{"EMPIAR-12890":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame micrographs (EER), pre-selected manually for the presence of twisting fibrils.","directory":"data/micrographs/multiframe","category":"micrographs - multiframe","header_format":"TIFF","data_format":"EER","num_images_or_tilt_series":41,"frames_per_image":936,"frame_range_min":null,"frame_range_max":null,"voxel_type":"SIGNED BYTE","pixel_width":null,"pixel_height":null,"micrographs_file_pattern":"data/micrographs/multiframe/FoilHole_*_Data_*_EER.eer","picked_particles_file_pattern":"","picked_particles_directory":"","details":"","image_width":"16384","image_height":"16384"},{"segmentations":[],"name":"Motion-corrected micrographs (MRC), pre-selected manually for the presence of twisting fibrils.","directory":"data/micrographs/singleframe/Images-Disc1-MotionCorr","category":"micrographs - single frame","header_format":"MRC","data_format":"MRC","num_images_or_tilt_series":40,"frames_per_image":1,"frame_range_min":null,"frame_range_max":null,"voxel_type":"16 BIT FLOAT","pixel_width":0.732,"pixel_height":0.732,"micrographs_file_pattern":"data/micrographs/singleframe/Images-Disc1-MotionCorr/FoilHole_*_Data_*_EER.mrc","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Micrographs which were used for particle picking in RELION, motion-corrected using RELION's own implementation of MOTIONCOR. Five files are listed for each micrograph: (1) the aligned MRC, (2) the micrograph power spectrum used for CTF correction (\"_PS.mrc\"), (3) the shifts used in motion correction (\"_shifts.eps\"), (4) the shifts and header in .star format (\".star\") and (5) the log file of the motion correction.","image_width":"4096","image_height":"4096"},{"segmentations":[],"name":"Extracted particles of manually picked fibrils (box size 800, binning 2, inter-box distance of 14.4A).","directory":"data/particles/Images-Disc1-Extract","category":"picked particles - single frame - unprocessed","header_format":"MRCS","data_format":"MRCS","num_images_or_tilt_series":40,"frames_per_image":1,"frame_range_min":null,"frame_range_max":null,"voxel_type":"16 BIT FLOAT","pixel_width":1.464,"pixel_height":1.464,"micrographs_file_pattern":"data/particles/Images-Disc1-Extract/FoilHole_*_Data_*_EER.mrcs","picked_particles_file_pattern":"data/particles/particles.star","picked_particles_directory":"data/particles/Images-Disc1-Extract/","details":"Extracted particles of manually picked fibrils (box size 800, binning 2, inter-box distance of 14.4A), before purification by a series of 2D classification and selection. Two files are listed for each micrograph: (1) the mrcs file with dimensions (N,400,400) where N is the number of particles extracted from that micrograph, and (2) the star file listing the coordinates of each particle (\"_extract.star\").","image_width":"400","image_height":"400"}],"workflow_file":null,"grant_references":[{"funding_body":"Swiss National Science Foundation","code":"IC00I0L-231578","country":"Switzerland"},{"funding_body":"Agence Nationale de la Recherche (ANR)","code":"ANR-24-CE93-0003","country":"France"}],"version_history":[],"title":"Structure of in-vivo formed alpha-synuclein fibrils purified from a M83+/- mouse brain injected with recombinant 1B fibrils","principal_investigator":[{"author_orcid":"0000-0002-1185-4592","middle_name":null,"organization":"School of Basic Sciences, Institute of Physics, Laboratory of Biological Electron Microscopy, Swiss Federal Institute of Technology (EPFL)","street":"Rte de la Sorge","town_or_city":"Lausanne","state_or_province":"Vaud","post_or_zip":"1015","telephone":null,"fax":null,"first_name":"Henning","last_name":"Stahlberg","email":"henning.stahlberg [at] epfl.ch","country":"Switzerland","entry":"EMPIAR-12890"},{"author_orcid":"0000-0001-8184-5248","middle_name":null,"organization":"CNRS, Institut des Maladies Neurodégénératives, Université Bordeaux","street":"146 Rue Léo Saignat","town_or_city":"Bordeaux","state_or_province":null,"post_or_zip":"F-33000","telephone":null,"fax":null,"first_name":"François","last_name":"Ichas","email":"francois.ichas [at] inserm.fr","country":"France","entry":"EMPIAR-12890"}],"status":"REL","deposition_date":"2025-07-15","release_date":"2025-08-04","obsolete_date":null,"update_date":"2025-08-04","corresponding_author":{"author":{"author_orcid":"0000-0001-9168-8450","middle_name":"C.L.M.","organization":"School of Basic Sciences, Institute of Physics, Laboratory of Biological Electron Microscopy, Swiss Federal Institute of Technology (EPFL)","street":"Rte de la Sorge","town_or_city":"Lausanne","state_or_province":"Vaud","post_or_zip":"1015","first_name":"Lukas","last_name":"van den Heuvel","country":"Switzerland"}},"authors":[{"author":{"name":"van den Heuvel L","author_orcid":"0000-0001-9168-8450"}},{"author":{"name":"Burger D","author_orcid":"0000-0002-4181-2588"}},{"author":{"name":"Kashyrina M","author_orcid":"0000-0001-7266-6387"}},{"author":{"name":"de La Seigliere H","author_orcid":"0009-0007-2828-5780"}},{"author":{"name":"Lewis AJ","author_orcid":"0000-0001-7257-5848"}},{"author":{"name":"De Nuccio F","author_orcid":"0000-0003-2041-0149"}},{"author":{"name":"Mohammed I","author_orcid":"0000-0001-8177-1349"}},{"author":{"name":"Verchere J","author_orcid":null}},{"author":{"name":"Feuillie C","author_orcid":"0000-0003-2222-8658"}},{"author":{"name":"Berbon M","author_orcid":"0000-0003-3235-253X"}},{"author":{"name":"Arotcarena M.","author_orcid":"0000-0002-1306-3700"}},{"author":{"name":"Retailleau A","author_orcid":"0000-0001-6367-1889"}},{"author":{"name":"Bezard E","author_orcid":"0000-0002-0410-4638"}},{"author":{"name":"Canron M","author_orcid":"0000-0003-1032-7632"}},{"author":{"name":"Meissner WG","author_orcid":"0000-0003-2172-7527"}},{"author":{"name":"Loquet A","author_orcid":"0000-0001-7176-7813"}},{"author":{"name":"Bousset L","author_orcid":"0000-0002-0433-4337"}},{"author":{"name":"Poujol C","author_orcid":"0000-0002-5222-9064"}},{"author":{"name":"Nilsson KPR","author_orcid":null}},{"author":{"name":"Laferriere F","author_orcid":"0000-0002-0753-5505"}},{"author":{"name":"Baron T","author_orcid":"0000-0001-5396-7707"}},{"author":{"name":"Lofrumento DD","author_orcid":"0000-0002-0106-3615"}},{"author":{"name":"De Giorgi F","author_orcid":"0000-0003-4850-3582"}},{"author":{"name":"Stahlberg H","author_orcid":"0000-0002-1185-4592"}},{"author":{"name":"Ichas 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GB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["9rzf"],"entry_doi":"10.6019/EMPIAR-12890"}}