{"EMPIAR-12141":{"imagesets":[{"segmentations":[],"name":"Tilt series of micrographs (magnification 42k) from sarcomeres of human cardiac muscle in the relaxed condition","directory":"data","category":"tilt series","header_format":"MRC","data_format":"MRC","num_images_or_tilt_series":5,"frames_per_image":12,"frame_range_min":null,"frame_range_max":null,"voxel_type":"32 BIT FLOAT","pixel_width":2.118,"pixel_height":2.118,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"The tilt series in the data directory (not including the files in the subdirectory Mag64k) were taken under 42k magnification. The pixel size was calibrated to 2.118 A. The tilt series in the subdirectory Mag64k were taken under 64k magnification. The pixel size was calibrated to 1.346 A.","image_width":"4092","image_height":"5760"},{"segmentations":[],"name":"Tilt series of micrographs (magnification 64k) from sarcomeres of human cardiac muscle in the relaxed condition","directory":"data/Mag64k","category":"tilt series","header_format":"MRC","data_format":"MRC","num_images_or_tilt_series":4,"frames_per_image":11,"frame_range_min":null,"frame_range_max":null,"voxel_type":"32 BIT FLOAT","pixel_width":1.346,"pixel_height":1.346,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"The tilt series in the data directory (not including the files in the subdirectory Mag64k) were taken under 42k magnification. The pixel size was calibrated to 2.118 A. The tilt series in the subdirectory Mag64k were taken under 64k magnification. The pixel size was calibrated to 1.346 A.","image_width":"4092","image_height":"5760"}],"workflow_file":null,"grant_references":[{"funding_body":"National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)","code":"R35 GM139616","country":"United States"},{"funding_body":"National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS)","code":"R21 AR077802","country":"United States"},{"funding_body":"National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)","code":"HL 128683","country":"United States"},{"funding_body":"National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)","code":"HL 160966","country":"United States"},{"funding_body":"National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)","code":"R01 AI087846","country":"United States"},{"funding_body":"National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)","code":"R01 AI152421","country":"United States"}],"version_history":[],"title":"Structure of mavacamten-free human cardiac thick filaments within the sarcomere by cryoelectron tomography","principal_investigator":[{"author_orcid":"0000-0001-9594-8360","middle_name":null,"organization":"Department of Biological Science and Institute of Molecular Biophysics, Florida State University","street":"91 Chieftan Way","town_or_city":"Tallahassee","state_or_province":"Florida","post_or_zip":"32304","telephone":null,"fax":null,"first_name":"Kenneth","last_name":"Taylor","email":"ktaylor [at] fsu.edu","country":"United States","entry":"EMPIAR-12141"},{"author_orcid":"0000-0003-3108-6735","middle_name":null,"organization":"Microbial Sciences Institute, Department of Microbial Pathogenesis, Yale University School of Medicine","street":"840 West Campus Drive","town_or_city":"West Haven","state_or_province":"Connecticut","post_or_zip":"06516","telephone":null,"fax":null,"first_name":"Jun","last_name":"Liu","email":"jliu [at] yale.edu","country":"United States","entry":"EMPIAR-12141"},{"author_orcid":"0000-0002-9682-3014","middle_name":null,"organization":"Physiology & Cell Biology Department, Ohio State University","street":"1645 Neil Avenue","town_or_city":"Columbus","state_or_province":"Ohio","post_or_zip":"43210","telephone":null,"fax":null,"first_name":"Paul","last_name":"Janssen","email":"janssen.10 [at] osu.edu","country":"United States","entry":"EMPIAR-12141"},{"author_orcid":"0000-0001-9092-4976","middle_name":null,"organization":"College of Medicine, Florida State University","street":"1115 West Call Street","town_or_city":"Tallahassee","state_or_province":"Florida","post_or_zip":"32306","telephone":null,"fax":null,"first_name":"Jose","last_name":"Pinto","email":"jose.pinto [at] med.fsu.edu","country":"United States","entry":"EMPIAR-12141"}],"status":"REL","deposition_date":"2024-05-16","release_date":"2024-07-08","obsolete_date":null,"update_date":"2024-07-08","corresponding_author":{"author":{"author_orcid":"0000-0001-9594-8360","middle_name":null,"organization":"Department of Biological Science and Institute of Molecular Biophysics, Florida State University","street":"91 Chieftan Way","town_or_city":"Tallahassee","state_or_province":"Florida","post_or_zip":"32304","first_name":"Kenneth","last_name":"Taylor","country":"United States"}},"authors":[{"author":{"name":"Chen L","author_orcid":"0000-0002-1285-747X"}},{"author":{"name":"Liu J","author_orcid":"0000-0003-3108-6735"}},{"author":{"name":"Rastegarpouyani H","author_orcid":"0000-0003-1358-9910"}},{"author":{"name":"Janssen PML","author_orcid":"0000-0002-9682-3014"}},{"author":{"name":"Pinto JR","author_orcid":"0000-0001-9092-4976"}},{"author":{"name":"Taylor KA","author_orcid":"0000-0001-9594-8360"}}],"cross_references":["EMD-40471","EMD-40468","EMD-40475","EMD-40478","EMD-40476"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Chen L","author_orcid":"0000-0002-1285-747X"},{"name":"Liu J","author_orcid":"0000-0003-3108-6735"},{"name":"Rastegarpouyani H","author_orcid":"0000-0003-1358-9910"},{"name":"Janssen PML","author_orcid":"0000-0002-9682-3014"},{"name":"Pinto JR","author_orcid":"0000-0001-9092-4976"},{"name":"Taylor KA","author_orcid":"0000-0001-9594-8360"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Structure of mavacamten-free human cardiac thick filaments within the sarcomere by cryoelectron tomography","volume":"121","country":"United States","first_page":null,"last_page":null,"year":"2024","language":"English","doi":"10.1073/pnas.2311883121","pubmedid":"38386705","details":"The micrographs in the tilt series are drift corrected but not aligned as described in the paper.","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Proceedings of the National Academy of Sciences of the United States of America","journal_abbreviation":"Proc Natl Acad Sci U S A","issue":"9","preprint":false}],"dataset_size":"25.6 GB","experiment_type":"EMDB","scale":"molecule","entry_doi":"10.6019/EMPIAR-12141"}}