{"EMPIAR-11928":{"imagesets":[{"segmentations":[],"name":"K3 movies for site-one protease complexed to SPRING","directory":"data/20230629full","category":"micrographs - multiframe","header_format":"TIFF","data_format":"TIFF","num_images_or_tilt_series":4886,"frames_per_image":50,"frame_range_min":1,"frame_range_max":50,"voxel_type":"UNSIGNED BYTE","pixel_width":1.08,"pixel_height":1.08,"micrographs_file_pattern":"data/20230629full/Hailee*.tif","picked_particles_file_pattern":"","picked_particles_directory":"","details":"Unprocessed movies collected on Titan Krios G2 using bioquantum K3 operating in CDS mode. Superres pixel size is 0.54 A. Collected with a dose rate of 8 eps with a total dose of 48 e/A2. Nominal defocus range of -1 to -2 micron. Data are related to EMD-42639.","image_width":"5760","image_height":"4092"}],"workflow_file":null,"grant_references":[{"funding_body":"National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)","code":"R00GM141261","country":"United States"},{"funding_body":"Cancer Prevention and Research Institute of Texas (CPRIT)","code":"RP22052","country":"United States"}],"version_history":[],"title":"Cryo electron structure of the ectodomain of SPRING bound to the ectodomain of Site-one protease","principal_investigator":[{"author_orcid":"0000-0001-8657-9348","middle_name":null,"organization":"Department of Biochemistry, University of Texas Southwestern Medical Center","street":"5323 Harry Hines Blvd","town_or_city":"Dallas","state_or_province":"Texas","post_or_zip":"75390","telephone":null,"fax":null,"first_name":"Daniel","last_name":"Kober","email":"daniel.kober [at] utsouthwestern.edu","country":"United States","entry":"EMPIAR-11928"}],"status":"REL","deposition_date":"2023-11-07","release_date":"2025-03-17","obsolete_date":null,"update_date":"2025-03-17","corresponding_author":{"author":{"author_orcid":"0000-0001-8657-9348","middle_name":"L","organization":"University of Texas Southwestern Medical Center","street":"5323 Harry Hines Blvd","town_or_city":"Dallas","state_or_province":"TX","post_or_zip":"75390","first_name":"Daniel","last_name":"Kober","country":"United States"}},"authors":[{"author":{"name":"Kober DL","author_orcid":"0000-0001-8657-9348"}}],"cross_references":["EMD-42639"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Hendrix S","author_orcid":"0000-0003-2055-9883"},{"name":"Dartigue V","author_orcid":"0009-0009-5146-0596"},{"name":"Hall H","author_orcid":null},{"name":"Bawaria S","author_orcid":"0000-0002-0785-3044"},{"name":"Kingma J","author_orcid":"0000-0003-2822-5415"},{"name":"Bajaj B","author_orcid":null},{"name":"Zelcer N","author_orcid":"0000-0001-6935-7532"},{"name":"Kober DL","author_orcid":"0000-0001-8657-9348"}],"editors":[],"published":true,"j_or_nj_citation":true,"title":"SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain","volume":"15","country":"","first_page":null,"last_page":null,"year":"2024","language":"English","doi":"10.1038/s41467-024-50068-8","pubmedid":"38977690","details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Nature communications","journal_abbreviation":"Nat Commun","issue":"1","preprint":false}],"dataset_size":"2.9 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["8uw8"],"entry_doi":"10.6019/EMPIAR-11928"}}