| Qualifier | pseudogene |
| Definition | indicates that this feature is a pseudogene of the element named by the feature key |
| Value Format | "TYPE" where TYPE is one of the following: processed, unprocessed, unitary, allelic, unknown |
| Example | /pseudogene="processed" /pseudogene="unprocessed" /pseudogene="unitary" /pseudogene="allelic" /pseudogene="unknown" |
| Comment | TYPE is a term taken from the INSDC controlled vocabulary for pseudogenes (http://www.insdc.org/documents/pseudogene-qualifier-vocabulary): processed: the pseudogene has arisen by reverse transcription of a mRNA into cDNA, followed by reintegration into the genome. Therefore, it has lost any intron/exon structure, and it might have a pseudo-polyA-tail. unprocessed: the pseudogene has arisen from a copy of the parent gene by duplication followed by accumulation of random mutations. The changes, compared to their functional homolog, include insertions, deletions, premature stop codons, frameshifts and a higher proportion of non-synonymous versus synonymous substitutions. unitary: the pseudogene has no parent. It is the original gene, which is functional is some species but disrupted in some way (indels, mutation, recombination) in another species or strain. allelic: a (unitary) pseudogene that is stable in the population but importantly it has a functional alternative allele also in the population. i.e., one strain may have the gene, another strain may have the pseudogene. MHC haplotypes have allelic pseudogenes. unknown: the submitter does not know the method of pseudogenisation. |