{"EMPIAR-12410":{"imagesets":[{"segmentations":[],"name":"SC2A-HcA2-LEV","directory":"data/imageset_1","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":6518,"frames_per_image":48,"frame_range_min":1,"frame_range_max":48,"voxel_type":"UNSIGNED BYTE","pixel_width":0.83,"pixel_height":0.83,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"- 8JLC / EMD-36392\n- 8JLE / EMD-36394\n- 8JS8 / EMD-36616\n- 8JLH / EMD-36397\n\n- Microscope: FEI TITAN Krios\n- Detector: Gatan K3 BIOQUANTUM\n- Acceleration voltage (kV): 300\n- The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value.\n- Spherical aberration (Cs) : 2.7\n- Nominal Defocus (μm): 0.8 - 2.0\n- Average electron dose per image (e-/A2): 50.8\n- Please use 'gain.mrc' as a gain reference without rotation and y-flipping.","image_width":"5760","image_height":"4092"},{"segmentations":[],"name":"SV2-LEV","directory":"data/imageset_2","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":10001,"frames_per_image":48,"frame_range_min":1,"frame_range_max":48,"voxel_type":"UNSIGNED BYTE","pixel_width":0.83,"pixel_height":0.83,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"- 8JLI / EMD-36398\n\n- Microscope: FEI TITAN Krios\n- Detector: Gatan K3 BIOQUANTUM\n- Acceleration voltage (kV): 300\n- The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value.\n- Spherical aberration (Cs) : 2.7\n- Nominal Defocus (μm): 0.8 - 2.0\n- Average electron dose per image (e-/A2): 50.2\n- Please use 'gain.mrc' as a gain reference without rotation and y-flipping.","image_width":"5760","image_height":"4092"},{"segmentations":[],"name":"SV2A-HcA2","directory":"data/imageset_3","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":5930,"frames_per_image":48,"frame_range_min":1,"frame_range_max":48,"voxel_type":"UNSIGNED BYTE","pixel_width":0.83,"pixel_height":0.83,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"- 8JLF / EMD-36395\n- 8JLG / EMD-36396\n- 8JS9 / EMD-36617\n\n- Microscope: FEI TITAN Krios\n- Detector: Gatan K3 BIOQUANTUM\n- Acceleration voltage (kV): 300\n- The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value.\n- Spherical aberration (Cs) : 2.7\n- Nominal Defocus (μm): 0.8 - 2.0\n- Average electron dose per image (e-/A2): 50.0\n- Please use 'gain.mrc' as a gain reference without rotation and y-flipping.","image_width":"5760","image_height":"4092"},{"segmentations":[],"name":"SV2A-HcA2-BRV","directory":"data/imageset_4","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":6001,"frames_per_image":48,"frame_range_min":1,"frame_range_max":48,"voxel_type":"UNSIGNED BYTE","pixel_width":0.83,"pixel_height":0.83,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"- 8K77 / EMD-36933, EMD-36934, EMD-36935\n\n- Microscope: FEI TITAN Krios\n- Detector: Gatan K3 BIOQUANTUM\n- Acceleration voltage (kV): 300\n- The pixel size in the image header (1 Å/px) is wrong. 0.83 Å/px is the calibrated value.\n- Spherical aberration (Cs) : 2.7\n- Nominal Defocus (μm): 0.8 - 2.0\n- Average electron dose per image (e-/A2): 50.0\n- Please use 'gain.mrc' as a gain reference without rotation and y-flipping.","image_width":"5760","image_height":"4092"}],"workflow_file":null,"grant_references":[],"version_history":[],"title":"Cryo-EM structures of SV2A in complex with antiepileptic drugs and botulinum neurotoxin A2 receptor-binding domain","principal_investigator":[{"author_orcid":"0000-0001-9285-1256","middle_name":null,"organization":"RIKEN Center for Biosystems Dynamics Research","street":"1-7-22 Suehiro-cho","town_or_city":"Tsurumi-ku, Yokohama","state_or_province":"Kanagawa","post_or_zip":"230-0045","telephone":null,"fax":null,"first_name":"Atsushi","last_name":"Yamagata","email":"atsushi.yamagata [at] riken.jp","country":"Japan","entry":"EMPIAR-12410"}],"status":"REL","deposition_date":"2024-09-05","release_date":"2025-06-26","obsolete_date":null,"update_date":"2025-06-26","corresponding_author":{"author":{"author_orcid":"0000-0001-9285-1256","middle_name":null,"organization":"RIKEN Center for Biosystems Dynamics Research","street":"1-7-22 Suehiro-cho","town_or_city":"Tsurumi-ku, Yokohama","state_or_province":"Kanagawa","post_or_zip":"230-0045","first_name":"Atsushi","last_name":"Yamagata","country":"Japan"}},"authors":[{"author":{"name":"Yamagata A","author_orcid":"0000-0001-9285-1256"}},{"author":{"name":"Ito K","author_orcid":null}},{"author":{"name":"Suzuki T","author_orcid":"0000-0002-0585-6305"}},{"author":{"name":"Dohmae N","author_orcid":"0000-0002-5242-9410"}},{"author":{"name":"Terada T","author_orcid":"0000-0002-7091-0646"}},{"author":{"name":"Shirouzu M","author_orcid":"0000-0002-7997-2149"}}],"cross_references":["EMD-36934","EMD-36933","EMD-36617","EMD-36397","EMD-36616","EMD-36935","EMD-36398","EMD-36392","EMD-36396","EMD-36394"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Yamagata A","author_orcid":"0000-0001-9285-1256"},{"name":"Ito K","author_orcid":null},{"name":"Suzuki T","author_orcid":"0000-0002-0585-6305"},{"name":"Dohmae N","author_orcid":"0000-0002-5242-9410"},{"name":"Terada T","author_orcid":"0000-0002-7091-0646"},{"name":"Shirouzu M","author_orcid":"0000-0002-7997-2149"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A","volume":"15","country":"","first_page":null,"last_page":null,"year":"2024","language":"English","doi":"10.1038/s41467-024-47322-4","pubmedid":"38637505","details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Nature communications","journal_abbreviation":"Nat Commun","issue":"1","preprint":false}],"dataset_size":"6.6 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["8js9","8jlh","8js8","8k77","8jli","8jlc","8jlg","8jle"],"entry_doi":"10.6019/EMPIAR-12410"}}