{"EMPIAR-12317":{"imagesets":[{"segmentations":[],"name":"Aligned micrographs  of mouse alpha-synuclein","directory":"data","category":"micrographs - single frame","header_format":"MRC","data_format":"MRC","num_images_or_tilt_series":5358,"frames_per_image":1,"frame_range_min":null,"frame_range_max":null,"voxel_type":"16 BIT FLOAT","pixel_width":0.878,"pixel_height":0.878,"micrographs_file_pattern":"data/Micrographs","picked_particles_file_pattern":"data/ManualPick/manualpick.star","picked_particles_directory":"data/ManualPick/raw","details":"The data was collected using a Glacios 200 kV system equipped with a K3 camera.  A total of 5358 micrographs were motion-corrected, with a 180-degree rotation gain reference was applied, utilizing RELION's implementation of MotionCor2 for alignment. Coordinates for manually picked particles are available in the ManualPick folder.","image_width":"5760","image_height":"4092"},{"segmentations":[],"name":"Aligned micrographs  of mouse alpha-synuclein dataset 2","directory":"data","category":"micrographs - single frame","header_format":"MRC","data_format":"MRC","num_images_or_tilt_series":2579,"frames_per_image":1,"frame_range_min":null,"frame_range_max":null,"voxel_type":"32 BIT FLOAT","pixel_width":1.08,"pixel_height":1.08,"micrographs_file_pattern":"data/Micrographs_2","picked_particles_file_pattern":"data/ManualPick_2/job0??/manualpick.star","picked_particles_directory":"data/ManualPick_2","details":"The data was collected using a Titan Krios 300 kV system equipped with a K3 camera.  Movie frames were gain-corrected, aligned, and dose-weighed using Relion 4.0 software. A total of 2579 micrographs from 2 sessions of data collection are used in the reconstruction. Coordinates for manually picked particles are available in the ManualPick folder.","image_width":"5760","image_height":"4092"}],"workflow_file":null,"grant_references":[{"funding_body":"Swiss National Science Foundation","code":"310030188548","country":"Switzerland"},{"funding_body":"Michael J. Fox Foundation","code":"ASAP-020527","country":"United States"}],"version_history":[],"title":"Micrographs for mouse alpha synuclein","principal_investigator":[{"author_orcid":"0000-0002-1185-4592","middle_name":null,"organization":"EPFL","street":null,"town_or_city":"Lausanne","state_or_province":null,"post_or_zip":"1015","telephone":null,"fax":null,"first_name":"Henning","last_name":"Stahlberg","email":"henning.stahlberg [at] epfl.ch","country":"Switzerland","entry":"EMPIAR-12317"},{"author_orcid":"0000-0002-3034-4061","middle_name":null,"organization":"Duke University, Duke Center for Neurodegeneration Research, Department of Pharmacology and Cancer Biology","street":"3 Genome court","town_or_city":"Durham","state_or_province":"NC","post_or_zip":"27710","telephone":null,"fax":null,"first_name":"Andrew","last_name":"West","email":"andrew.west [at] duke.edu","country":"United States","entry":"EMPIAR-12317"},{"author_orcid":"0000-0002-7360-1523","middle_name":null,"organization":"Duke University, Department of Computer Science","street":null,"town_or_city":"Durham","state_or_province":"NC","post_or_zip":"27710","telephone":null,"fax":null,"first_name":"Alberto","last_name":"Bartesaghi","email":"alberto.bartesaghi [at] duke.edu","country":"United States","entry":"EMPIAR-12317"},{"author_orcid":"0000-0001-9159-1413","middle_name":null,"organization":"Department of Health and Human Services, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health","street":null,"town_or_city":"Durham","state_or_province":"NC","post_or_zip":"27709","telephone":null,"fax":null,"first_name":"Mario","last_name":"Borgnia","email":"mario.borgnia2 [at] nih.gov","country":"United States","entry":"EMPIAR-12317"}],"status":"REL","deposition_date":"2024-04-03","release_date":"2025-07-16","obsolete_date":null,"update_date":"2025-07-16","corresponding_author":{"author":{"author_orcid":"0000-0003-3632-6208","middle_name":null,"organization":"Department of Biochemistry, University of Zurich","street":null,"town_or_city":"Zurich","state_or_province":null,"post_or_zip":"8052","first_name":"Meltem","last_name":"TATLI","country":"Switzerland"}},"authors":[{"author":{"name":"Tatli M","author_orcid":"0000-0003-3632-6208"}},{"author":{"name":"Sokratian A","author_orcid":"0000-0001-6654-5773"}},{"author":{"name":"Zhou Y","author_orcid":"0000-0002-0489-3614"}}],"cross_references":["EMD-50023","EMD-42294"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Sokratian A","author_orcid":"0000-0001-6654-5773"},{"name":"Zhou Y","author_orcid":"0000-0002-0489-3614"},{"name":"Tatli M","author_orcid":"0000-0003-3632-6208"},{"name":"Burbidge KJ","author_orcid":null},{"name":"Xu E","author_orcid":"0000-0003-3463-0337"},{"name":"Viverette E","author_orcid":null},{"name":"Donzelli S","author_orcid":null},{"name":"Duda AM","author_orcid":"0000-0002-8116-4714"},{"name":"Yuan Y","author_orcid":null},{"name":"Li H","author_orcid":"0009-0004-1228-0721"},{"name":"Strader S","author_orcid":"0000-0003-4417-3707"},{"name":"Patel N","author_orcid":"0009-0004-3440-895X"},{"name":"Shiell L","author_orcid":null},{"name":"Malankhanova T","author_orcid":null},{"name":"Chen O","author_orcid":"0009-0002-0474-9257"},{"name":"Mazzulli JR","author_orcid":"0000-0002-7692-2381"},{"name":"Perera L","author_orcid":"0000-0003-0823-1631"},{"name":"Stahlberg H","author_orcid":"0000-0002-1185-4592"},{"name":"Borgnia M","author_orcid":"0000-0001-9159-1413"},{"name":"Bartesaghi A","author_orcid":"0000-0002-7360-1523"},{"name":"Lashuel HA","author_orcid":"0000-0001-7682-8320"},{"name":"West AB","author_orcid":"0000-0002-3034-4061"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases","volume":"10","country":"","first_page":null,"last_page":null,"year":"2024","language":"English","doi":"10.1126/sciadv.adq3539","pubmedid":"39485845","details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Science advances","journal_abbreviation":"Sci Adv","issue":"44","preprint":false}],"dataset_size":"467.9 GB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["9ewv","8uie"],"entry_doi":"10.6019/EMPIAR-12317"}}