{"EMPIAR-11930":{"imagesets":[{"segmentations":[],"name":"Multi-frame micrographs of amyloid fibrils formed by the LCD of TFG with the P285L mutation","directory":"data","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":7921,"frames_per_image":40,"frame_range_min":null,"frame_range_max":null,"voxel_type":"UNSIGNED BYTE","pixel_width":null,"pixel_height":null,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"","image_width":"11520","image_height":"8184"}],"workflow_file":null,"grant_references":[{"funding_body":"National Institutes of Health/National Institute on Aging (NIH/NIA)","code":"R01AG048120","country":"United States"},{"funding_body":"National Institutes of Health/National Institute on Aging (NIH/NIA)","code":"R01AG07895","country":"United States"},{"funding_body":"National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)","code":"U24 GM129541","country":"United States"},{"funding_body":"National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)","code":"U24GM116792","country":"United States"},{"funding_body":"National Institutes of Health/Office of the Director","code":"1S10OD018111","country":"United States"},{"funding_body":"National Science Foundation (NSF, United States)","code":"DBI-1338135","country":"United States"},{"funding_body":"National Science Foundation (NSF, United States)","code":"DMR-1548924","country":"United States"}],"version_history":[],"title":"CryoEM of Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fibers","principal_investigator":[{"author_orcid":"0000-0003-2432-5419","middle_name":null,"organization":"Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA","street":"611 Charles E Young Dr E","town_or_city":"Los Angeles","state_or_province":"California","post_or_zip":"90095","telephone":null,"fax":null,"first_name":"David","last_name":"Eisenberg","email":"david [at] mbi.ucla.edu","country":"United States","entry":"EMPIAR-11930"}],"status":"REL","deposition_date":"2024-02-29","release_date":"2025-04-10","obsolete_date":null,"update_date":"2025-04-10","corresponding_author":{"author":{"author_orcid":"0000-0003-2432-5419","middle_name":null,"organization":"Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA","street":"611 Charles E Young Dr E","town_or_city":"Los Angeles","state_or_province":"California","post_or_zip":"90095","first_name":"David","last_name":"Eisenberg","country":"United States"}},"authors":[{"author":{"name":"Rosenberg GM","author_orcid":"0000-0002-1297-1715"}},{"author":{"name":"Abskharon R","author_orcid":"0000-0003-1350-0189"}},{"author":{"name":"Boyer DR","author_orcid":"0000-0002-4487-0230"}},{"author":{"name":"Ge P","author_orcid":null}},{"author":{"name":"Sawaya MR","author_orcid":"0000-0003-0874-9043"}},{"author":{"name":"Eisenberg DS","author_orcid":"0000-0003-2432-5419"}}],"cross_references":["EMD-41198"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Rosenberg GM","author_orcid":"0000-0002-1297-1715"},{"name":"Abskharon R","author_orcid":"0000-0003-1350-0189"},{"name":"Boyer DR","author_orcid":"0000-0002-4487-0230"},{"name":"Ge P","author_orcid":null},{"name":"Sawaya MR","author_orcid":"0000-0003-0874-9043"},{"name":"Eisenberg DS","author_orcid":"0000-0003-2432-5419"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method","volume":"2","country":"","first_page":null,"last_page":null,"year":"2023","language":"English","doi":"10.1093/pnasnexus/pgad402","pubmedid":"38077690","details":"The micrographs are the average of 40 raw movie frames (accumulating 50 electrons per square Angstrom in a 0.05 second exposure)","book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"PNAS nexus","journal_abbreviation":"PNAS Nexus","issue":"12","preprint":false}],"dataset_size":"3.5 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["8ter"],"entry_doi":"10.6019/EMPIAR-11930"}}