{"EMPIAR-14088":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame movies","directory":"data/movies","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":34997,"frames_per_image":50,"frame_range_min":null,"frame_range_max":null,"voxel_type":"32 BIT FLOAT","pixel_width":0.83,"pixel_height":0.83,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"","image_width":"5760","image_height":"4092"},{"segmentations":[],"name":"Aligned motion-corrected micrographs","directory":"data/motioncorrected","category":"micrographs - single frame","header_format":"MRC","data_format":"MRC","num_images_or_tilt_series":34997,"frames_per_image":1,"frame_range_min":null,"frame_range_max":null,"voxel_type":"16 BIT FLOAT","pixel_width":0.83,"pixel_height":0.83,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"","image_width":"5760","image_height":"4092"},{"segmentations":[],"name":"particle stack used to reconstruct the consensus map","directory":"data/stacks/consensus_particles","category":"picked particles - multiframe - processed","header_format":"MRCS","data_format":"MRCS","num_images_or_tilt_series":1155053,"frames_per_image":1,"frame_range_min":null,"frame_range_max":null,"voxel_type":"16 BIT FLOAT","pixel_width":1.0375,"pixel_height":1.0375,"micrographs_file_pattern":"","picked_particles_file_pattern":"data/stacks/consensus_particles/restacked_particles.cs","picked_particles_directory":"data/stacks/consensus_particles/restack","details":"Particles were imported from Relion into CryoSPARC for final reconstruction, map quality control analyses, and then restacked for export.","image_width":"256","image_height":"256"},{"segmentations":[],"name":"particle stack used to reconstruct the sublcass 2 map","directory":"data/stacks/subclass2_particles","category":"picked particles - multiframe - processed","header_format":"MRCS","data_format":"MRCS","num_images_or_tilt_series":98137,"frames_per_image":1,"frame_range_min":null,"frame_range_max":null,"voxel_type":"16 BIT FLOAT","pixel_width":1.0375,"pixel_height":1.0375,"micrographs_file_pattern":"","picked_particles_file_pattern":"data/stacks/subclass2_particles/restacked_particles.cs","picked_particles_directory":"data/stacks/subclass2_particles/restack","details":"Particles were imported from Relion into CryoSPARC for final reconstruction, map quality control analyses, and then restacked for export.","image_width":"256","image_height":"256"},{"segmentations":[],"name":"particle stack used to reconstruct the sublcass 7 map","directory":"data/stacks/subclass7_particles","category":"picked particles - multiframe - processed","header_format":"MRCS","data_format":"MRCS","num_images_or_tilt_series":97830,"frames_per_image":1,"frame_range_min":null,"frame_range_max":null,"voxel_type":"16 BIT FLOAT","pixel_width":1.0375,"pixel_height":1.0375,"micrographs_file_pattern":"","picked_particles_file_pattern":"data/stacks/subclass7_particles/restacked_particles.cs","picked_particles_directory":"data/stacks/subclass7_particles/restack","details":"Particles were imported from Relion into CryoSPARC for final reconstruction, map quality control analyses, and then restacked for export.","image_width":"256","image_height":"256"}],"workflow_file":null,"grant_references":[{"funding_body":"National Institutes of Health (NIH)","code":"GM148049","country":"United States"},{"funding_body":"National Institutes of Health (NIH)","code":"GM159035","country":"United States"},{"funding_body":"National Institutes of Health (NIH)","code":"AI136680","country":"United States"},{"funding_body":"National Institutes of Health (NIH)","code":"AI170855","country":"United States"},{"funding_body":"National Institutes of Health (NIH)","code":"GM151305","country":"United States"},{"funding_body":"National Institutes of Health (NIH)","code":"AI196844","country":"United States"},{"funding_body":"National Institutes of Health (NIH)","code":"GM146435","country":"United States"},{"funding_body":"Alfred P. Sloan Foundation","code":"25294","country":"United States"}],"version_history":[],"title":"Cryogenic electron microscopy movies of the 85h34 polymerase ribozyme replication complex","principal_investigator":[{"author_orcid":"0000-0002-8124-7472","middle_name":null,"organization":"The Salk Institute","street":"10010 N Torrey Pines RD","town_or_city":"La Jolla","state_or_province":"California","post_or_zip":"92037","telephone":null,"fax":null,"first_name":"Dmitry","last_name":"Lyumkis","email":"dlyumkis [at] salk.edu","country":"United States","entry":"EMPIAR-14088"},{"author_orcid":"0000-0003-0603-2874","middle_name":"F","organization":"The Salk Institute","street":"10010 N Torrey Pines RD","town_or_city":"La Jolla","state_or_province":"California","post_or_zip":"92037","telephone":null,"fax":null,"first_name":"Gerald","last_name":"Joyce","email":"gjoyce [at] salk.edu","country":"United States","entry":"EMPIAR-14088"}],"status":"REL","deposition_date":"2026-10-23","release_date":"2026-11-06","obsolete_date":null,"update_date":"2026-11-06","corresponding_author":{"author":{"author_orcid":"0000-0002-8124-7472","middle_name":null,"organization":"The Salk Institute","street":"10010 N Torrey Pines RD","town_or_city":"La Jolla","state_or_province":"California","post_or_zip":"92037","first_name":"Dmitry","last_name":"Lyumkis","country":"United States"}},"authors":[{"author":{"name":"Strutzenberg TS","author_orcid":"0000-0003-0598-534X"}},{"author":{"name":"Horning DP","author_orcid":"0000-0003-3357-6092"}},{"author":{"name":"Cochrane WG","author_orcid":"0000-0002-3325-6921"}},{"author":{"name":"Andrade L","author_orcid":"0000-0002-0004-5677"}},{"author":{"name":"Han X","author_orcid":null}},{"author":{"name":"Joyce GF","author_orcid":"0000-0003-0603-2874"}},{"author":{"name":"Lyumkis D","author_orcid":"0000-0002-8124-7472"}}],"cross_references":["EMD-78851"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Strutzenberg TS","author_orcid":"0000-0003-0598-534X"},{"name":"Horning DP","author_orcid":"0000-0003-3357-6092"},{"name":"Cochrane WG","author_orcid":"0000-0002-3325-6921"},{"name":"Andrade L","author_orcid":"0000-0002-0004-5677"},{"name":"Han X","author_orcid":null},{"name":"Joyce GF","author_orcid":"0000-0003-0603-2874"},{"name":"Lyumkis D","author_orcid":"0000-0002-8124-7472"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Structure of an RNA polymerase ribozyme replication complex","volume":null,"country":"","first_page":null,"last_page":null,"year":"2026","language":null,"doi":"10.64898/2026.08.30.748161","pubmedid":null,"details":"34,997 movies are recorded on a K3 detector (Gatan) with 50 frames with dimensions of 4092 by 5760 pixels and a pixel size of 0.83 angstrom.","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"bioRxiv","journal_abbreviation":"","issue":null,"preprint":true}],"dataset_size":"11.3 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["38jc"],"entry_doi":"10.6019/EMPIAR-14088"}}