{"EMPIAR-13770":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame micrographs of rabbit RyR1-FKBP12.6-CaM complex in the presence of dantrolene and Mg2+","directory":"data/movies","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":3954,"frames_per_image":50,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":0.8275,"pixel_height":0.8275,"micrographs_file_pattern":"data/movies/*.tif","picked_particles_file_pattern":"data/particles/RyR1_DanMg_particles.star","picked_particles_directory":"data/particles","details":"Please use data/movies/gain_reference_RyR1_DanMg.mrc with a Y-flip when importing into CryoSPARC. Particle images are located in data/particles. Particle positions, CTF estimations, and 3D alignments are described in the data/particles/RyR1_DanMg_particles.star text file. The exposure groups for individual exposures are logged in this .star file.","image_width":"5760","image_height":"4092"}],"workflow_file":null,"grant_references":[{"funding_body":"National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS)","code":"R01AR077720","country":"United States"}],"version_history":[],"title":"Rabbit ryanodine receptor type 1 complexed with FKBP12.6 and calmodulin in the presence of dantrolene and Mg2+","principal_investigator":[{"author_orcid":"0000-0003-1876-196X","middle_name":"Biggs","organization":"Department of Anesthesiology, Columbia University Irving Medical Center","street":"1150 St Nicholas Ave","town_or_city":"New York","state_or_province":"NY","post_or_zip":"10032","telephone":null,"fax":null,"first_name":"Oliver","last_name":"Clarke","email":"oc2188 [at] cumc.columbia.edu","country":"United States","entry":"EMPIAR-13770"}],"status":"REL","deposition_date":"2026-07-08","release_date":"2026-10-07","obsolete_date":null,"update_date":"2026-10-07","corresponding_author":{"author":{"author_orcid":"0000-0003-1876-196X","middle_name":"Biggs","organization":"Department of Anesthesiology, Columbia University Irving Medical Center","street":"1150 St Nicholas Ave","town_or_city":"New York","state_or_province":"NY","post_or_zip":"10032","first_name":"Oliver","last_name":"Clarke","country":"United States"}},"authors":[{"author":{"name":"Kim K","author_orcid":"0000-0001-9915-0145"}},{"author":{"name":"Clarke OB","author_orcid":"0000-0003-1876-196X"}}],"cross_references":["EMD-74357","EMD-74356"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Kim K","author_orcid":"0000-0001-9915-0145"},{"name":"Li H","author_orcid":"0000-0001-6518-8591"},{"name":"Yuan Q","author_orcid":null},{"name":"Melville Z","author_orcid":"0000-0001-8962-2612"},{"name":"Zalk R","author_orcid":"0000-0003-4251-6497"},{"name":"des Georges A","author_orcid":"0000-0002-9704-3781"},{"name":"Frank J","author_orcid":"0000-0001-5449-6943"},{"name":"Hendrickson WA","author_orcid":"0000-0003-1412-5747"},{"name":"Marks AR","author_orcid":"0000-0002-8057-1502"},{"name":"Clarke OB","author_orcid":"0000-0003-1876-196X"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene","volume":null,"country":"United States","first_page":null,"last_page":null,"year":"2024","language":"English","doi":"10.1101/2024.10.21.619409","pubmedid":null,"details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"bioRxiv","journal_abbreviation":"","issue":null,"preprint":true}],"dataset_size":"868.8 GB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["9zk9"],"entry_doi":"10.6019/EMPIAR-13770"}}