tr:ADC70511" FT /db_xref="GOA:D3S8S0" FT /db_xref="UniProtKB/TrEMBL:D3S8S0" FT /inference="similar to AA sequence:KEGG:MJ1074" FT /protein_id="ADC70511.1" FT /translation="MAVSYARIYELLLKYVKDEKKAMECYDVVVEVIKEIEREAREGVK FT DDLRDELATKKDIALLEEKMNSMEERILRYVDNKFNQIKILILITLFAVIVLNPYAYEI FT VKAILK" FT gene 8435..8653 FT /locus_tag="MFS40622_1843" FT CDS 8435..8653 FT /codon_start=1 FT /transl_table=11 FT /locus_tag="MFS40622_1843" FT /product="conserved hypothetical protein" FT /note="KEGG: mja:MJ1072 hypothetical protein" FT /db_xref="EnsemblGenomes-Gn:MFS40622_1843" FT /db_xref="EnsemblGenomes-Tr:ADC70512" FT /db_xref="GOA:D3S8S1" FT /db_xref="UniProtKB/TrEMBL:D3S8S1" FT /inference="similar to AA sequence:KEGG:MJ1072" FT /protein_id="ADC70512.1" FT /translation="MLENELATKNDIALLEERMNSMDEKILRYVDNKFYELDKKTDRIF FT YLIIVFMIVYVLTNPQVVGVIKLIFMK" FT gene 8672..9103 FT /locus_tag="MFS40622_1844" FT CDS 8672..9103 FT /codon_start=1 FT /transl_table=11 FT /locus_tag="MFS40622_1844" FT /product="zinc finger C2H2-type domain protein" FT /note="PFAM: zinc finger C2H2-type domain protein; KEGG: FT mja:MJECS06 hypothetical protein" FT /db_xref="EnsemblGenomes-Gn:MFS40622_1844" FT /db_xref="EnsemblGenomes-Tr:ADC70513" FT /db_xref="UniProtKB/TrEMBL:D3S8S2" FT /inference="protein motif:PFAM:PF00096" FT /protein_id="ADC70513.1" FT /translation="MDIDKYIENLEIKKEGFFYKCPYCDYTNADLKVIKKHIKTKHLDE FT IKKEVEKMNKPKQKQNKQRRMPQRKQVKKEDDYKDYLLLFAHKKKCKIHLDNGMVVEGL FT VKAKDKYNIMVLDARADGKDVGRMIIQKGHIVALIPLEE" FT gene 9143..9586 FT /locus_tag="MFS40622_1845" FT CDS 9143..9586 FT /codon_start=1 FT /transl_table=11 FT /locus_tag="MFS40622_1845" FT /product="DNA polymerase beta domain protein region" FT /note="PFAM: DNA polymerase beta domain protein region; FT KEGG: mvu:Metvu_0398 DNA polymerase beta domain protein FT region" FT /db_xref="EnsemblGenomes-Gn:MFS40622_1845" FT /db_xref="EnsemblGenomes-Tr:ADC70514" FT /db_xref="GOA:D3S8S3" FT /db_xref="InterPro:IPR002934" FT /db_xref="UniProtKB/TrEMBL:D3S8S3" FT /inference="protein motif:PFAM:PF01909" FT /protein_id="ADC70514.1" FT /translation="MNEKMLNKILNEFLNKCKEKFGDDLISIILFGSYARGTATEYSDI FT DLLIIVKNLPERRIDRYKIIKDIDLEFLKKYCIALSPILVKPEELSIKSINPLIYGILT FT GYRVIYDKNNFWKNYLEKIRPIIKRTNPIFVDGEKEWKIAELI" FT gene 9562..9735 FT /locus_tag="MFS40622_1846" FT CDS 9562..9735 FT /codon_start=1 FT /transl_table=11 FT /locus_tag="MFS40622_1846" FT /product="HEPN domain protein" FT /note="PFAM: HEPN domain protein; KEGG: mvu:Metvu_0399 FT hypothetical protein" FT /db_xref="EnsemblGenomes-Gn:MFS40622_1846" FT /db_xref="EnsemblGenomes-Tr:ADC70515" FT /db_xref="InterPro:IPR007842" FT /db_xref="UniProtKB/TrEMBL:D3S8S4" FT /inference="protein motif:PFAM:PF05168" FT /protein_id="ADC70515.1" FT /translation="MENRRVNLSKFFLSMAEEDLEIAKILLETNHHSGSVFHSQQCIEK FT AFRNCYILDRQI" FT gene 9748..10380 FT /locus_tag="MFS40622_1847" FT CDS 9748..10380 FT /codon_start=1 FT /transl_table=11 FT /locus_tag="MFS40622_1847" FT /product="DNA binding domain protein, excisionase family" FT /note="TIGRFAM: DNA binding domain protein, excisionase FT family; PFAM: Resolvase domain; regulatory protein MerR; FT KEGG: mja:MJ0014 hypothetical protein" FT /db_xref="EnsemblGenomes-Gn:MFS40622_1847" FT /db_xref="EnsemblGenomes-Tr:ADC70516" FT /db_xref="GOA:D3S8S5" FT /db_xref="InterPro:IPR006118" FT /db_xref="InterPro:IPR006119" FT /db_xref="InterPro:IPR009061" FT /db_xref="InterPro:IPR010093" FT /db_xref="InterPro:IPR036162" FT /db_xref="InterPro:IPR041657" FT /db_xref="InterPro:IPR041718" FT /db_xref="UniProtKB/TrEMBL:D3S8S5" FT /inference="protein motif:TFAM:TIGR01764" FT /protein_id="ADC70516.1" FT /translation="MERHYTLKEAAKILGVSIKTLQRWDKAGKIKCVRTVGGKRRVPES FT EIKRILGIKDDKQRKIIGYARVSSNTQKDDLERQIQLIKSYAEENGWKIQILKDIGSGL FT NEKRKNYKKLLKMVMNREVEKVIIAYPDRLTRFGFETLKEFFKSYGTEIVIINKRQKAL FT QEELVEDLITIVSHFAGKLYGMRSHKYKKLTKTVKEILREDNAKEEN" FT gene 10361..11671 FT /locus_tag="MFS40622_1848" FT CDS 10361..11671 FT /codon_start=1 FT /transl_table=11 FT /locus_tag="MFS40622_1848" FT /product="transposase, IS605 OrfB family" FT /note="TIGRFAM: transposase, IS605 OrfB family; PFAM: FT transposase IS605 OrfB; putative transposase FT IS891/IS1136/IS1341 family; KEGG: mfe:Mefer_0450 FT transposase, IS605 OrfB family" FT /db_xref="EnsemblGenomes-Gn:MFS40622_1848" FT /db_xref="EnsemblGenomes-Tr:ADC70517" FT /db_xref="InterPro:IPR010095" FT /db_xref="UniProtKB/TrEMBL:D3S8S6" FT /inference="protein motif:TFAM:TIGR01766" FT /protein_id="ADC70517.1" FT /translation="MPKRKTKLPTEIVLTYKVRHGYNLDNLPNEFIKIAQKAVDIIWEN FT INWKEKKVKHRYKVGRKYKYYTTIRLIPEIPKDKTFKRELRSILLKNWNFASHYVDGAI FT KVAYSTIESWKSNYLNGKRGRNKPIFKRPFVRVKTTLIKYDKENGLIRITIKPRKEYLT FT LNIKNEWFFDKVRDFTIGEVILKDKEALITFKKPLNLSDKRILIGVDSNLKSLDLYHPE FT KGWIRIDLSELHRIKKVYDAIIDKLKSIYKKAPKRIGKLLKKYLNRRKNRVNDFINKLT FT SQLSKLFPNAIFVFEDLDKFNMYDDNSSFNRSLDRSSWREIARRLEYKSIVFYVNPHYT FT SKTCPVCGSKMKSQEGQVVKCDKCGVFDRQFVGCFNVFKRGVELVKEFLGGVGVPVAGV FT KGDDLLPNEPRGELNPMPPNPNVVYYVDLNGKYLKCL" FT gene 11695..12006 FT /pseudo FT /locus_tag="MFS40622_1849" FT /product="hypothetical protein" FT gene 12010..12161 FT /pseudo FT /locus_tag="MFS40622_1850" FT /product="hypothetical protein" XX SQ Sequence 12197 BP; 4353 A; 1597 C; 2263 G; 3984 T; 0 other; aggataagtt agaaattttc gaagtgcatg ccactgtttt atagagggta tattgccgat 60 tttataaaaa ataggcagtc attttgtata ataactaatt aagggaacat gttaaagaaa 120 gataaaatgg aaatgaaaaa ttatatccaa tagttgaaat gttatccaaa gtaaaagagc 180 atatttgtag aaaaatatac tctgaacaaa aatatacttg catacttgta tattctgcta 240 cctttccagt gaagataaca aaagttatat tctatagttg ccataactat gagtagaaaa 300 atagaggttg gtagttatgg agttatctaa caatgatgtg ttttttattg ccatggggat 360 ttatttgttc ctattgtttg ctattgcatt tatgacttat agatgggcta agagtgtaaa 420 actatctaaa acataatttt aaccattttt tattagctta tttcctaaaa tccaaaatgt 480 aattattcct aatgttgcta tacaacataa tccaatggca atggcttttt tatacacaaa 540 taagttgtat gtgcttagca ataacccgta atagctatgt tcaattagta tgttaaatat 600 ttttctaaca acatagttgt agaattctat tctatcctct atgcttagtt gtttgtaaat 660 gtcaaagcca tagcctaata taaattggaa agcaaataat aagccaattc ctataattac 720 catgaatata atgcttatgt tagttggata ctgcaagggc tggaacatta taccaatagc 780 tataactaag taagtcataa gagttaattt tattatggaa attgtgttat ctataaaata 840 ggttatttta tcattcatag caacaccatt aggggcttta cctttctatt tttctatatt 900 tctaaaggca tgattaaatt gttttaaaag tatataaact attaagatat ctccaaagtt 960 cagtatgtgt gtttaagcaa tttttgctat tattatgtgt ggtggtgttg gtctttagcc 1020 tcaaaggcaa actttggtta aaaaattccg gacactaaaa atgtaagtta tttaacatac 1080 atatttggtg tttttatcat gccactgctt gattaagtgc aagatttttt agaagtttaa 1140 agttgattaa cccacccctc cttcgaacct attttaaaca aatgcaattc gttataaaaa 1200 accagtatga gggtaataag cagtgttaaa ataggaactg cttaaatttc attaatgaaa 1260 caaaatgtat tacaaaaaaa gaaaaccaat tcccaccctc caagaggtct tattttaact 1320 ttatagttcc agcattacaa aaatgttatc taaaaggttt ccatcctcca agaggtctga 1380 ttttaacaac aaatatttat atacagctac agctttgttt agggtaagtt tccatcctcc 1440 aagaggtctg attttaacac gattatagtg aagagttaga gagcttttta attgaagttt 1500 ccatcctcca agaggtctga ttttaactga taaggaaatt aaagaagtta cagacgatgt 1560 agttaggttt ccatcctcca agaggtctga ttttaacacg cagtaaatat ataccttagt 1620 agattaaaag aatagtttcc atcctccaag aggtctgatt ttaacgcagt tttacgatgt 1680 atttaatcaa aaggaattct agtttccatc ctctaagagg tctgatttta acccaaccaa 1740 tagaaaaaat aataaatgct gataagaggt ttccatcctc taagaggtct gattttaacc 1800 attttagaaa gttatttgtt aatatcatgt gttatgtttc catcctctaa gaggtctgat 1860 tttaacaggg caatcatcga caatatagtt ttaattacca ttcttatatt taagcttttt 1920 ggaaccatat ttttctaagt atagatgaca tcttttattt ataaatccaa cgctatataa 1980 gcttttttct tatatacaaa atagaggatt tttatatttc taaatttgaa gatttaactt 2040 attggttgga gaaattttat ttagcttatt atttaacctt aacttttaaa aatctaaatg 2100 atttaataaa cctaaatatt ccgaataatc aaactaccat atccttagaa attaaataaa 2160 aatcctctaa attagcaaat atcaaatagt tattaccttt attaaattca aagttcattc 2220 ggcgagacag ccacaacact acaataaaca actaaatcaa acaaataaaa atatcaaaaa 2280 acccatataa atatttttgt tctttttaaa ttattctttc taaatcatat tgtttaagtg 2340 caggttgaat ttttttgaac actatatcca aaacatgtag gcagtggcat agctattaat 2400 ccagatgcca ctgccaatat acaacaatct ataatttttt accatatttt tcttttaaaa 2460 actcattaaa tctctcctta tcctctaaaa caaataatag taaatctaca actaatttac 2520 taactgttat tttttcatac tttgagcaaa tatataaaaa atcatgcaaa ttttcaggaa 2580 aggaaatccc agcccttttt acccctccat tcatgccatt gttaatattg gctaaaaaat 2640 catcatagtg agctttaaca acgttatgaa tgctttgata attctctttt tctctataat 2700 cttctttttt gtcttttttg aacaaattca gcattaatta ccacctttta attattttat 2760 aaacagtggc atttaattca agtcagttag cacttctttg acagtttcca aagcagtttc 2820 ataatccaat ccacactcta ctaatgccat tgctatatcc tctggcttta aaacatccaa 2880 ttgatacttt tttatcaaat cccatcgacc ttctcttttt aaatgttgtt ttccctttga 2940 tttattctca tgccccaaat atttgtcaac ataagcccca gcttttttaa aggataagta 3000 aatcttcttt ttcaatggca tatttttgcc agcataaaca ttagtgtata tctccttcaa 3060 cttctctaaa aacaattctg aagctctcaa ttttctcaat ccatgaatat taaccccttt 3120 ttcaacataa tagtttaatc cgcagttttt taaacatctt ctaaaaaatg cattaacact 3180 atctttatcc aagcctacaa tttcaacatc atctaaaatg ttgtttttta tttgatgctc 3240 tttgattgat ttgagcaatt catactcttt ttcagtatga gcagggatta ctctatgtaa 3300 tccatgtttt gagtttttga caattaaata agcattatat attgatttcc caaccataaa 3360 acgctttaat gagtctggaa tagctctttc atctaaaaca acatctccat attttagttt 3420 tgcaatttca ttcactctca aagcaaaatg tcttgctaaa acaatgccaa tctttgcttt 3480 gctctttgat ttttggaaat actcactatt gataaccctt ttataatctt caggttctat 3540 ccttatggtt cttgcttctt gttgtagtgc atgctgagga acataaatcc cctttgcaaa 3600 tttaaaattc cattttagcc cataagtttt agcacaggct aaattcaatg ctttaatcat 3660 tgaaacatac ttttttaatg ttgttgctct aactccctct tttgctttgc attcgaggaa 3720 aagttgagtc atttcaggag ttatatcgca agctctttta actttaaatt cattttgtat 3780 ccatcttcca aagttatttg caaattttat taaggagtct aagtatccct ccttatgcct 3840 attcccacgc caaaaatccc cccttgaggc tacaaaccaa atttttgatt tttctttgag 3900 ccattcttcg aaggtaatgt ctcccctctc ataagctttg tctaattcct gccattgctg 3960 tttaaattgt cttctttgcc ctctatgcct ataggattgc atgactgcat actttagctg 4020 gtgatgtaaa ggcctattcc tacccattaa atcccaccaa attttaccac aattggttaa 4080 tataaatatt ttgtattcgc taaataaaca attataacaa tgtgtatttg taaaatgtgc 4140 ttacacactt tgtattaacc ttagtttctc ccaaattgtg ttgttttttg tggtgtgcat 4200 ggtttgtttg tttatattta tccatttgga ataaccaata atcgaggcag tcctaacccg 4260 tcgtgggtaa ttgccattac ccacgacggc taccgccctc aggaataaac aatgccccca 4320 atatatcgat taattcacat attgaaacat cctgctctcc acggatgtgg agagccgaaa 4380 ggttcctgga gggtcgccct ttatggcatg ggcagtcccc ctcccagccc ctcactctgc 4440 cacaccccca acggagtgtg ggtcatcggt catcggagct aatttattgg aataaactaa 4500 tattttgata tatagttgtt tcaatatata ctataacgac attttcatac atttgtgtat 4560 ttaaaatagt tctcctcctt gtccctcctt aacttctatt gcaccccacg tgattaattt 4620 aaaagaaaca ttatagtttc tgtaatagag agtatatata actatcgcat ccacaaaaaa 4680 caaaactgcc aattttttgg gaaaatcaag gaatcattag ccccattttc gggaaaaata 4740 ccaattaaat ctcaatttag aggtattagg gagagtatga ggaaaagaac tgttcagtat 4800 atgtgaaata acataattat ggtatatagt atattcggga caatgaggag ttttggagat 4860 ttgaggaatg tcaaggagtt attaccccta tttttcggag aataacgagg atttttgaga 4920 ttttaacaat ggttgtgttt attgtatgca caaccatcga aattggaaaa aatcataaaa 4980 tcataggggt tgaaaaactc aatttcttat ctggatggaa tatgccttat ctgttgagta 5040 ttgatagata tatacggata aaagtcttat ccgacagata agattagatt aaaacagata 5100 aggttcttat ctgttagata aaaacaattc caaacagata agaacggata agaatagata 5160 gagacagata agaacggata agaatagata aaacaggata aggttattac taaacagata 5220 aaggaatata agttgagata tatattttgg atatctggct atagtagtat gacttaatta 5280 tctctagcta cctttctgag ctaaagttcg gagctttgta atagatatag caaagtatat 5340 atatccaatg ttacaatata acaataaacc attaagttgt gattgttatg aagtattatt 5400 ctgccagaga agctgcaaaa atcttgggtg tagctcatac tactgtaatt cgatggattg 5460 aaaagggaga attgaaagct aacattagaa aaacgttata tagagtatat tatcagattc 5520 cagaggatga agtgttgaga ttaaaaaaaa ggctggaagc ccagcacgat taacatttgg 5580 gagtattgta cgattacgtt aggacacaag agtgttctaa tagagattca cagtggttta 5640 ttaaaaattt tgcacgatta cgtataggat atctaccaaa gttttaaggt gatgtgcatg 5700 tccccaaatg agtatattat tgataaaata tataatattt tcgaacgtga gaggaaaaag 5760 catcctacct ataaagaaag caaatatgat aaagaatcag aatataagga attaataaag 5820 tttttagtag aaaaagagga ggtaaatgaa gctgaattga tgctaaaggc aaaggaaata 5880 gggcttggaa ggttgtatta caacacattc attgcaatat taaaaaaata tcttaatttt 5940 attgatattg gagaagagga tggttataag gttattaaaa tcacaaatga attaagaaat 6000 gttttaaatg atgataatga aagtgatgaa tctaatttta aaatagatat ggaatttatc 6060 ataatgcaat atgaagactt gttaagaaaa tatttaaaga attatattac tgttgttggt 6120 cccgagaagt tggaaaggaa gattaggctt tctgcaaggg atttatctgc agagtttggg 6180 gatatgattg attatgccat tgagagtgtt gataattatt atcaggtagt tgattatttg 6240 acaaaattat ttaatgaggt atattatgag ataacttatg aaatgggaga ttttaaggtt 6300 gttttgtgtg attttccagc attggaaatt gatgttaata agattaatgc tgaatatgtt 6360 aataaggtag tagaatttga agcaaacata atttacgcgt ctcatgtttc tgtttttgtg 6420 aaaaagagtg ttttccaatg tccaagatgt ggaaaaatag ttaatgtgta tctcagggac 6480 ttttttgcaa aaaatagtga taagttggta tgtaatgagt gtaatgtaaa attacagcac 6540 attaaagacg aagaatacac aaactttcag gaattgattg ttcaggggct acctaacgag 6600 aaggggtata taagggagca gagagtgttg tatgaagact ctgacggggt ttttagtgga 6660 tatgtgaaga ttacaggtat cgtcaggaca gttccaagga gttcaaaatc caaagtttat 6720 gatttggttg ttcaggcagt ggatgttgag gagattgata acattgctcc aagattgaca 6780 aagaaggaca ttgaagatat taaaaagatt gctaagagga aggatgtcat tgatttatta 6840 tcagatagat taatcccaga gattaagggg cattcacttg taaaaaaagc tgttttctta 6900 caacaaatta ggggggtgaa aaaaccagga aaaagggata aaatcaacat tctcttaatt 6960 acagaccctg ggattgggaa gacggttatt ttaagaaaga ttgcggagat tccaggtaat 7020 aattatgtga gtatgccaac ttcaacgatt aacagtgttt ttgcaattgc agagaagaaa 7080 aagagcctat ctggagaaag ttggactgtg aaagttgggc ctgttccaaa gtcaattgga 7140 actgtatgta ttgatgaatt ctacattccc aaaggagata ctacatttta tgaggctatg 7200 gagggggatg taatccattt ttgtaaagga gggattgatg caaggttgca atcagtttgt 7260 agctttcttt gtgcgagaaa cccaagatgg ggaagattta atccggatgt ttctgtagct 7320 gaacagattg atatcccagc tccattgctt agcaggtttg acttgatttt cccaattagg 7380 gatagggcag ataaagaggc tgataaggaa attgcagaac acattataga tgtgcatagg 7440 gcttatttag acaaggaagt taataaaaag attagattag attacattaa gattgatgga 7500 gtgataattg actttgagtt cattgtaaaa tacattttct acgcaaggca gttaaaacca 7560 gttatgactg gggaaactaa gaaaaaatta gtaaattggt atgtagagat gaggaaaaaa 7620 cataacatca ctgcaagaca gttagaagcg gccgtaagat tggctgaagc tcatgcaaaa 7680 gcaaaattga aagatgttgt tgatgttgag gatgcagagg aggcaattgg aatgataaca 7740 gaatgtttaa aagagattgc ttatgaccca gaaactggaa tattcgatat tgacaaaata 7800 atgggagttc atagtagtga aaggaaaaag ttagatattg tgtataatgc catagaagag 7860 ctttcacatg ggagttcgga ggttttagtt ggttttgatg aaatcttaaa ttttgttgaa 7920 gaaaaaggaa taaatgagaa ggaattggaa agattgttaa acaagttgaa aaagtttgga 7980 gatattgatg aaccaaaacc gggaaggtat cggttgatat aatatataat ataatatata 8040 ttatatgttg tatctgctgg tggaggtgtt ggtatggcag tctcctatgc taggatatat 8100 gagttgttac ttaaatatgt taaggatgag aagaaggcta tggaatgtta tgatgtggtt 8160 gttgaggtaa taaaggagat tgagagagag gctagggaag gggttaaaga tgatttgagg 8220 gatgagttgg ctactaagaa ggatattgcc cttttggagg aaaaaatgaa ttctatggag 8280 gagaggattt taaggtatgt tgataataaa tttaatcaaa taaaaatatt gatactaatt 8340 accttatttg ctgtaattgt tttgaatcct tatgcttatg aaattgtaaa ggccatattg 8400 aaataatttt ttcattgagt gttggtgtta ttcaatgtta gaaaatgaat tagccactaa 8460 gaatgatatt gccctattgg aggagaggat gaattctatg gatgagaaga ttttaaggta 8520 tgtggataat aagttttatg aattggataa aaagactgat agaatctttt atttgattat 8580 tgtgttcatg atagtgtatg tattgacaaa tcctcaagtt gtgggagtta taaaattaat 8640 ttttatgaaa taatagaata agagggatat aatggatatt gacaaataca ttgaaaactt 8700 ggagataaag aaggagggat ttttctataa atgtccttat tgtgattata ctaatgcaga 8760 cttaaaagtt ataaaaaagc atattaaaac taagcattta gatgagataa agaaagaggt 8820 tgagaagatg aataaaccaa agcaaaagca gaataagcag aggaggatgc cacagaggaa 8880 gcaagtaaag aaggaggatg attataagga ttatttgttg ttatttgctc ataagaagaa 8940 gtgtaaaatc catttggaca atggcatggt tgttgagggc ttggttaagg caaaggataa 9000 gtataatatt atggttttag atgcgagggc tgatggcaag gatgttggta ggatgataat 9060 tcaaaagggg catattgttg ctctaattcc gttagaggaa taagtatggg aaaatagtag 9120 ttatgcaagg ggagggtcaa aaatgaatga aaaaatgtta aacaaaatcc taaatgaatt 9180 tttaaataaa tgtaaggaga aatttgggga tgacttaata tcaattattt tatttggttc 9240 ttatgcaaga ggaacagcta cagaatattc tgatattgat ttgttgatta ttgttaaaaa 9300 cctaccagaa aggagaattg ataggtataa aattataaaa gatattgatt tagagtttct 9360 taaaaaatat tgtatagcct tatctccaat cttggtaaag ccagaagaat tatcaattaa 9420 atcaataaat ccgttaatat atggaatttt aactggttat agagtaattt atgataaaaa 9480 taatttttgg aaaaattatc ttgaaaaaat aagaccaatt attaaaagaa caaatccaat 9540 atttgttgat ggggagaaag aatggaaaat cgcagagtta atttaagtaa gttttttcta 9600 tctatggcag aggaggattt ggaaatagca aaaattttat tggaaacaaa tcaccactct 9660 ggttctgtct ttcactctca acagtgtatt gaaaaagcct tccgaaactg ttatatatta 9720 gatagacaaa tatagacatt gatggttatg gagcgacatt atactctaaa agaagcggca 9780 aaaatcttag gagtttcaat taaaacatta caacgttggg ataaggcggg aaaaattaaa 9840 tgtgttagaa cggtaggagg taaaagaaga gttccagaga gtgaaataaa acgaatctta 9900 ggaataaaag atgacaaaca aaggaaaatt atcggatatg caagagtgtc atcaaacact 9960 caaaaagatg atttagagag gcaaatacaa ttaataaaat cctatgcaga ggaaaatggt 10020 tggaaaatac aaatattaaa agacattggt agtggtttaa acgaaaagag gaagaattat 10080 aaaaaacttt taaaaatggt tatgaatcgg gaggttgaaa aagtaataat cgcttatcca 10140 gacagattaa caagatttgg ttttgaaacg ttaaaagagt tttttaaatc ttatgggact 10200 gaaattgtaa ttataaacaa acgacagaag gcactacaag aagaattagt tgaagatttg 10260 ataacgattg tttcccactt tgcaggaaag ctttatggaa tgcgttctca caagtataaa 10320 aagcttacca aaacagttaa agaaatctta agggaggata atgccaaaga ggaaaactaa 10380 actcccaacg gaaattgtat taacttataa agttagacat ggttataact tagacaacct 10440 accgaatgaa tttataaaaa tagcccaaaa ggcagttgat attatttggg aaaacatcaa 10500 ctggaaggaa aagaaggtaa aacatcgata taaggtgggg agaaaatata aatattacac 10560 taccattcga ttaattccag agattccaaa ggataagact tttaaacggg agttaaggag 10620 tatcctacta aaaaattgga atttcgcatc acattatgtc gatggtgcta taaaagtagc 10680 ttactctaca atagaaagtt ggaagtcgaa ttatttgaat ggtaagaggg ggaggaataa 10740 gccaatattc aaaagacctt ttgttagggt taaaacaact ctaataaaat acgataaaga 10800 aaatgggctg ataagaatta caataaaacc gagaaaggaa tatttaactc taaatattaa 10860 aaatgaatgg tttttcgata aagttagaga tttcaccatt ggagaggtta ttttaaagga 10920 caaagaagca ttaataacat ttaaaaaacc attaaattta tccgataaga ggattttaat 10980 tggagttgat agtaatctaa aatcactcga tttatatcat cctgagaaag gttggattag 11040 gattgatttg tctgaattgc ataggataaa gaaggtttat gatgctataa ttgataagtt 11100 aaagtcaatc tataaaaaag ctccgaagag gattggcaaa ttattgaaaa aatatcttaa 11160 taggagaaaa aatcgagtta atgattttat taataaattg acttcacaac tgtcaaaact 11220 ctttccaaat gcaattttcg tttttgagga tttggataag tttaacatgt atgatgataa 11280 ttcgagtttt aataggagtt tggataggag tagttggagg gagattgcga gaaggttgga 11340 gtataagagt attgtttttt atgttaatcc tcattatact tcaaaaacct gtcccgtatg 11400 cgggagtaaa atgaagtccc aagagggaca ggttgttaag tgtgataagt gtggtgtttt 11460 tgatagacaa tttgttggtt gttttaacgt gtttaagagg ggtgttgaat tggttaaaga 11520 atttttaggc ggagttgggg ttcccgtggc tggggtgaag ggtgatgatt tactccccaa 11580 tgaacccaga ggggagttga acccaatgcc acccaatccc aacgtggtct attatgttga 11640 tttaaatgga aaatatctca aatgcctata attgtccata aatgaccacg ttgggaagac 11700 cccattaaat ctgtattaat tttatttgga gtttttataa aaacacatta tgtttcaacc 11760 ctgctggtaa ggaatttgga taacttcgat gaatattgga aaggaagatt tgaaagttta 11820 ttacctataa taagggagtt agaaagacat tgggctttgc cccgatatcc tgaaccaatg 11880 ggggaggatg tgtggaatcc actggagaaa tatacaaaag aggatgctga agaatgctta 11940 aaaaatgcag aggaagtttt aaaagttgtt aaagaatttt taaaagaaaa atataattta 12000 gagtaagagt ttaaagaaag ttatgaaatt gaagacataa caataaacaa aaaagttaga 12060 agttttcact taaacaaaat attttattct taaatccaca aaaagggatt ttaaaatctc 12120 aaagttattt gatttggaat gttatagaga ggttgttatg aagttgattc agagactgaa 12180 ctttaattcc aaagttc 12197 //