{"EMPIAR-13498":{"imagesets":[{"segmentations":[],"name":"Filament of D-TLKIVWI, a D-peptide that disaggregates Alzheimer s Paired Helical Filaments","directory":"data","category":"micrographs - multiframe","header_format":"EER","data_format":"EER","num_images_or_tilt_series":13364,"frames_per_image":2223,"frame_range_min":1,"frame_range_max":2214,"voxel_type":"UNSIGNED BYTE","pixel_width":0.94,"pixel_height":0.94,"micrographs_file_pattern":"data/2205-2*.eer","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Totally 2223 raw frames in EER format. Used first 2214 frames in 41 groups of 54 raw frames each. Dosage per group is 1.22 e-/A2.","image_width":"4096","image_height":"4096"}],"workflow_file":null,"grant_references":[{"funding_body":"National Institutes of Health (NIH)","code":"1R01AG070895","country":"United States"},{"funding_body":"National Institutes of Health (NIH)","code":"RF1AG065407","country":"United States"}],"version_history":[],"title":"Filament of D-TLKIVWI, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments","principal_investigator":[{"author_orcid":"0000-0003-2432-5419","middle_name":"S","organization":"Department of Chemistry and Biochemistry, and Department of Biological Chemistry, UCLA; HHMI","street":null,"town_or_city":"Los Angeles","state_or_province":"California","post_or_zip":"90095","telephone":null,"fax":null,"first_name":"David","last_name":"Eisenberg","email":"david [at] mbi.ucla.edu","country":"United States","entry":"EMPIAR-13498"}],"status":"REL","deposition_date":"2026-04-16","release_date":"2026-04-26","obsolete_date":null,"update_date":"2026-04-26","corresponding_author":{"author":{"author_orcid":"0000-0002-2661-8226","middle_name":null,"organization":"Department of Biological Chemistry, UCLA","street":null,"town_or_city":"Los Angeles","state_or_province":"California","post_or_zip":"90095","first_name":"Peng","last_name":"Ge","country":"United States"}},"authors":[{"author":{"name":"Hou K","author_orcid":"0000-0003-3869-2076"}},{"author":{"name":"Ge P","author_orcid":"0000-0002-2661-8226"}},{"author":{"name":"Sawaya MR","author_orcid":"0000-0003-0874-9043"}},{"author":{"name":"Lutter L","author_orcid":null}},{"author":{"name":"Dolinsky JL","author_orcid":"0000-0002-8042-9645"}},{"author":{"name":"Yang Y","author_orcid":"0000-0002-9538-6369"}},{"author":{"name":"Jiang YX","author_orcid":"0000-0003-1433-4952"}},{"author":{"name":"Boyer DR","author_orcid":"0000-0002-4487-0230"}},{"author":{"name":"Cheng X","author_orcid":"0000-0003-1654-4363"}},{"author":{"name":"Pi J","author_orcid":"0009-0000-9956-6351"}},{"author":{"name":"Zhang J","author_orcid":null}},{"author":{"name":"Lu J","author_orcid":null}},{"author":{"name":"Abskharon R","author_orcid":null}},{"author":{"name":"Yang S","author_orcid":"0000-0002-9794-7537"}},{"author":{"name":"Yu Z","author_orcid":"0000-0002-7114-2570"}},{"author":{"name":"Feigon J","author_orcid":"0000-0003-3376-435X"}},{"author":{"name":"Eisenberg DS","author_orcid":"0000-0003-2432-5419"}}],"cross_references":["EMD-44181"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Hou K","author_orcid":"0000-0003-3869-2076"},{"name":"Ge P","author_orcid":"0000-0002-2661-8226"},{"name":"Sawaya MR","author_orcid":"0000-0003-0874-9043"},{"name":"Lutter L","author_orcid":null},{"name":"Dolinsky JL","author_orcid":"0000-0002-8042-9645"},{"name":"Yang Y","author_orcid":"0000-0002-9538-6369"},{"name":"Jiang YX","author_orcid":"0000-0003-1433-4952"},{"name":"Boyer DR","author_orcid":"0000-0002-4487-0230"},{"name":"Cheng X","author_orcid":"0000-0003-1654-4363"},{"name":"Pi J","author_orcid":"0009-0000-9956-6351"},{"name":"Zhang J","author_orcid":null},{"name":"Lu J","author_orcid":null},{"name":"Abskharon R","author_orcid":null},{"name":"Yang S","author_orcid":"0000-0002-9794-7537"},{"name":"Yu Z","author_orcid":"0000-0002-7114-2570"},{"name":"Feigon J","author_orcid":"0000-0003-3376-435X"},{"name":"Eisenberg DS","author_orcid":"0000-0003-2432-5419"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"How short peptides disassemble tau fibrils in Alzheimer's disease","volume":"644","country":"","first_page":"1020","last_page":"1027","year":"2025","language":"English","doi":"10.1038/s41586-025-09244-z","pubmedid":"40634605","details":"Raw EER movies. Total dosage is 50 e/A2. Gain reference provided.","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Nature","journal_abbreviation":"Nature","issue":"8078","preprint":false}],"dataset_size":"8.6 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["9b4i"],"entry_doi":"10.6019/EMPIAR-13498"}}