{"EMPIAR-12808":{"imagesets":[{"segmentations":[],"name":"Extracted particle stacks of co-aggregates formed by human and rat IAPP (hIAPP and rIAPP) at varying ratios and in different buffer conditions.","directory":"data","category":"picked particles - multiframe - processed","header_format":"MRCS","data_format":"MRCS","num_images_or_tilt_series":1200,"frames_per_image":40,"frame_range_min":null,"frame_range_max":null,"voxel_type":"32 BIT FLOAT","pixel_width":null,"pixel_height":null,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"This dataset contains a randomized subset of RELION-extracted particle stacks of amyloid fibrils formed by co-aggregation of human and rat islet amyloid polypeptide (hIAPP and rIAPP) under various conditions. The dataset is organized into four top-level directories based on the aggregation buffer used, and each is further subdivided into four directories corresponding to different hIAPP:rIAPP ratios (1:0, 1:1, 1:4, and 1:20).","image_width":"4096","image_height":"4096"}],"workflow_file":null,"grant_references":[{"funding_body":"Swedish Research Council","code":"VR 2020-05403","country":"Sweden"}],"version_history":[],"title":"Cryo Electron Microscopy of hIAPP and rIAPP fibrils in different aggregation solutions","principal_investigator":[{"author_orcid":"0000-0003-1567-9514","middle_name":null,"organization":"Department of Chemistry - Angstrom, Uppsala University","street":null,"town_or_city":"Uppsala","state_or_province":null,"post_or_zip":"752 37","telephone":null,"fax":null,"first_name":"Michal","last_name":"Maj","email":"michal.maj [at] kemi.uu.se","country":"Sweden","entry":"EMPIAR-12808"}],"status":"REL","deposition_date":"2025-05-15","release_date":"2025-11-21","obsolete_date":null,"update_date":"2025-11-21","corresponding_author":{"author":{"author_orcid":"0000-0003-1567-9514","middle_name":null,"organization":"Department of Chemistry - Angstrom, Uppsala University","street":null,"town_or_city":"Uppsala","state_or_province":null,"post_or_zip":"752 37","first_name":"Michal","last_name":"Maj","country":"Sweden"}},"authors":[{"author":{"name":"Valli DV","author_orcid":"0009-0005-6060-4169"}},{"author":{"name":"Maj MM","author_orcid":"0000-0003-1567-9514"}}],"cross_references":[],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Valli DV","author_orcid":"0009-0005-6060-4169"},{"name":"Maj MM","author_orcid":"0000-0003-1567-9514"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Cryo-Electron Microscopy Provides Mechanistic Insights into Solution-Dependent Polymorphism and Cross-Aggregation Phenomena of the Human and Rat Islet Amyloid Polypeptides","volume":null,"country":"","first_page":null,"last_page":null,"year":"2025","language":"English","doi":"10.1021/acs.biochem.5c00042","pubmedid":null,"details":"Subsets of particles used for 2D classification of human and rat amyloid polypeptides fibrils in different conditions.\n100,000 particles from each dataset were randomly selected.","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Biochemistry","journal_abbreviation":"Biochemistry","issue":null,"preprint":false}],"dataset_size":"737.2 GB","experiment_type":"Exception","scale":"molecule","entry_doi":"10.6019/EMPIAR-12808"}}