{"EMPIAR-13078":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame micrographs from tilt series of HIV-1 cores, associated mdoc files, and gain reference","directory":"data","category":"tilt series","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":14,"frames_per_image":6,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":1.56,"pixel_height":1.56,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Each tilt image is comprised of 6 unaligned raw movie frames in TIFF format without gain correction. Gain reference is supplied as a separate file. Dose per tilt image is 2.54 e/A2 and total dose for each tilt series is 104 e/A2. Tilt azimuth is is 95 degrees.","image_width":"4096","image_height":"4096"}],"workflow_file":null,"grant_references":[{"funding_body":"National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)","code":"U54AI170791","country":"United Kingdom"},{"funding_body":"Wellcome Trust","code":"CC2058","country":"United Kingdom"},{"funding_body":"Medical Research Council (MRC, United Kingdom)","code":"CC2058","country":"United Kingdom"},{"funding_body":"Cancer Research UK","code":"CC2058","country":"United Kingdom"}],"version_history":[],"title":"Cryo electron tomography of HIV-1 cores isolated by sedimentation through sucrose gradient","principal_investigator":[{"author_orcid":"0000-0002-0634-538X","middle_name":null,"organization":"The Francis Crick Institute","street":"1 Midland Road","town_or_city":"London","state_or_province":"London","post_or_zip":"NW1 1AT","telephone":"07828073569","fax":null,"first_name":"Peter","last_name":"Cherepanov","email":"peter.p.cherepanov [at] gmail.com","country":"United Kingdom","entry":"EMPIAR-13078"}],"status":"REL","deposition_date":"2025-10-10","release_date":"2025-12-12","obsolete_date":null,"update_date":"2025-12-12","corresponding_author":{"author":{"author_orcid":"0000-0002-0634-538X","middle_name":null,"organization":"The Francis Crick Institute","street":"1 Midland Road","town_or_city":"London","state_or_province":"London","post_or_zip":"NW1 1AT","first_name":"Peter","last_name":"Cherepanov","country":"United Kingdom"}},"authors":[{"author":{"name":"Nans A","author_orcid":"0000-0002-3791-2447"}},{"author":{"name":"Chenavier F","author_orcid":"0000-0002-9486-3944"}},{"author":{"name":"Hope J","author_orcid":"0000-0003-2742-5538"}},{"author":{"name":"Zhang P","author_orcid":"0000-0003-1803-691X"}},{"author":{"name":"Cherepanov P","author_orcid":"0000-0002-0634-538X"}}],"cross_references":["EMD-55409"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Singer RM","author_orcid":"0000-0002-5498-4469"},{"name":"Zhen L","author_orcid":null},{"name":"Rey SJ","author_orcid":"0000-0003-2274-3748"},{"name":"Hope J","author_orcid":"0000-0003-2742-5538"},{"name":"Chenavier F","author_orcid":"0000-0002-9486-3944"},{"name":"Cook JN","author_orcid":"0000-0002-2738-7976"},{"name":"Punch E","author_orcid":"0000-0002-5477-6619"},{"name":"Smith J","author_orcid":"0009-0002-4515-9499"},{"name":"Zhou Z","author_orcid":"0009-0003-1329-5311"},{"name":"Maslen S","author_orcid":"0000-0002-0261-2866"},{"name":"Masino L","author_orcid":"0000-0002-5326-7003"},{"name":"Nans A","author_orcid":"0000-0002-3791-2447"},{"name":"Skehel M","author_orcid":"0000-0002-2432-0901"},{"name":"Taylor AI","author_orcid":"0000-0002-6763-3852"},{"name":"Zanetti G","author_orcid":"0000-0003-1905-0342"},{"name":"Zhang P","author_orcid":"0000-0003-1803-691X"},{"name":"Perilla RJ","author_orcid":"0000-0003-1171-6816"},{"name":"Engelman NA","author_orcid":"0000-0002-9709-2591"},{"name":"Cherepanov P","author_orcid":"0000-0002-0634-538X"}],"editors":[{"name":"Nans A","author_orcid":"0000-0002-3791-2447"}],"published":false,"j_or_nj_citation":true,"title":"Structural bases for integrase-RNA binding and retention of viral RNA within HIV-1 capsid cores","volume":null,"country":"","first_page":null,"last_page":null,"year":null,"language":"English","doi":null,"pubmedid":null,"details":"The data represent 14 tilt series, each from −60° to +60° with 3° increments, recorded using Krios G2 microscope with Falcon 4i detector and a Selectris energy filter. The data was acquired using the dose-symmetric scheme, a total exposure of 104 e/Å2 (2.5 e/Å2 per tilt), a calibrated magnification resulting in a pixel size of 1.56 Å, and a defocus range of -2.5 to -5.5 µm. Each tilt micrograph movie contains 6 frames in TIFF format. The calibrated tilt axis is 95 degrees.","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"","journal_abbreviation":"","issue":null,"preprint":false}],"dataset_size":"11.0 GB","experiment_type":"EMDB","scale":"virus","entry_doi":"10.6019/EMPIAR-13078"}}