{"EMPIAR-11884":{"imagesets":[{"segmentations":[],"name":"Unaligned multi-frame micrographs in the EER format of LEI-800-217bp DNA - Escherichia coli gyrase complex","directory":"data","category":"micrographs - multiframe","header_format":"EER","data_format":"EER","num_images_or_tilt_series":17017,"frames_per_image":639,"frame_range_min":null,"frame_range_max":null,"voxel_type":"BIT","pixel_width":0.68,"pixel_height":0.68,"micrographs_file_pattern":"","picked_particles_file_pattern":"","picked_particles_directory":"","details":"A dose per physical pixel of 8.8 e-/s was used, resulting in a total electron dose of 39.58 e-/Å2, fractionated across 639 EPU frames. Grouping into 49 frames will result in an electron dose of 0.8 e-/Å2 per frame.","image_width":"4096","image_height":"4096"}],"workflow_file":null,"grant_references":[],"version_history":[],"title":"E.coli DNA gyrase in complex with 217 bp substrate DNA and LEI-800","principal_investigator":[{"author_orcid":"0000-0001-9325-3207","middle_name":null,"organization":"John Innes Centre","street":null,"town_or_city":"Norwich","state_or_province":null,"post_or_zip":"NR4 7UH","telephone":null,"fax":null,"first_name":"Dmitry","last_name":"Ghilarov","email":"dmitry.ghilarov [at] jic.ac.uk","country":"United Kingdom","entry":"EMPIAR-11884"}],"status":"REL","deposition_date":"2024-02-01","release_date":"2024-06-27","obsolete_date":null,"update_date":"2024-06-27","corresponding_author":{"author":{"author_orcid":"0000-0001-9325-3207","middle_name":null,"organization":"John Innes Centre","street":"Colney Lane","town_or_city":"Norwich","state_or_province":"Norfolk","post_or_zip":"NR4 7UH","first_name":"Dmitry","last_name":"Ghilarov","country":"United Kingdom"}},"authors":[{"author":{"name":"Bakker A.T.","author_orcid":null}},{"author":{"name":"Kotsogianni I","author_orcid":null}},{"author":{"name":"Avalos M.","author_orcid":null}},{"author":{"name":"Punt J.M.","author_orcid":null}},{"author":{"name":"Liu B.","author_orcid":null}},{"author":{"name":"Piermarini D.","author_orcid":null}},{"author":{"name":"Gagestein B.","author_orcid":null}},{"author":{"name":"Slingerland C.J.","author_orcid":null}},{"author":{"name":"Zhang L.","author_orcid":null}},{"author":{"name":"Willemse J.J.","author_orcid":null}},{"author":{"name":"Ghimire L.B.","author_orcid":null}},{"author":{"name":"van den Berg R.J.H.B.N.","author_orcid":null}},{"author":{"name":"Janssen A.P.A.","author_orcid":null}},{"author":{"name":"Ottenhoff T.H.M.","author_orcid":null}},{"author":{"name":"van Boeckel C.A.A.","author_orcid":null}},{"author":{"name":"van Wezel G.P.","author_orcid":null}},{"author":{"name":"Ghilarov D.","author_orcid":null}},{"author":{"name":"Martin N.I.","author_orcid":null}},{"author":{"name":"van der Stelt M.","author_orcid":null}}],"cross_references":["EMD-18592"],"biostudies_references":[],"idr_references":[],"empiar_references":[],"citation":[{"authors":[{"name":"Bakker A.T.","author_orcid":null},{"name":"Kotsogianni I","author_orcid":null},{"name":"Avalos M.","author_orcid":null},{"name":"Punt J.M.","author_orcid":null},{"name":"Liu B.","author_orcid":null},{"name":"Piermarini D.","author_orcid":null},{"name":"Gagestein B.","author_orcid":null},{"name":"Slingerland C.J.","author_orcid":null},{"name":"Zhang L.","author_orcid":null},{"name":"Willemse J.J.","author_orcid":null},{"name":"Ghimire L.B.","author_orcid":null},{"name":"van den Berg R.J.H.B.N.","author_orcid":null},{"name":"Janssen A.P.A.","author_orcid":null},{"name":"Ottenhoff T.H.M.","author_orcid":null},{"name":"van Boeckel C.A.A.","author_orcid":null},{"name":"van Wezel G.P.","author_orcid":null},{"name":"Ghilarov D.","author_orcid":null},{"name":"Martin N.I.","author_orcid":null},{"name":"van der Stelt M.","author_orcid":null}],"editors":[],"published":false,"j_or_nj_citation":true,"title":"Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria","volume":null,"country":"United Kingdom","first_page":null,"last_page":null,"year":"2024","language":"English","doi":null,"pubmedid":null,"details":null,"book_chapter_title":null,"publisher":null,"publication_location":null,"journal":"Nature Chemistry","journal_abbreviation":"Nat. Chem.","issue":null,"preprint":false}],"dataset_size":"5.2 TB","experiment_type":"EMDB","scale":"molecule","related_pdb_entries":["8qqi"],"entry_doi":"10.6019/EMPIAR-11884"}}