{"EMPIAR-12199":{"imagesets":[{"segmentations":[],"name":"Raw movies, 5-HT3A + SMP100, one of two datasets","directory":"data/5HT3A_150uM_SMP100_08232021/Micrographs","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":5030,"frames_per_image":55,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":1.1,"pixel_height":1.1,"micrographs_file_pattern":"data/5HT3A_150uM_SMP100_08232021/Micrographs/FoilHole_23483095_Data_23483617_23483619_20210823_145547_fractions.tiff","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Raw movies of 5-HT3AR in complex with 3x molar excess SMP100. Collected on titan krios and k3 camera. 81,000x magnification, super-resolution (import with 0.55 angstrom pixel size, 2x bin in Motioncorr), around 1 electron dose per frame. Dataset 1 of 2.","image_width":"11520","image_height":"8184"},{"segmentations":[],"name":"Raw movies, 5-HT3A + SMP100, two of two datasets","directory":"data/5HT3A_smp100_05022022/smp100_05022022/Micrographs","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":5625,"frames_per_image":55,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":1.1,"pixel_height":1.1,"micrographs_file_pattern":"data/5HT3A_smp100_05022022/smp100_05022022/Micrographs/FoilHole_1494445_Data_1493017_1493019_20220502_150415_fractions.tiff","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Raw movies of 5-HT3AR in complex with 3x molar excess SMP100. Collected on titan krios and k3 camera. 81,000x magnification, super-resolution (import with 0.55 angstrom pixel size, 2x bin in Motioncorr), around 1 electron dose per frame. Dataset 2 of 2.","image_width":"11520","image_height":"8184"}],"workflow_file":null,"grant_references":[{"funding_body":"National Institutes of Health (NIH)","code":"R01GM131216","country":"United States"}],"version_history":[],"title":"Full-length mouse 5-HT3A receptor in complex with SMP100, pre-activated and open-like","principal_investigator":[{"author_orcid":null,"middle_name":null,"organization":"Case Western Reserve University, Department of Pharmacology","street":"10900 Euclid Ave","town_or_city":"Cleveland","state_or_province":"Ohio","post_or_zip":"44106","telephone":null,"fax":null,"first_name":"Sudha","last_name":"Chakrapani","email":"sxc584 [at] case.edu","country":"United States","entry":"EMPIAR-12199"}],"status":"REL","deposition_date":"2024-07-15","release_date":"2024-08-28","obsolete_date":null,"update_date":"2024-08-28","corresponding_author":{"author":{"author_orcid":"0000-0002-1832-747X","middle_name":"Christopher","organization":"Department of Physiology and Biophysics, Case Western Reserve University","street":"10900 Euclid Ave","town_or_city":"Cleveland","state_or_province":"Ohio","post_or_zip":"44106","first_name":"Kevin","last_name":"Felt","country":"United States"}},"authors":[{"author":{"name":"Felt KCF","author_orcid":"0000-0002-1832-747X"}},{"author":{"name":"Chakrapani SC","author_orcid":null}}],"cross_references":["EMD-29421","EMD-29410"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Felt K","author_orcid":"0000-0002-1832-747X"},{"name":"Stauffer M","author_orcid":"0000-0002-0595-2276"},{"name":"Salas-Estrada L","author_orcid":null},{"name":"Guzzo PR","author_orcid":"0009-0007-4773-8052"},{"name":"Xie D","author_orcid":null},{"name":"Huang J","author_orcid":null},{"name":"Filizola M","author_orcid":"0000-0002-4382-8276"},{"name":"Chakrapani S","author_orcid":"0000-0003-0722-2338"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Structural basis for partial agonism in 5-HT<sub>3A</sub> receptors","volume":"31","country":"United States","first_page":"598","last_page":"609","year":"2024","language":"English","doi":"10.1038/s41594-023-01140-2","pubmedid":"38177669","details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Nature structural & molecular biology","journal_abbreviation":"Nat Struct Mol Biol","issue":"4","preprint":false}],"dataset_size":"6.3 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["8fsp","8frx"],"entry_doi":"10.6019/EMPIAR-12199"}}