{"EMPIAR-13274":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame micrographs of human cytomegalovirus protease in complex with an inhibitory antibody fragment","directory":"data/movies","category":"micrographs - multiframe","header_format":"EER","data_format":"EER","num_images_or_tilt_series":16378,"frames_per_image":1096,"frame_range_min":null,"frame_range_max":null,"voxel_type":"32 BIT FLOAT","pixel_width":0.743,"pixel_height":0.743,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"There are movies from 2 different grids in this dataset that were collected in a single krios session. In MZJ_1, the grids are Quantifoil 1.2/1.3 400 mesh copper foil grids, and MZJ_3 are UltrAUfoil 1.2/1.3 300 mesh grids. The MZJ_3 dataset tends to yield better particles, and our final reconstructions were comprised of about 80 percent particles from MZJ_3.","image_width":null,"image_height":null},{"segmentations":[],"name":"Unclassified particles of human cytomegalovirus protease bound to an inhibitory antibody fragment","directory":"data/All_particles_unsorted","category":"picked particles - single frame - processed","header_format":"MRC","data_format":"MRC","num_images_or_tilt_series":1455383,"frames_per_image":1,"frame_range_min":null,"frame_range_max":null,"voxel_type":"32 BIT FLOAT","pixel_width":null,"pixel_height":null,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"All particles used in final reconstructions. Upon classification, at least 3 poses of the protease relative to the Fab can be resolved.","image_width":null,"image_height":null}],"workflow_file":null,"grant_references":[{"funding_body":"National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)","code":"U54AI170792","country":"United States"}],"version_history":[],"title":"Single-particle Cryo Electron Microscopy of Human Cytomegalovirus Protease Bound to an Inhibitory Antibody Fragment","principal_investigator":[{"author_orcid":"0000-0001-7704-9185","middle_name":"S","organization":"Department of Pharmaceutical Chemistry, University of California San Francisco","street":null,"town_or_city":"San Francisco","state_or_province":"CA","post_or_zip":"94158","telephone":null,"fax":null,"first_name":"Charles","last_name":"Craik","email":"charles.craik [at] ucsf.edu","country":"United States","entry":"EMPIAR-13274"},{"author_orcid":"0000-0001-9535-0369","middle_name":null,"organization":"Department of Biochemistry and Biophysics, University of California San Francisco","street":null,"town_or_city":"San Francisco","state_or_province":"CA","post_or_zip":"94158","telephone":null,"fax":null,"first_name":"Yifan","last_name":"Cheng","email":"yifan.cheng [at] ucsf.edu","country":"United States","entry":"EMPIAR-13274"}],"status":"REL","deposition_date":"2026-01-28","release_date":"2026-07-12","obsolete_date":null,"update_date":"2026-07-12","corresponding_author":{"author":{"author_orcid":"0000-0003-1981-1244","middle_name":null,"organization":"Department of Biochemistry and Biophysics, University of California San Francisco","street":null,"town_or_city":"San Francisco","state_or_province":"CA","post_or_zip":"94158","first_name":"Marcell","last_name":"Zimanyi","country":"United States"}},"authors":[{"author":{"name":"Zimanyi M","author_orcid":"0000-0003-1981-1244"}},{"author":{"name":"Hulce KR","author_orcid":"0000-0001-8323-562X"}},{"author":{"name":"Bohn M","author_orcid":"0000-0002-0369-1922"}},{"author":{"name":"Norman J","author_orcid":"0009-0008-7524-3310"}},{"author":{"name":"Rohweder PJ","author_orcid":"0000-0002-3194-689X"}},{"author":{"name":"Cheng Y","author_orcid":"0000-0001-9535-0369"}},{"author":{"name":"Craik CS","author_orcid":"0000-0001-7704-9185"}},{"author":{"name":"Detomasi TC","author_orcid":"0000-0003-4390-108X"}}],"cross_references":["EMD-72659","EMD-72660","EMD-72658"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Zimanyi M","author_orcid":"0000-0003-1981-1244"},{"name":"Hulce KR","author_orcid":"0000-0001-8323-562X"},{"name":"Bohn M","author_orcid":"0000-0002-0369-1922"},{"name":"Norman J","author_orcid":"0009-0008-7524-3310"},{"name":"Rohweder PJ","author_orcid":"0000-0002-3194-689X"},{"name":"Cheng Y","author_orcid":"0000-0001-9535-0369"},{"name":"Craik CS","author_orcid":"0000-0001-7704-9185"},{"name":"Detomasi TC","author_orcid":"0000-0003-4390-108X"}],"editors":[],"published":false,"j_or_nj_citation":true,"title":"Antibody Reveals Conformational Latch Controlling Herpesvirus Proteases","volume":null,"country":"","first_page":null,"last_page":null,"year":null,"language":null,"doi":"10.1101/2025.10.17.683123","pubmedid":null,"details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"bioRxiv","journal_abbreviation":"","issue":null,"preprint":true}],"dataset_size":"7.4 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["9y7m","9y7n","9y7l"],"entry_doi":"10.6019/EMPIAR-13274"}}