{"EMPIAR-12045":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame Tif movies of extracted amyloid fibrils from post-mortem human AD patient brain","directory":"data/Movies_tifs","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":10860,"frames_per_image":38,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":0.83,"pixel_height":0.83,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Movie stacks are gain corrected but unaligned, 10,860 movies, each containing 38 tiff frames with a dose per frame of ~1.15 e-/Å2. The total cumulative dose for each movie is ~44 e-/Å2 over a 4 s exposure. Predominantly Tau fibrils present, also meshes of abeta fibrils and a small percentage of fibrils that resemble TMEM106B from 2D class averages.","image_width":"4096","image_height":"4096"}],"workflow_file":null,"grant_references":[{"funding_body":"Wellcome Trust","code":"204963","country":"United Kingdom"},{"funding_body":"UK Research and Innovation (UKRI)","code":"MR/V022644/1","country":"United Kingdom"}],"version_history":[],"title":"CryoEM movies of human tau amyloid fibrils extracted from an AD patient brain (in association with in situ cryoET)","principal_investigator":[{"author_orcid":"0000-0001-9724-9547","middle_name":"AW","organization":"University of Leeds","street":"Woodhouse","town_or_city":"Leeds","state_or_province":null,"post_or_zip":"LS2 9JT","telephone":null,"fax":null,"first_name":"René","last_name":"Frank","email":"R.Frank [at] leeds.ac.uk","country":"United Kingdom","entry":"EMPIAR-12045"}],"status":"REL","deposition_date":"2024-04-15","release_date":"2024-09-03","obsolete_date":null,"update_date":"2024-09-03","corresponding_author":{"author":{"author_orcid":"0000-0001-9724-9547","middle_name":"AW","organization":"University of Leeds","street":"Woodhouse","town_or_city":"Leeds","state_or_province":"Yorkshire","post_or_zip":"LS2 9JT","first_name":"René","last_name":"Frank","country":"United Kingdom"}},"authors":[{"author":{"name":"Gilbert MAG","author_orcid":"0009-0007-3609-7499"}},{"author":{"name":"Fatima N","author_orcid":null}},{"author":{"name":"Jenkins J","author_orcid":null}},{"author":{"name":"O'Sullivan TJ","author_orcid":null}},{"author":{"name":"Schertel A","author_orcid":null}},{"author":{"name":"Halfon Y","author_orcid":null}},{"author":{"name":"Wilkinson M","author_orcid":"0000-0001-5490-613X"}},{"author":{"name":"Morrema THJ","author_orcid":null}},{"author":{"name":"Geibel M","author_orcid":"0000-0002-9697-6408"}},{"author":{"name":"Read RJ","author_orcid":"0000-0001-8273-0047"}},{"author":{"name":"Ranson NA","author_orcid":"0000-0002-3640-5275"}},{"author":{"name":"Radford SE","author_orcid":"0000-0002-3079-8039"}},{"author":{"name":"Hoozemans JJM","author_orcid":"0000-0002-2888-8967"}},{"author":{"name":"Frank RAW","author_orcid":"0000-0001-9724-9547"}}],"cross_references":["EMD-18990"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Gilbert MAG","author_orcid":"0009-0007-3609-7499"},{"name":"Fatima N","author_orcid":null},{"name":"Jenkins J","author_orcid":null},{"name":"O'Sullivan TJ","author_orcid":null},{"name":"Schertel A","author_orcid":null},{"name":"Halfon Y","author_orcid":null},{"name":"Wilkinson M","author_orcid":"0000-0001-5490-613X"},{"name":"Morrema THJ","author_orcid":null},{"name":"Geibel M","author_orcid":"0000-0002-9697-6408"},{"name":"Read RJ","author_orcid":"0000-0001-8273-0047"},{"name":"Ranson NA","author_orcid":"0000-0002-3640-5275"},{"name":"Radford SE","author_orcid":"0000-0002-3079-8039"},{"name":"Hoozemans JJM","author_orcid":"0000-0002-2888-8967"},{"name":"Frank RAW","author_orcid":"0000-0001-9724-9547"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"CryoET of β-amyloid and tau within postmortem Alzheimer's disease brain","volume":"631","country":"","first_page":"913","last_page":"919","year":"2024","language":"English","doi":"10.1038/s41586-024-07680-x","pubmedid":"38987603","details":"10,861 unaligned, gain corrected tif movies are supplied, each containing 38 frames with a dose per frame of ~1.15 e-/Å2. The pixel size is 0.83 Å, data collected on Krios-Falcon4.","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Nature","journal_abbreviation":"Nature","issue":"8022","preprint":false}],"dataset_size":"1.4 TB","experiment_type":"EMDB","scale":"molecule","entry_doi":"10.6019/EMPIAR-12045"}}