{"EMPIAR-13598":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame micrographs of  the C. elegans EGFR (LET-23) extracellular region with a domain IV loop deletion (part 1 of 4)","directory":"data/raw_movies/0711","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":5176,"frames_per_image":40,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":0.825,"pixel_height":0.825,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"","image_width":"5760","image_height":"4092"},{"segmentations":[],"name":"Unaligned multi-frame micrographs of  the C. elegans EGFR (LET-23) extracellular region with a domain IV loop deletion (part 2 of 4)","directory":"data/raw_movies/0712","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":11060,"frames_per_image":40,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":0.825,"pixel_height":0.825,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"","image_width":"5760","image_height":"4092"},{"segmentations":[],"name":"Unaligned multi-frame micrographs of  the C. elegans EGFR (LET-23) extracellular region with a domain IV loop deletion (part 3 of 4)","directory":"data/raw_movies/0713","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":10852,"frames_per_image":40,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":0.825,"pixel_height":0.825,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"","image_width":"5760","image_height":"4092"},{"segmentations":[],"name":"Unaligned multi-frame micrographs of  the C. elegans EGFR (LET-23) extracellular region with a domain IV loop deletion (part 4 of 4)","directory":"data/raw_movies/0714","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":4361,"frames_per_image":40,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":0.825,"pixel_height":0.825,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"","image_width":"5760","image_height":"4092"},{"segmentations":[],"name":"Gain reference for K3 movies","directory":"data/gain_reference","category":"micrographs - single frame","header_format":"MRC","data_format":"MRC","num_images_or_tilt_series":1,"frames_per_image":1,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":0.825,"pixel_height":0.825,"micrographs_file_pattern":"data/gain_reference/Gain*mrc","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Gain reference used for normalization of raw K3 movies. Orientation: no rotation, Flip upsidedown for motion import in RELION; no rotation, no flip in CryoSPARC","image_width":"5760","image_height":"4092"}],"workflow_file":null,"grant_references":[{"funding_body":"National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)","code":"GM149406","country":"United States"}],"version_history":[],"title":"Cryo-EM structure of a weak dimer of the C. elegans EGFR (LET-23) extracellular region with a domain IV loop deletion","principal_investigator":[{"author_orcid":"0000-0002-7671-5403","middle_name":"M","organization":"Department of Pharmacology/Cancer Biology Institute, Yale University","street":null,"town_or_city":"West Haven","state_or_province":"Connecticut","post_or_zip":"06516","telephone":null,"fax":null,"first_name":"Kathryn","last_name":"Ferguson","email":"kathryn.ferguson [at] yale.edu","country":"United States","entry":"EMPIAR-13598"}],"status":"REL","deposition_date":"2026-05-26","release_date":"2026-09-03","obsolete_date":null,"update_date":"2026-09-03","corresponding_author":{"author":{"author_orcid":"0000-0002-7671-5403","middle_name":"M","organization":"Department of Pharmacology/Cancer Biology Institute","street":null,"town_or_city":"West Haven","state_or_province":"Connecticut","post_or_zip":"06516","first_name":"Kathryn","last_name":"Ferguson","country":"United States"}},"authors":[{"author":{"name":"Zuo Y","author_orcid":"0000-0003-1810-4580"}},{"author":{"name":"Walker K","author_orcid":null}},{"author":{"name":"Han L","author_orcid":"0000-0001-6142-8412"}},{"author":{"name":"Ferguson KM","author_orcid":"0000-0002-7671-5403"}}],"cross_references":["EMD-73278"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Zuo Y","author_orcid":"0000-0003-1810-4580"},{"name":"Schwartz HT","author_orcid":"0000-0002-3448-8652"},{"name":"Walker K","author_orcid":"0000-0003-0603-5792"},{"name":"Han L","author_orcid":"0000-0001-6142-8412"},{"name":"Sternberg PW","author_orcid":"0000-0002-7699-0173"},{"name":"Ferguson KM","author_orcid":"0000-0002-7671-5403"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Ligand regulation and function of preformed EGFR dimers","volume":"123","country":"","first_page":null,"last_page":null,"year":"2026","language":"English","doi":"10.1073/pnas.2602436123","pubmedid":"42475585","details":"The micrographs are the average, without any realignment, of 40 raw movie frames (accumulating 50 electrons per squared Angstrom in a 2.3 second exposure)","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Proceedings of the National Academy of Sciences of the United States of America","journal_abbreviation":"Proc Natl Acad Sci U S A","issue":"30","preprint":false}],"dataset_size":"5.6 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["9you"],"entry_doi":"10.6019/EMPIAR-13598"}}